Secretory carcinoma of the submandibular gland: A case report and literature review

doi:10.3877/cma.j.issn.1674-1366.2025.06.009

Abstract

Abstract:

Salivary secretory carcinoma (SSC) is a low-grade malignant tumor of the salivary gland, newly introduced in the fourth edition of the World Health Organization′s classification of head and neck tumors (2017). It is relatively rare in clinical practice, with very few reported cases involving the submandibular gland. This article reported one case of secretory carcinoma occurring in the submandibular gland and reviews related literature.

Key words: Salivary glands, Secretory carcinoma, Case report, Differential diagnosis

Weiwei Tang, Lijuan Xu, Jin Li, Lanlan Sheng. Secretory carcinoma of the submandibular gland: A case report and literature review[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(06): 405-409.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2025.06.009

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2025/V19/I06/405

Figures/Tables 3

References 22

[1]	Skálová A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands，containing the ETV6-NTRK3 fusion gene：A hitherto undescribed salivary gland tumor entity[J]. Am J Surg Pathol，2010，34(5)：599-608. DOI：10.1097/PAS.0b013e3181d9efcc.
[2]	Mete O, Wenig BM. Update from the 5th edition of the World Health Organization Classification of Head and Neck Tumors：Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms[J]. Head Neck Pathol，2022，16(1)：123-142. DOI：10.1007/s12105-022-01435-8.
[3]	Skálová A, Hyrcza MD, Leivo I. Update from the 5th edition of the World Health Organization Classification of Head and Neck Tumors：Salivary glands[J]. Head Neck Pathol，2022，16(1)：40-53. DOI：10.1007/s12105-022-01420-1.
[4]	Mehta R, Chakravarty S, Nagarkar NM, et al. Mammary analogue secretory carcinoma of submandibular gland[J]. Iran J Otorhinolaryngol，2022，34(122)：191-197. DOI：10.22038/IJORL.2022.59803.3062.
[5]	袁亚晨，赵立仙，潘云，等. 软腭唾液腺分泌性癌1例并文献复习[J]. 临床与病理杂志，2024，44(4)：628-635. DOI：10.11817/j.issn.2095-6959.2024.240135.
[6]	刘艳艳，汤晓飞，王凤光，等. 唾液腺分泌性癌10例临床病理分析[J]. 中华口腔医学杂志，2022，57(11)：1128-1133. DOI：10.3760/cma.j.cn112144-20220729-00415.
[7]	Asuquo J, Blavo C, Bhatta R. Secretory carcinoma of the philtrum of the upper lip：A case study [J]. Cureus，2024，16(9)：e68823. DOI：10.7759/cureus.68823.
[8]	Min FH, Li J, Tao BQ, et al. Parotid mammary analogue secretory carcinoma：A case report and review of literature[J]. World J Clin Cases，2021，9(16)：4052-4062. DOI：10.12998/wjcc.v9.i16.4052.
[9]	王松杰，赵军方. 涎腺分泌癌的临床表现及影像学特点[C]//中华口腔医学会口腔颌面-头颈肿瘤专业委员会. 2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会：创新超越、共赢未来论文汇编.武汉，2020：386. DOI：10.26914/c.cnkihy.2020.035024.
[10]	Black M, Liu CZ, Onozato M, et al. Concurrent identification of novel EGFR-SEPT14 fusion and ETV6-RET fusion in secretory carcinoma of the salivary gland[J]. Head Neck Pathol，2020，14(3)：817-821. DOI：10.1007/s12105-019-01074-6.
[11]	Kashiwagi N, Nakatsuka SI, Murakami T, et al. MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland：A preliminary report[J]. Dentomaxillofac Radiol，2018，47(5)：20170218. DOI：10.1259/dmfr.20170218.
[12]	Pang Y, Sun L, Liu H, Ma J. Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma[J]. Oral Oncol，2021，11(9)：105370. DOI：10.1016/j.oraloncology.2021.105370.
[13]	Wang T, Yang X, Yao L, et al. Clinicopathological analysis of 18 cases of secretory carcinoma of the salivary glands[J]. J Dent Sci，2024，19(1)：109-117. DOI：10.1016/j.jds.2023.05.023.
[14]	Fatima S, Ahmed A, Suleman S, et al. Utility of MUC4 in the diagnosis of secretory carcinoma of salivary glands[J]. Ann Diagn Pathol，2023，67：152220. DOI：10.1016/j.anndiagpath.2023.152220.
[15]	Katabi N. Oncocytoid salivary tumors：Differential diagnosis and utility of newly described immunohistochemistry[J]. Head Neck Pathol，2024，18(1)：20. DOI：10.1007/s12105-024-01622-9.
[16]	Peraza A, Gómez R, Beltran J, et al. Mucoepidermoid carcinoma. An update and review of the literature[J]. J Stomatol Oral Maxillofac Surg，2020，121(6)：713-720. DOI：10.1016/j.jormas.2020.06.003.
[17]	Wang F, Li B, Wang Y, et al. Clinical and pathological analysis of 10 cases of salivary gland epithelial-myoepithelial carcinoma[J]. Medicine （Baltimore），2020，99(41)：e22671. DOI：10.1097/MD.0000000000022671.
[18]	Pfister DG, Spencer S, Adelstein D, et al. Head and neck cancers，Version 2.2020，NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw，2020，18(7)：873-898. DOI：10.6004/jnccn.2020.0031.
[19]	Shukla S, Rathod PV, Pandya S, et al. Secretory carcinoma of salivary glands：A case series and review of literature[J]. Indian J Otolaryngol Head Neck Surg，2023，75(3)：2645-2649. DOI：10.1007/s12070-023-03560-4.
[20]	Baněčková M, Thompson LDR, Hyrcza MD, et al. Salivary gland secretory carcinoma：Clinicopathologic and genetic characteristics of 215 cases and proposal for a grading system[J]. Am J Surg Pathol，2023，47(6)：661-677. DOI：10.1097/PAS.0000000000002043.
[21]	Han F, Liu F, Wang H, et al. Clinicopathologic characterization of secretory carcinoma of salivary gland[J]. World J Surg Oncol，2024，22(1)：282. DOI：10.1186/s12957-024-03561-9.
[22]	Yosefof E, Boldes T, Dan D, et al. Salivary gland secretory carcinoma；Review of 13 years world-wide experience and Meta-analysis[J]. Laryngoscope，2024，134(4)：1716-1724. DOI：10.1002/lary.31123.

Please choose a citation manager

Content to export