Research progress on the regulatory role of m6A methylation modification of long non-coding RNA in various diseases

doi:10.3877/cma.j.issn.1674-1366.2022.01.001

Abstract

Abstract:

With the development of high-throughput sequencing technology, N⁶-methyladenosine (m⁶A) , as one of the most representative epigenetic modifications, widely exists on a variety of biological macromolecules and is fully involved in the regulation of various biological processes. As a regulator of life process, long non-coding RNA (lncRNA) participates in the regulation of various physiological processes and the development of diseases. Recently, m⁶A methylation modification was found on some lncRNAs, which affected the structure and function of lncRNA itself, and had different effects on a variety of diseases. Here, we reviewed the regulatory role of lncRNA m⁶A methylation in a variety of diseases, and made a prospect of its application in stomatology.

Key words: N⁶-methyladenosine (m⁶A), RNA methylation, Long non-coding RNA

Xin Chen, Jia Liu, Wen Qin, Zuolin Jin. Research progress on the regulatory role of m⁶A methylation modification of long non-coding RNA in various diseases[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(01): 1-6.

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