Research progress of Hippo signaling pathway in oral squamous cell carcinoma

doi:10.3877/cma.j.issn.1674-1366.2020.06.010

Abstract

Abstract:

Oral squamous cell carcinoma (OSCC) is one of the most common head and neck squamous cell carcinomas. At present, the surgery is mainly used, the chemoradiotherapy as a supplement, and a variety of treatment methods combined to comprehensive therapy for the treatment of OSCC. However, the 5-year survival rate of OSCC is still less than 50% owing to local recurrence and lymph node metastasis, and we still need to find more new therapies. The Hippo signaling pathway plays a crucial role in regulating organ size, cell number and homeostasis, as well as in the development of tumors. Recent studies have shown that the Hippo signaling pathway also plays an important role in regulating the proliferation, invasion and metastasis, apoptosis of OSCC, and maintaining the characteristics of OSCC tumor stem cells, therefore, the Hippo signaling pathway may provide a new target for the treatment of OSCC. This paper reviews the composition and regulatory mechanism of Hippo signaling pathway and the research progress of Hippo signaling pathway in OSCC, which may provide a broader horizon for the research and treatment of OSCC.

Key words: Carcinoma, squamous cell, Cell proliferation, Neoplasm metastasis, Hippo signaling pathway, Biological function

Chen Yi, Zixian Huang, Dongsheng Yu. Research progress of Hippo signaling pathway in oral squamous cell carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2020, 14(06): 396-400.

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