Abstract:
Objective To evaluate the etiology relationship between chronic periodontitis and stroke.
Methods Electronic search was conducted to find out the association between chronic periodontitis and stroke in CBM (1978—2016) , VIP chinese database, CNKI, Medline (OVID, 1950—2016) , EMBASE (1984—2016) and CENTRAL (2016, Issue 9) . Hand search was applied to the Chinese journals in oral research. Two investigators performed reference screening, quality evaluation and data collection (including incidence of periodontitis, CAL, PI and levels of CRP) . Revman 5.3.3 was applied for Meta-analysis of the data.
Results Twelve referen met the inclusion criteria (2 Chinese researches and 10 English researches) , including 2835 participants, 1396 of them with stroke. The result of Meta-analysis showed that the patients with stroke were more likely with chronic periodontitis[OR= 2.89, 95% CI= (2.00, 4.17) , P<0.001], more severe periodontitis[OR= 1.25, 95% CI= (0.50, 2.00) , P= 0.001] and poorer oral hygiene[OR= 0.32, 95% CI= (0.11, 0.54) , P= 0.004]. The levels of CRP increased obviously [OR= 5.38, 95% CI= (4.78, 5.97) , P<0.001].
Conclusion Chronic periodontitis and stroke have a possible correlation.
Key words:
Chronic periodontitis,
Stroke,
Evidence based medicine,
Meta analysis,
Etiology analysis
Zongkai Lyu, Yangcan Zheng, Shengnan Du, Yingyang Yang, Hui Feng, Lihui Deng. Relationship between chronic periodontitis and stroke: a Meta analysis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2017, 11(01): 31-35.