Correlation between Enterococcus faecalis and refractory periapical periodontitis：A Meta Analysis

doi:10.3877/cma.j.issn.1674-1366.2014.04.002

Abstract

Abstract:

Objective

To evaluate the correlation between Enterococcus faecalis and refractory periapical periodontitis.

Methods

Databases including PubMed， ScienceDirect， EMbase， WanFang Data， CNKI and VIP were searched from inception to December， 2013， so as to identify the independent cohort studies， case-control studies and cross-sectional studies. Moreover， the references of relevant studies were retrieved. According to the inclusion and exclusion criteria， the studies were screened， the data was extracted， and the methodological quality of the included studies was assessed. Then Metaanalysis was performed by Stata 12.0 software.

Results

A total of 18 studies were included， including 728 rafractory periapical periodontitis cases and 748 controlled cases. The results of Meta-analysis showed that the refractory periapical periodontitis group was more likely to have Enterococcus faecalis infection than the control group ［OR=3.559， 95% CI（1.696，7.470），P ＜0.05］. The same results were found in both sub-group and sensitivity analysis.

Conclusions

Enterococcus faecalis is closely related to refractory periapical periodontitis. However， detailed pathogenesis mechanism is still unknown. Due to the limited quality and quantity of the included studies， more high-quality studies are required to prove the analysis results above.

Key words: Enterococcus faecalis, Refractory periapical periodontitis, Correlation, Metaanalysis

Jianrong Du, Chenjiao Zhang, Zhixiang Peng. Correlation between Enterococcus faecalis and refractory periapical periodontitis：A Meta Analysis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2014, 8(04): 274-280.

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Figures/Tables 6

References 29

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纳入研究	研究地区	对照选择	检测方法	难治性根尖周炎组		对照组		NOS评分
纳入研究	研究地区	对照选择	检测方法	n	N	n	N	NOS评分
Molander^［16］ 1998	瑞典	初次根管治疗	培养	32	100	1	20	7
Gomes^［17］ 2004	巴西	初次根管治疗	培养	6	19	2	41	6
Rôças^［8］ 2004	巴西	初次根管治疗	PCR	20	30	9	50	8
Foschi^［18］ 2005	意大利	初次根管治疗	PCR	13	18	2	44	7
Kaufman^［19］ 2005	美国	其它原因的二次根管治疗	PCR	2	36	5	22	9
Gomes^［20］ 2006	巴西	初次根管治疗	培养	21	50	2	50	7
Gomes^［20］ 2006	巴西	初次根管治疗	PCR	38	50	41	50	7
Williams^［21］ 2006	美国	初次根管治疗	培养	2	14	1	15	8
Williams^［21］ 2006	美国	初次根管治疗	PCR	10	14	6	15	8
Zoletti^［22］ 2006	巴西	其它原因的二次根管治疗	培养	3	23	5	27	6
Zoletti^［22］ 2006	巴西	其它原因的二次根管治疗	PCR	18	23	22	27	6
Sedgley^［23］ 2006	瑞典	初次根管治疗	培养	4	48	5	40	8
Sedgley^［23］ 2006	瑞典	初次根管治疗	PCR	43	48	27	40	8
Pirani^［24］ 2008	意大利	初次根管治疗	PCR	9	23	6	79	7
Ozbek^［25］ 2009	土耳其	初次根管治疗	PCR	32	43	9	36	9
郭惠杰^［26］ 2011	中国	初次根管治疗	培养	32	45	1	45	8
Dumani^［27］ 2012	土耳其	初次根管治疗	PCR	11	114	19	117	7
龚闽^［28］ 2012	中国	初次根管治疗	PCR	16	30	3	30	6

纳入研究	研究地区	对照选择	检测方法	难治性根尖周炎组		对照组		NOS评分
纳入研究	研究地区	对照选择	检测方法	n	N	n	N	NOS评分
Molander^［16］ 1998	瑞典	初次根管治疗	培养	32	100	1	20	7
Gomes^［17］ 2004	巴西	初次根管治疗	培养	6	19	2	41	6
Rôças^［8］ 2004	巴西	初次根管治疗	PCR	20	30	9	50	8
Foschi^［18］ 2005	意大利	初次根管治疗	PCR	13	18	2	44	7
Kaufman^［19］ 2005	美国	其它原因的二次根管治疗	PCR	2	36	5	22	9
Gomes^［20］ 2006	巴西	初次根管治疗	培养	21	50	2	50	7
Gomes^［20］ 2006	巴西	初次根管治疗	PCR	38	50	41	50	7
Williams^［21］ 2006	美国	初次根管治疗	培养	2	14	1	15	8
Williams^［21］ 2006	美国	初次根管治疗	PCR	10	14	6	15	8
Zoletti^［22］ 2006	巴西	其它原因的二次根管治疗	培养	3	23	5	27	6
Zoletti^［22］ 2006	巴西	其它原因的二次根管治疗	PCR	18	23	22	27	6
Sedgley^［23］ 2006	瑞典	初次根管治疗	培养	4	48	5	40	8
Sedgley^［23］ 2006	瑞典	初次根管治疗	PCR	43	48	27	40	8
Pirani^［24］ 2008	意大利	初次根管治疗	PCR	9	23	6	79	7
Ozbek^［25］ 2009	土耳其	初次根管治疗	PCR	32	43	9	36	9
郭惠杰^［26］ 2011	中国	初次根管治疗	培养	32	45	1	45	8
Dumani^［27］ 2012	土耳其	初次根管治疗	PCR	11	114	19	117	7
龚闽^［28］ 2012	中国	初次根管治疗	PCR	16	30	3	30	6

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