The expression and significance of Ezrin Protein and iNOS in MEC

doi:10.3877 / cma.j.issn.1674-1366.2009-04-005

Abstract

Abstract:

Objective

To study the expression of Ezrin and inducible nitric oxide synthase（iNOS） in mucoepidermoid carcinoma （MEC） and the relationship between the positive rate of Ezrin， iNOS and MEC metastasis.

Methods

The expression of Ezrin， iNOS was detected by immunohistochemistry in 36 well-differentiated MEC cases， 24 poorly-differentiated MEC casese and 60 normal tissues.

Results

The expression of Ezrin and iNOS in normal tissues， welldifferentiated MEC tissues and poorly-differentiated MEC tissues were gradually increased （P ＜0.05）. There was significant positive correlation between Expression of Ezrin and iNOS（P ＜0.01）.Besides， positive correlation was also found between the expression of Ezrin and MEC metastasis（P ＜0.05） and between iNOS and MEC metastasis （P ＜0.05）.

Conclusions

There is relationship between Ezrin and iNOS， and they were all related to MEC metastasis.

Key words: Mucoepidermoid carcinoma, Ezrin, Inducible nitric oxide synthase

Lan YANG, Zhi-quan HUANG, Jun LIANG, Yun-hua YOU, Yong-yuan WANG, Ke-xiong OUYANG. The expression and significance of Ezrin Protein and iNOS in MEC[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2009, 3(04): 376-381.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877 / cma.j.issn.1674-1366.2009-04-005

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2009/V3/I04/376

Figures/Tables 11

References 20

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组别	例数	Ezrin表达			阳性率（%）	χ ²	P
组别	例数	-	+	++	阳性率（%）	χ ²	P
高分化MEC	36	12	10	14	66.67
低分化MEC	24	3	6	15	87.50	8.35	＜0.05
正常腺组织	60	38	20	2	36.67

组别	例数	Ezrin表达			阳性率（%）	χ ²	P
组别	例数	-	+	++	阳性率（%）	χ ²	P
高分化MEC	36	12	10	14	66.67
低分化MEC	24	3	6	15	87.50	8.35	＜0.05
正常腺组织	60	38	20	2	36.67

组别	例数	iNOS表达			阳性率（%）	χ ²	P
组别	例数	-	+	++	阳性率（%）	χ ²	P
高分化MEC	36	15	7	14	58.33
低分化MEC	24	5	7	12	79.17	7.94	＜0.05
正常腺组织	60	48	11	1	20.00

组别	例数	iNOS表达			阳性率（%）	χ ²	P
组别	例数	-	+	++	阳性率（%）	χ ²	P
高分化MEC	36	15	7	14	58.33
低分化MEC	24	5	7	12	79.17	7.94	＜0.05
正常腺组织	60	48	11	1	20.00

Ezrin表达	iNOS表达		合计	χ ²	P
Ezrin表达	-	+	合计	χ ²	P
-	43	10	53
+	25	42	67	21.39	＜0.001
合计	68	52	120

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