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Chinese Journal of Stomatological Research(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (05): 315-321. doi: 10.3877/cma.j.issn.1674-1366.2023.05.001

Special Issue:

• Expert Opinion •     Next Articles

Characteristics and significance of tertiary lymphoid structures in oral cancer

Chenxi Li, Xiaorong Tan, Wei Wei, Muqiu Li, Zhongcheng Gong()   

  1. Oncological Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology Xinjiang Medical University, Urumqi 830054, China; Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi 830054, China; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Oncological Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology Xinjiang Medical University, Urumqi 830054, China; Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi 830054, China
  • Received:2023-05-01 Online:2023-10-01 Published:2023-10-07
  • Contact: Zhongcheng Gong
  • Supported by:
    National Natural Science Foundation of China(82360481); Open Project of Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration(2022kqhm008); Xinjiang Postgraduate Scientific Research Innovation Project(XJ2023G174)

Abstract:

Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological conditions but arise in the context of chronic inflammation, such as autoimmune diseases, chronic infection, and cancer. In the setting of cancer development, TLSs facilitate the influx of immune cells into the cancer site and have therefore attracted interest as a means of improving anticancer immunity and favorable treatment response in patients. In spite of their presumed importance, the drivers of TLSs formation in cancer and the contribution of these structures to intratumoral immune response remain incompletely understood. In this article, the biology of TLSs and their recent advances in oral cancer research were reviewed.

Key words: Tumor microenvironment, Mouth neoplasms, Carcinoma, squamous cell, Immunotherapy, Cancer immunology

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