The role of dendritic cells in the pathogenesis of oral lichen planus

doi:10.3877/cma.j.issn.1674-1366.2022.04.005

Abstract

Abstract:

Dendritic cells (DCs) are the most powerful professional antigen-presenting cells (APCs) in the body. They can efficiently absorb, process and present antigens. Immature DCs have strong migration ability. Mature DCs can effectively activate initial T cells and are in the central link of initiating, regulating and maintaining immune response. Oral lichen planus (OLP) is a common chronic inflammatory disease of oral mucosa. The dense band infiltration of a large number of T lymphocytes in lamina propria is one of its typical pathological manifestations, indicating that OLP is related to T lymphocyte mediated immune response. However, the role of immune pathogenesis in the pathogenesis of oral lichen planus has been an unsolved research hotspot. Therefore, this review aims to summarize the role of dendritic cells in the pathogenesis of OLP.

Key words: Lichen planus, oral, Dendritic cells, Langerhans cells, Pathogenesis

Qian Xiao, Dandan Zhang, Ting Zhang, Chanjuan He, Weifang Zhang, Dengxun Wu, Ying Liu. The role of dendritic cells in the pathogenesis of oral lichen planus[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(04): 229-233.

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References 42

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亚型		标志物	表达该标志物的其他细胞类型
cDC
	cDC1	CD141	单核/巨噬细胞、粒细胞、内皮细胞和上皮细胞
	cDC2	CD11c	T细胞、B细胞、树突状细胞、NK细胞、单核/巨噬细胞
pDC		CD123	粒细胞和内皮细胞
LC		CD207	真皮树突状细胞
		CD1a	T细胞、B细胞、巨噬细胞
		S-100	单核细胞、巨噬细胞、淋巴细胞、黑色素细胞等

亚型		标志物	表达该标志物的其他细胞类型
cDC
	cDC1	CD141	单核/巨噬细胞、粒细胞、内皮细胞和上皮细胞
	cDC2	CD11c	T细胞、B细胞、树突状细胞、NK细胞、单核/巨噬细胞
pDC		CD123	粒细胞和内皮细胞
LC		CD207	真皮树突状细胞
		CD1a	T细胞、B细胞、巨噬细胞
		S-100	单核细胞、巨噬细胞、淋巴细胞、黑色素细胞等

研究	样本量及取材部位	标志物	结论
Kumar等^[16]	正常口腔黏膜=5	CD1a	OLP组CD1α⁺ LC数量无论在上皮内或上皮下均多于正常对照组（P=0.018）
	OLP=20		OLP组CD1α⁺ LC数量无论在上皮内或上皮下均多于正常对照组（P=0.018）
Souto等^[17]	正常口腔黏膜=7（第三磨牙颊黏膜）	CD1a	上皮内CD1a⁺ DC与正常黏膜差异无统计学意义，而固有层淋巴细胞浸润带与浸润带下区域CD1a⁺ DC多于正常对照组（P<0.05）
	OLP=7（颊黏膜）
Devi等^[18]	正常口腔黏膜=7（第三磨牙颊黏膜）	CD1a	OLP组CD1α⁺ LC数量多于正常对照组（P<0.001）
	OLP=11
Solhaug等^[15]	正常口腔黏膜=30	CD1a	OLP组CD1α⁺ LC数量多于正常对照组（P<0.05）
	OLP=30	Langerin/CD207
Maloth等^[19]	正常口腔黏膜=10（颊黏膜）	S100	OLP组LC数量多于正常对照组（P=0.001）
	OLP=17
Mukae等^[20]	正常口腔黏膜=30（颊、牙龈、舌）	CD1a	OLP组LC数量少于正常对照组（P<0.05）
	OLP=30	Langerin/CD207
		S-100
Wang等^[21]	正常口腔黏膜=9	CD1a	差异无统计学意义
	OLP=24	Langerin/CD207

研究	样本量及取材部位	标志物	结论
Kumar等^[16]	正常口腔黏膜=5	CD1a	OLP组CD1α⁺ LC数量无论在上皮内或上皮下均多于正常对照组（P=0.018）
	OLP=20		OLP组CD1α⁺ LC数量无论在上皮内或上皮下均多于正常对照组（P=0.018）
Souto等^[17]	正常口腔黏膜=7（第三磨牙颊黏膜）	CD1a	上皮内CD1a⁺ DC与正常黏膜差异无统计学意义，而固有层淋巴细胞浸润带与浸润带下区域CD1a⁺ DC多于正常对照组（P<0.05）
	OLP=7（颊黏膜）
Devi等^[18]	正常口腔黏膜=7（第三磨牙颊黏膜）	CD1a	OLP组CD1α⁺ LC数量多于正常对照组（P<0.001）
	OLP=11
Solhaug等^[15]	正常口腔黏膜=30	CD1a	OLP组CD1α⁺ LC数量多于正常对照组（P<0.05）
	OLP=30	Langerin/CD207
Maloth等^[19]	正常口腔黏膜=10（颊黏膜）	S100	OLP组LC数量多于正常对照组（P=0.001）
	OLP=17
Mukae等^[20]	正常口腔黏膜=30（颊、牙龈、舌）	CD1a	OLP组LC数量少于正常对照组（P<0.05）
	OLP=30	Langerin/CD207
		S-100
Wang等^[21]	正常口腔黏膜=9	CD1a	差异无统计学意义
	OLP=24	Langerin/CD207

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