Research progress of ferroptosis and its research prospects in tumor radiotherapy

doi:10.3877/cma.j.issn.1674-1366.2021.06.001

Abstract

Abstract:

Radioresistance and radiation damage are the difficult problem that need to be solved urgently in cancer radiotherapy. Ferroptosis is a novel type of cell death induced by iron overload and lipid peroxidation metabolic imbalance caused by the enhancement of intracellular reactive oxygen species (ROS) . ROS induced by ferroptosis can not only lead to cellular damage directly, but also improve the hypoxic microenvironment of tumors and sensitize radiotherapy. Ferroptosis plays an important role in inhibiting tumor proliferation and enhancing radiosensitivity, providing a potential new strategy for improving efficacy of radiotherapy. Here, we reviewed the research progress of ferroptosis and made a prospect of its application in radiotherapy.

Key words: Ferroptosis, Radiotherapy, Radiation damage, Neoplasms

Hongyu Li, Yanting Liu, Dongsheng Yu. Research progress of ferroptosis and its research prospects in tumor radiotherapy[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(06): 325-332.

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