Diode laser treatment for recurrent aphthous ulcer: A Meta analysis

doi:10.3877/cma.j.issn.1674-1366.2019.01.005

Abstract

Abstract:

Objective

To assess the effect and safety of diode laser treatment for recurrent aphthous ulcer.

Methods

The electronic search was conducted in CBM, CNKI, Medline, CENTRAL, EMBASE and PubMed database (from the date of buiding the database to July, 2018) . Clinical randomized controlled trials were selected which involved the targeted issue. Investigators screened out the included trials whose data were then collected and Revman 5.3.3 was applied for Meta-analysis.

Results

Eleven trials met the inclusion criteria and 877 patients were enrolled in the trials. Meta analysis showed a significantly decreased Visual Analogue Score VAS (WMD= 2.76, Z= 3.91, P<0.001) after treatment, with higher clinical efficiency (OR= 4.97, Z= 7.99, P<0.001) and shorter healing time of ulcer (WMD= -2.44, Z= 4.14, P<0.001) .

Conclusion

The evidence indicated that diode laser treatment played a positive role in remitting the clinical signs of recurrent aphthous ulcer and shortening the healing duration.

Key words: Lasers, semiconductor, Stomatitis, aphthous, Systematic Review, Meta-analysis

Zongkai Lyu, Yangcan Zheng, Shengnan Du, Hui Feng, Yingyang Yang, Lihui Deng. Diode laser treatment for recurrent aphthous ulcer: A Meta analysis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2019, 13(01): 23-27.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2019.01.005

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2019/V13/I01/23

Figures/Tables 5

References 19

[1]	Edgar NR, Saleh D, Miller RA. Recurrent Aphthous Stomatitis：A Review[J]. J Clin Aesthet Dermatol，2017，10(3):26-36.
[2]	Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects：literature review[J]. Arch Immunol Ther Exp（Warsz），2014，62(3):205-215. DOI：10.1007/s0005-013-0261-y.
[3]	Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review [J]. J Clin Exp Dent，2014，6(2):e168-e174. DOI：10.4317/jced.51401.
[4]	Prasad RS, Pai A. Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol，2013，116(2):189-193. DOI：10.1016/j.oooo.2013.02.011.
[5]	Aggarwal H, Singh MP, Nahar P，et al. Efficacy of low-level laser therapy in treatment of recurrent aphthous ulcers - a sham controlled，split mouth follow up study[J]. J Clin Diagn Res，2014，8(2):218-221. DOI：10.7860/JCDR/2014/7639.4064.
[6]	Albrektson M, Hedström L, Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy：a randomized controlled trial[J]. Oral Surg Oral Med Oral Pathol Oral Radiol，2014，117(5):590-594. DOI：10.1016/j.oooo.2014.01.228.
[7]	Lalabonova H, Daskalov H. Clinical assessment of the therapeutic effect of low-level laser therapy on chronic recurrent aphthous stomatitis[J]. Biotechnol Biotechnol Equip，2014，28(5):929-933. DOI：10.1080/13102818.2014.966526.
[8]	Hazeem MI, Rajab M, Badeia RA. Treatment of Recurrent Aphthous Stomatitis with 940nm Diode Laser[J]. Tikrit Journal for Dental Science，2013，1(1):77-82.
[9]	Salman H, Kashmoola MA, Al-Waiz MM，et al. Differences between low level laser therapy and triamcinolone acetonide kenalog on healing of recurrent aphthous ulceration[J]. Annals of the College of Medicine，2008，34(1):35-41.
[10]	De Souza TO, Martins MA, Bussadori SK，et al. Clinical evaluation of low-level laser treatment for recurring aphthous stomatitis[J]. Photomed Laser Surg，2010，28(Suppl 2):S85-S88. DOI：10.1089/pho.2009.2661.
[11]	彭川洋，张英，姜艾佳.半导体激光与重组人表皮生长因子凝胶治疗复发性阿弗他溃疡临床疗效对比研究[J].中国实用口腔科杂志，2016，9(9):538-541. DOI：10.7504/kq.2016.09.007.
[12]	曾娟，范媛.半导体激光治疗轻型复发性阿弗他溃疡的短期疗效观察[J].口腔医学，2011，31(6):349-351.
[13]	王婷，林松杉，刘奕，等.半导体激光治疗复发性阿弗他溃疡的临床观察[J].重庆医学，2017，46(24):3417-3420. DOI：10.3969/j.issn.1671-8348.2017.24.034.
[14]	蔡向平，徐东文.半导体激光治疗复发性阿弗他溃疡的临床观察[J].河南医学高等专科学校学报，2002，14(4):348-349. DOI：10.3969/j.issn.1008-9276.2002.04.036.
[15]	马缨卫，董莉莉，刘同军，等. 660 nm激光口腔治疗仪对阿弗他溃疡的疗效评价[J].山东大学学报（医学版），2010，48(12):75-77.
[16]	Moher D, Jones A, Lepage L，et al. Use of the CONSORT Statement and Quality of Reports of Randomized Trials-a comparative Before-and-After evaluation[J]. JAMA，2001，285(15):1992-1995. DOI：10.1001/jama.285.15.1992.
[17]	de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy[J]. IEEE J Sel Top Quantum Electron，2016，22(3):348-364. DOI：10.1109/JSTQE.2016.2561201.
[18]	Wagner VP, Meurer L, Martins MA，et al. Influence of different energy densities of laser phototherapy on oral wound healing[J]. J Biomed Opt，2013，18(12):128002. DOI：10.1117/1.JBO.18.12.128002.
[19]	Hamblin M, Demidova TN. Mechanisms of low level light therapy [J]. Proceedings of SPIE - The International Society for Optical Engineering，2006，6140(6):1-12. DOI：10.1117/12.646294.

纳入文献	患者人数		病程时间（d）		干预措施		CONSORT评分（总分22分）	JADAD评分（总分7分）
纳入文献	试验组	对照组	试验组	对照组	试验组二极管激光波长（nm）	对照组	CONSORT评分（总分22分）	JADAD评分（总分7分）
Aggarwal等^[5]	30	30	3.05 ± 1.10	8.90 ± 2.45	810	空白	13	3
Albrektson等^[6]	20	20	未报道	未报道	809	空白	16	5
Lalabonov等^[7]	90	90	未报道	未报道	658	格拉福林凝胶	13	3
Hazeem^[8]	32	32	6.66 ± 1.96	10.28 ± 2.08	940	空白	14	3
Salman等^[9]	21	12	3.38 ± 2.60	6.67 ± 6.10	904	空白	13	3
De Souza等^[10]	15	5	5.87 ± 1.36	6.80 ± 2.05	670	曲安奈德	14	4
彭川洋等^[11]	30	30	3.70 ± 0.79	4.93 ± 0.98	810	表皮生长因子	13	3
曾娟等^[12]	30	30	6.17 ± 0.33	6.67 ± 0.32	980	西瓜霜喷剂	12	3
王婷等^[13]	30	30	4.60 ± 1.98	7.34 ± 2.68	810	氯己定含漱液	14	4
蔡向平等^[14]	99	80	未报道	未报道	未报道	局涂药物（抗生素及止痛药）	11	3
马缨卫等^[15]	61	60	3.92 ± 1.17	6.45 ± 2.16	660	金达甘油	12	3

纳入文献	患者人数		病程时间（d）		干预措施		CONSORT评分（总分22分）	JADAD评分（总分7分）
纳入文献	试验组	对照组	试验组	对照组	试验组二极管激光波长（nm）	对照组	CONSORT评分（总分22分）	JADAD评分（总分7分）
Aggarwal等^[5]	30	30	3.05 ± 1.10	8.90 ± 2.45	810	空白	13	3
Albrektson等^[6]	20	20	未报道	未报道	809	空白	16	5
Lalabonov等^[7]	90	90	未报道	未报道	658	格拉福林凝胶	13	3
Hazeem^[8]	32	32	6.66 ± 1.96	10.28 ± 2.08	940	空白	14	3
Salman等^[9]	21	12	3.38 ± 2.60	6.67 ± 6.10	904	空白	13	3
De Souza等^[10]	15	5	5.87 ± 1.36	6.80 ± 2.05	670	曲安奈德	14	4
彭川洋等^[11]	30	30	3.70 ± 0.79	4.93 ± 0.98	810	表皮生长因子	13	3
曾娟等^[12]	30	30	6.17 ± 0.33	6.67 ± 0.32	980	西瓜霜喷剂	12	3
王婷等^[13]	30	30	4.60 ± 1.98	7.34 ± 2.68	810	氯己定含漱液	14	4
蔡向平等^[14]	99	80	未报道	未报道	未报道	局涂药物（抗生素及止痛药）	11	3
马缨卫等^[15]	61	60	3.92 ± 1.17	6.45 ± 2.16	660	金达甘油	12	3

Please choose a citation manager

Content to export