Role of miR-221/222 in tumor and their research progress in oral squamous cell carcinoma

doi:10.3877/cma.j.issn.1674-1366.2016.05.011

Abstract

Abstract:

MiR-221 and miR-222 (miR-221/222) are microRNAs, located on the X chromosome and have the same seed sequence. Studies have shown that miR-221/222 function as oncogenes or suppressor genes in lots of advanced cancers. MiR-221/222 play an important role in tumor development, such as signal activation, cell proliferation, differentiation, apoptosis, angiogenesis, invasion, migration and other biological processes. This article reviews the role of miR-221/222 in tumor development and their research progress in oral squamous cell carcinoma.

Key words: MicroRNA-221/222, Tumor, Oncogene, Carcinoma, squamous cell

Lijie Zhou, Dongsheng Yu. Role of miR-221/222 in tumor and their research progress in oral squamous cell carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2016, 10(05): 356-359.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2016.05.011

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2016/V10/I05/356

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