The progress on the biodegradation of resin-dentin adhesive interface mediated by the matrix metalloproteinases and its antagonists

doi:10.3877/cma.j.issn.1674-1366.2015.04.017

Abstract

Abstract:

With the continuous development of dentin adhesive technology, adhesive effect has also been greatly improved, but the adhesive interface is still affected by many factors. The hydrophilic and acidic monomers of current dentin adhesives have made hybrid layer highly prone to water sorption. This, in turn, causes polymer degradation. These unstable polymers inside the hybrid layer may result in denuded collagen fibers, which become vulnerable to mechanical and hydrolytical fatigue, as well as degradation by host-derived the matrix metalloproteinases(MMPs)with collagenolytic activity. Therefore, MMPs have a crucial role in the degradation of typeⅠcollagen, thus affecting the durability of the dentin adhesive. The purpose of this review is to summarize the progress on the biodegraded mechanism of resin-dentin adhesive interface mediated by MMPs and the application of its antagonists.

Key words: Dentin adhesive, Biodegradation, Matrix metalloproteinases, Enzyme inhibitor, Durability

Su Sun, Yuhong Xiao. The progress on the biodegradation of resin-dentin adhesive interface mediated by the matrix metalloproteinases and its antagonists[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2015, 09(04): 333-336.

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