Abstract:
Objective
To investigate the median effective dose （ED50） and the 95 percentile effective dose （ED95） of sevoflurane through nasal cannula for pediatric frenulotomy of ankyloglossia.
Methods
One hundred and forty pediatri cases， scheduled for selective frenulotomy for ankyloglossia，were randomly divided into A， B， C， D， E， Fand G groups according to the sevoflurane concentrations（2.0%、2.5%、3%、3.5%、4%、4.5%、5%） through nasal cannulas （n=20 for each group）. Anesthesia was induced with 8% sevoflurane delivered in 100% oxygen via face mask for peripheral intravenous access， then maintained with different concentration of sevoflurane through nasal cannula. Frenulotomy for ankyloglossia started after the inspired concentration of sevoflurane was adjusted to maintenance concentration for 10 min. periopertative heart rates， blood pressure， desaturation to SpO2 ＜95% and the occurrence of movements were recorded. The ED50 and ED95 of sevoflurane and 95% confidence interval （CI） were determined by probit method.
Results
Movements in response to incision reduced at the higher sevoflurane concentration. The rates of successful skin incision were 30% for group A， 45%for group B， 55% for group C， 65% for group D， 95% for group E， 100% for group F， 100% for group G. The ED50 and ED95（95% CI） of sevoflurane concentration were 2.71%（2.37%～2.96%） and 4.32%（3.93% ～5.03%） respectively.
Conclusion
The ED50 and ED95 of inspired concentration of sevoflurane through nasal cannula were 2.71% and 4.32%.
Key words:
Sevoflurane,
Nasal cannula,
Ankyloglossia,
Dose-response relationship
Yulin Jin, Wenhua Zhang, Zengfang Zhang, Ke Chen, Yiyang Chen, Liumei Chen, Xinrong Song. Dose-effect relationship in inspired concentration of sevoflurane for pediatric frenulotomy for ankyloglossia through the nasal cannula[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2014, 8(04): 330-333.