Expression and clinical significance of TGF-β1， MAPK in salivary adenoid cystic carcinoma

doi:10.3877/cma.j.issn.1674-1366.2012.06.004

Abstract

Abstract:

Objective

To investigate the expression of TGF-β1， MAPK （p-ERK1/2， p-p38 and p-JNK） in human salivary adenoid cystic carcinoma （SACC） tissues， and to explore their association and relation with clinical-pathological features.

Methods

SP immunochemistry staining method was applied to detect protein expression of TGF-β1， MAPK in the paraffin-embedded specimens from 27 cases of human SACC and 15 cases of normal human salivary epithelial tissues. All data were analyzed by SPSS 17.0 software package.

Results

The positive expression of TGF-β1， MAPK in SACC tissues increased compared with that in normal salivary tissues （P ＜0.01， P ＜0.01， P ＜0.01 and P ＜0.05 respectively）. Positive expression rates of TGF-β1， p-ERK1/2 and p-p38 at the third and forth phases was higher than that at the first and second phases in SACC （P ＜0.01， P ＜0.05 and P ＜0.05 respectively）， except p-JNK （P ＞0.05）； their expression was not obviously correlated with patient's other clinical-pathological features （P ＞0.05）； TGF-β1 had a positive relationship with MAPK in protein expression in SACC （r=0.819， P ＜0.001， r=0.728， P ＜0.001 and r=0.640， P ＜0.05 respectively）.

Conclusions

Increased expression of TGF-β1， MAPK may be associated with clinical progression of SACC， and they may participate in the process of SACC initiation， progression， invasion and metastasis by TGF-β1 activated MAPK.

Key words: Adenoid cystic carcinoma, Transforming growth factor-β1, Mitogen activated protein kinase, Immunohistochemistry, Clinicopathological significance

Hong-liang XIE, Bin ZHANG, Zhi-ying XU, Qi-Xiang LIANG. Expression and clinical significance of TGF-β1， MAPK in salivary adenoid cystic carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2012, 06(06): 497-502.

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Figures/Tables 10

References 20

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组别	例数	TGF-β1						p-ERK1/2
组别	例数	-	+	++	+++	阳性率（%）	P	-	+	++	+++	阳性率（%）	P
SACC 组	27	6	2	8	11	77.78		7	2	10	8	81.48
对照组	15	9	3	3	0	40.00	0.009	12	2	1	0	20.00	0.002
组别	例数	p-p38						p-JNK1/2
组别	例数	-	+	++	+++	阳性率（%）	P	-	+	++	+++	阳性率（%）	P
SACC 组	27	3	5	7	12	88.89		8	9	7	3	70.37
对照组	15	11	3	1	0	26.67	0.000	11	3	1	0	26.67	0.042

组别	例数	TGF-β1						p-ERK1/2
组别	例数	-	+	++	+++	阳性率（%）	P	-	+	++	+++	阳性率（%）	P
SACC 组	27	6	2	8	11	77.78		7	2	10	8	81.48
对照组	15	9	3	3	0	40.00	0.009	12	2	1	0	20.00	0.002
组别	例数	p-p38						p-JNK1/2
组别	例数	-	+	++	+++	阳性率（%）	P	-	+	++	+++	阳性率（%）	P
SACC 组	27	3	5	7	12	88.89		8	9	7	3	70.37
对照组	15	11	3	1	0	26.67	0.000	11	3	1	0	26.67	0.042

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