Abstract:

Objective

To investigate the methods， short-term effect and the complications of iodine-125 interstitial implantation in treating oral cancer.

Methods

From Jun.2009 to Jun. 2011， six oral cancer patients from department of stomatology， the First Affiliated Hospital of Sun Yat-sen University， had the treatment of CT-guided iodine-125 interstitial implantation. CT scanned to evaluate the outcomes 1 ～4 months later. The period of following-up survey is 6 ～19 months.

Results

The seeds were implanted successfully in 6 patients and average number of implant is 25.6. The iodine-125 seeds distributed well according to TPS in 5 cases. 1 case had some defect as CT scanned after implantation， 9 seeds were implanted 7 days later. TPS dose verification around tumor is 90 ～140 Gy. Low dosage area and inferior focus of four tongue cancer patients had external irradiation of 40 ～46 Gy. All patients have CT scanned after 1 ～4 months and were followed up for 6 ～19 months， no recurring was seen in the target area. Transient hemorrhage occurred in 2 patients and dysphagia in 3 patients. No radiation injury in long-term.

Conclusion

In short-term outcome， CT-guided iodine-125 implantation is effective and safety in treating oral cancer， with minimal invasive and slight complications.

Key words: Oral carcinoma, Interstitial radiotherapy, Iodine-125 implantation