Effect of sodium hyaluronate on the level of matrix metalloproteinase-2 and matrix metalloproteinase-3 in synovial fluid of patient with temporamandibular joint osteoarthritis

doi:10.3877/cma.j.issn.1674-1366.2011.04.003

Abstract

Abstract:

Objective

To study the change of matrix metalloproteinase-2 （MMP-2） and matrix metalloproteinase-3 （MMP-3） level in temporamandibular joint （TMJ） synovial fluid after sodium hyaluronate （SH） irrigation in temporamandibular joint osteoarthritis （TMJOA） patients.

Methods

Thirty patients suffered from TMJOA were randomly devided into two groups， treated respectively with lavage and SH injection for the trail group and only lavage for the control group.The MMP-2 and MMP-3 level was examined before and after the treaments.

Results

The clinical effect of the trail group was better than that of the control group （the opening degree：P ＜0.01，VAS：P ＜0.05）； A small amount of MMP-2 （31.12 μg/L） and MMP-3 （13.32 μg/L） were detected in one case of asymptomatic volunteers； The change of MMP-2， 3 level in the trail group was higher than that in control group.

Conclusion

SH may slow the destruction of articular cartilage matrix by reducing the MMP-2， 3 level in TMJ SF in TMJOA patients， thus plays a role in the treatment of TMJOA.

Key words: Temporamandibular joint osteoarthritis, Sodium hyaluronate, Matrix metallo-proteinase-2, Matrix metalloproteinase-3

Pei-cai LIU, Dong WANG, Cheng PENG, Le CHEN, Yuan ZHANG. Effect of sodium hyaluronate on the level of matrix metalloproteinase-2 and matrix metalloproteinase-3 in synovial fluid of patient with temporamandibular joint osteoarthritis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2011, 5(04): 356-360.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2011.04.003

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2011/V5/I04/356

Figures/Tables 3

组别	例数	年龄（ $\bar{x}$ ± s，岁）	男女比例
对照组	6	37.50 ± 2.16	3 ∶ 3
Ⅰ组	15	37.53 ± 5.55	7 ∶ 8
Ⅱ组	15	39.46 ± 6.63	6 ∶ 9

组别	例数	年龄（ $\bar{x}$ ± s，岁）	男女比例
对照组	6	37.50 ± 2.16	3 ∶ 3
Ⅰ组	15	37.53 ± 5.55	7 ∶ 8
Ⅱ组	15	39.46 ± 6.63	6 ∶ 9

组别	例数	开口度			VAS
组别	例数	治疗前	治疗后	t	治疗前	治疗后	t
Ⅰ组	15	2.57 ± 0.47	3.26 ± 0.25	6.151^b	4.87 ± 1.04	2.85 ± 0.45	9.998^b
Ⅱ组	15	2.68 ± 0.34	2.94 ± 0.13	3.535^b	4.99 ± 0.92	3.28 ± 0.43	6.709^b
t		0.750^a	4.303^b		0.335^a	2.682^c

组别	例数	MMP-2				MMP-3
组别	例数	治疗前	治疗后	差值	t	治疗前	治疗后	差值	t
Ⅰ组	15	382.81 ± 25.55	186.40 ± 59.19	195.80 ± 57.71	13.112^b	70.05 ± 7.89	45.48 ± 8.06	24.57 ± 12.31	7.732^b
Ⅱ组	15	379.40 ± 15.82	361.45 ± 24.07	19.53 ± 32.06	2.130^a	71.01 ± 10.81	69.32 ± 9.25	1.62 ± 3.56	1.838^a
t		0.235^a	10.610^b	10.341^b		0.276^a	7.524^b	6.936^b

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