目的

研究他克莫司溶液和地塞米松溶液对口腔扁平苔藓（OLP）的短期疗效和安全性。

方法

60 例OLP 患者随机分为两组，分别给予0.0015%他克莫司溶液（30 例）和0.002%地塞米松溶液（30 例），每日2 次含漱及口服治疗4 周，治疗结束时评价有效率和不良反应发生率。

结果

两组治疗有效率分别为83.3%、63.3%，他克莫司对OLP 的短期疗效明显优于地塞米松（χ²=4.36，P=0.038），但不良反应的发生率无明显差异（χ²=0.00，P=0.69）。

结论

他克莫司对OLP 的短期疗效明显优于地塞米松，值得在临床推广应用，但远期疗效还有待进一步观察研究。

Objective

To compare the short-term therapeutic effect of Tacrolimus solution and Dexamethasone solution on patients with oral lichen planus （OLP）.

Methods

A total of 60 patients were randomly divided into 2 groups. 30 patients were treated with 0.0015% Tacrolimus solution twice a day， while the others were treated with 0.002% Dexamethasone solution twice a day. The efficacy and the side-effect rate were graded after 4 weeks.

Results

The treatment effective rate of both two groups was 83.3% and 63.3%， respectively. The short-term healing rate of Tacralimus group was higher than that of Dexamethasone group （χ²=4.36，P = 0.038）. However， no significant difference was observed between two groups as for the side-effect occurrence （χ²=0.00，P = 0.69）.

Conclusion

There was a higher short-term therapeutic effective rate in Tacralimus group than Dexamethasone group.