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中华口腔医学研究杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 203 -207. doi: 10.3877/cma.j.issn.1674-1366.2022.04.001

所属专题: 总编推荐 口腔医学

口腔扁平苔藓专栏·专家论坛

口腔扁平苔藓的治疗进展
陈晰娟1, 夏娟1,()   
  1. 1. 中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州 510055
  • 收稿日期:2022-06-15 出版日期:2022-08-01
  • 通信作者: 夏娟

The treatment progress of the oral lichen planus

Xijuan Chen1, Juan Xia1,()   

  1. 1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2022-06-15 Published:2022-08-01
  • Corresponding author: Juan Xia
  • Supported by:
    The Guangdong Basic and Applied Basic Research Foundation(2021A1515111020)
引用本文:

陈晰娟, 夏娟. 口腔扁平苔藓的治疗进展[J/OL]. 中华口腔医学研究杂志(电子版), 2022, 16(04): 203-207.

Xijuan Chen, Juan Xia. The treatment progress of the oral lichen planus[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(04): 203-207.

口腔扁平苔藓(OLP)是一种病因复杂的口腔黏膜慢性炎症性疾病,属于口腔潜在恶性疾患(OPMD)范畴。药物治疗是目前OLP的主要治疗手段,尽管多种新型免疫抑制剂被广泛应用于OLP的治疗,但仍存在部分病例顽固难治、易复发,少数病例迁延恶变等现象。探索新的治疗药物及治疗手段,是解决当前困境的关键。随着现代生物技术及医学设备的发展,生物制剂、光动力疗法及光生物调节疗法等新兴治疗方式逐渐被应用于OLP的临床治疗。本文通过回顾文献,就近年OLP的治疗进展做一简要概述。

Oral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa with complex etiology, which belongs to the category of oral potential malignant disorders. At present, drug therapy is the main treatment of OLP. Although a variety of new immunosuppressive agents are widely used in OLP treatment, some cases are still difficult to treat and easy to relapse, and a few cases end up with malignant transformation. Exploring new therapeutic drugs and methods is the key to solve the current dilemma. With the development of modern biotechnology and medical equipment, the biological agents, photodynamic therapy and photobiomodulation therapy are gradually applied to the clinical treatment of OLP. This article reviews the recent literature and provides a brief overview of the treatment progress of OLP.

[1]
中华口腔医学会口腔黏膜病学专业委员会,中华口腔医学会中西医结合专业委员会.口腔扁平苔藓诊疗指南(修订版)[J].中华口腔医学杂志202257(2):115-121. DOI:10.3760/cma.j.cn112144-20211115-00505.
[2]
Su ZHu JCheng B,et al. Efficacy and safety of topical administration of tacrolimus in oral lichen planus:An updated systematic review and meta-analysis of randomized controlled trials[J]. J Oral Pathol Med202251(1):63-73. DOI:10.1111/jop.13217.
[3]
Ladda MSandhu VIghani A,et al. Off-label uses of topical pimecrolimus[J]. J Cutan Med Surg201923(4):442-448. DOI:10.1177/1203475419847950.
[4]
da Silva ELde Lima TBRados PV,et al. Efficacy of topical non-steroidal immunomodulators in the treatment of oral lichen planus:A systematic review and meta-analysis[J]. Clin Oral Investig202125(9):5149-5169. DOI:10.1007/s00784-021-04072-7.
[5]
刘晓慧,刘永红,张晓光,等.康复新液与他克莫司联合沙利度胺治疗口腔扁平苔藓的疗效及安全性分析[J].现代生物医学进展202020(15):2971-2974. DOI:10.13241/j.cnki.pmb.2020.15.035.
[6]
Wu YZhou GZeng H,et al. A randomized double-blind,positive-control trial of topical thalidomide in erosive oral lichen planus[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010110(2):188-195. DOI:10.1016/j.tripleo.2010.03.034.
[7]
Lajevardi VGhodsi SZHallaji Z,et al. Treatment of erosive oral lichen planus with methotrexate[J]. J Dtsch Dermatol Ges201614(3):286-293. DOI:10.1111/ddg.12636.
[8]
Husein-ElAhmed HGieler USteinhoff M. Lichen planus:A comprehensive evidence-based analysis of medical treatment[J]. J Eur Acad Dermatol Venereol201933(10):1847-1862. DOI:10.1111/jdv.15771.
[9]
苏秋霞.他克莫司软膏联合胸腺肽治疗慢性乙型肝炎合并口腔扁平苔藓的疗效及对患者免疫功能的影响[J].内科201813(4):599-602. DOI:10.16121/j.cnki.cn45-1347/r.2018.04.18.
[10]
Salehi BLopez-Jornet PPons-Fuster López E,et al. Plant-derived bioactives in oral mucosal lesions:A key emphasis to curcumin,lycopene,chamomile,aloe vera,green tea and coffee properties[J]. Biomolecules20199(3):106. DOI:10.3390/biom9030106.
[11]
Ghahremanlo ABoroumand NGhazvini K,et al. Herbal medicine in oral lichen planus[J]. Phytother Res201933(2):288-293. DOI:10.1002/ptr.6236.
[12]
Luo YKuai LChen J,et al. Efficacy and safety of Tripterygium wilfordii Hook. f. for oral lichen planus:Evidence from 18 randomized controlled trials[J]. Phytother Res202034(9):2180-2191. DOI:10.1002/ptr.6672.
[13]
Nasr MMEbrahim HMKhattab FM,et al. Bacillus calmette-guerin,polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus[J]. Dermatol Ther201831(3):e12591. DOI:10.1111/dth.12591.
[14]
Balestri RBortolotti RRech G,et al. Treatment of oral erosive lichen planus with upadacitinib[J]. JAMA Dermatol2022158(4):457-458. DOI:10.1001/jamadermatol.2022.0147.
[15]
Moussa AColla TMorrison B,et al. Effective treatment of oral lichen planus with the JAK inhibitor baricitinib[J]. Australas J Dermatol202263(2):276-277. DOI:10.1111/ajd.13811.
[16]
孙雨桐,江潞.生物制剂在口腔扁平苔藓治疗中的应用[J].口腔医学202242(3):261-265. DOI:10.13591/j.cnki.kqyx.2022.03.014.
[17]
Mahmoud MMAfifi MM. Anti-angiogenic therapy(bevacizumab)in the management of oral lichen planus[J]. Eur J Oral Sci2016124(2):119-126. DOI:10.1111/eos.12251.
[18]
Jiang HLi JWang L,et al. Total glucosides of paeony:A review of its phytochemistry,role in autoimmune diseases,and mechanisms of action[J]. J Ethnopharmacol2020258:112913. DOI:10.1016/j.jep.2020.112913.
[19]
娄依婷,陶然,李勇正,等.基于网络药理学研究白芍总苷治疗口腔扁平苔癣的作用机制[J].中成药202244(3):1005-1010. DOI:10.3969/j.issn.1001-1528.2022.03.060.
[20]
李梅.他克莫司软膏与白芍总苷治疗口腔扁平苔藓的临床疗效分析[J].实用临床医药杂志201620(19):152-153. DOI:10.7619/jcmp.201619056.
[21]
Hashem ASIssrani RElsayed TEE,et al. Topical hyaluronic acid in the management of oral lichen planus:A comparative study[J]. J Investig Clin Dent201910(2):e12385. DOI:10.1111/jicd.12385.
[22]
Agha-Hosseini FAtyabi FAkbari K,et al. Decreased recurrence of symptoms in oral lichen planus with intralesional injection of hyaluronic acid and triamcinolone[J]. Int J Oral Maxillofac Surg202150(12):1643-1648. DOI:10.1016/j.ijom.2021.02.028.
[23]
Zanetta POrmelli MAmoruso A,et al. Probiotics as potential biological immunomodulators in the management of oral lichen planus:What′s new?[J]. Int J Mol Sci202223(7):3489. DOI:10.3390/ijms23073489.
[24]
Han XZhang JTan Y,et al. Probiotics:A non-conventional therapy for oral lichen planus[J]. Arch Oral Biol201781:90-96. DOI:10.1016/j.archoralbio.2017.04.026.
[25]
Keller MKKragelund C. Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients[J]. Oral Dis201824(6):1107-1114. DOI:10.1111/odi.12858.
[26]
Li YShao FZheng S,et al. Alteration of Streptococcus salivarius in buccal mucosa of oral lichen planus and controlled clinical trial in OLP treatment[J]. Probiotics Antimicrob Proteins202012(4):1340-1348. DOI:10.1007/s12602-020-09664-5.
[27]
Marlina EGoodman RNMercadante V,et al. A proof of concept pilot trial of probiotics in symptomatic oral lichen planus (CABRIO)[J]. Oral Dis2021. DOI:10.1111/odi.14014.
[28]
Al-Hallak NHamadah OMouhamad M,et al. Efficacy of injectable platelet-rich fibrin in the treatment of symptomatic oral lichen planus[J]. Oral Dis2022. DOI:10.1111/odi.14261.
[29]
He YDeng JZhao Y,et al. Efficacy evaluation of photodynamic therapy for oral lichen planus:A systematic review and meta-analysis[J]. BMC Oral Health202020(1):302. DOI:10.1186/s12903-020-01260-x.
[30]
Wang BFan JWang L,et al. Photobiomodulation therapy/photodynamic therapy versus steroid therapy for oral lichen planus:A systematic review and meta-analysis[J]. Photobiomodul Photomed Laser Surg202139(3):145-154. DOI:10.1089/photob.2020.4930.
[31]
Amanat DEbrahimi HZahedani MZ,et al. Comparing the effects of cryotherapy with nitrous oxide gas versus topical corticosteroids in the treatment of oral lichen planus[J]. Indian J Dent Res201425(6):711-716. DOI:10.4103/0970-9290.152166.
[32]
戈春城,童国勇,徐佳.口腔修复膜在手术治疗口腔扁平苔藓中的疗效评价[J].临床口腔医学杂志201531(6):350-351. DOI:10.3969/j.issn.1003-1634.2015.06.012.
[33]
Tarasenko SStepanov MMorozova E,et al. High-level laser therapy versus scalpel surgery in the treatment of oral lichen planus:A randomized control trial[J]. Clin Oral Investig202125(10):5649-5660. DOI:10.1007/s00784-021-03867-y.
[34]
Li KHe WHua H. Characteristics of the psychopathological status of oral lichen planus:A systematic review and meta-analysis[J]. Aust Dent J202267(2):113-114. DOI:10.1111/adj.12896.
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