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中华口腔医学研究杂志(电子版) ›› 2013, Vol. 07 ›› Issue (01) : 71 -74. doi: 10.3877/cma.j.issn.1674-1366.2013.01.015

综述

微小RNA 与牙周炎
郑倩琪1, 李劲松1,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院口腔科
  • 收稿日期:2012-07-23 出版日期:2013-02-01
  • 通信作者: 李劲松
  • 基金资助:
    国家自然科学基金(81072225、81272951)

Roles of microRNAs in periodontitis

Qian-qi ZHENG1, Jin-song LI1,()   

  1. 1. Department of Stomatology,Sun Yet-sen Memorial Hospital (Second Affiliated Hospital),Sun Yat-sen University,Guangzhou 510120,China
  • Received:2012-07-23 Published:2013-02-01
  • Corresponding author: Jin-song LI
引用本文:

郑倩琪, 李劲松. 微小RNA 与牙周炎[J/OL]. 中华口腔医学研究杂志(电子版), 2013, 07(01): 71-74.

Qian-qi ZHENG, Jin-song LI. Roles of microRNAs in periodontitis[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2013, 07(01): 71-74.

近十年,一类非编码蛋白的小RNA 分子——微小RNA(miRNAs)证实参与免疫细胞发育以及多种疾病如肿瘤、炎症等生理和病理过程。 而牙周炎作为危害人类口腔健康的常见慢性炎症,其发病机制的研究尚有不确切之处,也未能找到十分有效的治疗方法。 近年,学者开始对牙周炎及miRNAs 两者间的关系开展研究,以探索miRNAs 参与牙周炎的发病机制。 本文根据miRNAs 与牙周炎研究的最新进展,就其在牙周组织及牙槽骨组织中异常表达及可能机制两方面作一综述。

In the recent decade,microRNAs (miRNAs),a kind of small non-coding ribonucleic acid (RNA) molecules,had been confirmed to play a certain role in various physiological processes like the development of immune cells. MiRNAs expression has been shown to affect the pathobiology of several diseases such as cancer and inflammatory diseases including lupus and rheumatoid arthritis.Nevertheless,the expression of miRNAs in periodontal tissues and their potential function in the context of the pathobiology of periodontal diseases are largely unexplored. Recently,studies have been done to explore the relationship between periodontitis and miRNAs in order to find out the influence of miRNAs in the pathogenesis of periodontitis. This article expounds the latest progress on researches of miRNAs and periodontitis,focusing on the differential expression of miRNAs in periodontal tissue and alveolar bone tissue. The possible mechanism of periodontitis which is regulated by miRNAs is also discussed.

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