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中华口腔医学研究杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 153 -159. doi: 10.3877/cma.j.issn.1674-1366.2025.03.002

专家笔谈

酸敏感离子通道3在颅颌面疼痛中分子调控机制研究进展
杨虹1, 林佳雨1, 肖轺穆1, 戴静桃1, 刘楚峰1,()   
  1. 1. 南方医科大学口腔医院正畸科,广州 510280
  • 收稿日期:2025-02-19 出版日期:2025-06-01
  • 通信作者: 刘楚峰
  • 基金资助:
    广东省研究生教育创新计划(2023JGXM-023)广州市科技计划(202201010878)

Research progress on the molecular regulatory mechanism of acid-sensing ion channel 3 in craniofacial pain

Hong Yang1, Jiayu Lin1, Yaomu Xiao1, Jingtao Dai1, Chufeng Liu1,()   

  1. 1. Department of Orthodontics,Stomatological Hospital,Southern Medical University,Guangzhou 510280,China
  • Received:2025-02-19 Published:2025-06-01
  • Corresponding author: Chufeng Liu
引用本文:

杨虹, 林佳雨, 肖轺穆, 戴静桃, 刘楚峰. 酸敏感离子通道3在颅颌面疼痛中分子调控机制研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(03): 153-159.

Hong Yang, Jiayu Lin, Yaomu Xiao, Jingtao Dai, Chufeng Liu. Research progress on the molecular regulatory mechanism of acid-sensing ion channel 3 in craniofacial pain[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(03): 153-159.

口颌面部疼痛被定义为头颈部、口腔颜面部或各种口腔组织来源疼痛的总称,是口腔常见病症。酸敏感离子通道3(ASIC3)主要分布在外周感觉神经元,参与伤害性感受、机械感觉和化学感觉,是疼痛相关的组织酸中毒的分子决定因素。研究ASIC3在口颌面部疼痛中的作用对研究疼痛机理有重要意义。本文系统梳理了近年来ASIC3 在口颌面部疼痛中的作用及其镇痛作用的研究进展,以期为临床治疗和药物研制提供新思路,为口颌面部疼痛的精准治疗开辟新路径。

Oral and maxillofacial pain,defined as the pain originating from the head and neck,oral and facial regions or various oral tissues,is a common oral condition.Acid-sensing ion channel 3(ASIC3),mainly distributed in peripheral sensory neurons,participates in nociception,mechanosensation and chemosensation,and is a molecular determinant of tissue acidosis-related pain. Studying the role of ASIC3 in oral and maxillofacial pain is of great significance for understanding the mechanism of pain.This article reviews the research progress on the role of ASIC3 in oral and maxillofacial pain and its analgesic effect in recent years.

图1 酸敏感离子通道3(ASIC3)参与颌面部疼痛调控相关的分子机制图 口腔颌面部疼痛传导经外周神经传入三叉神经节(TG)、三叉神经尾侧核(TNC)。ASIC3分布于传导通路上,质子(H+)或2-胍-4-甲基喹唑啉(GMQ)可以激活ASIC3,其中GMQ对钙离子(Ca2+)敏感,降低Ca2+浓度将增强GMQ诱导的电流。PDL:牙周膜;红箭头示神经传导。
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