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中华口腔医学研究杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 145 -152. doi: 10.3877/cma.j.issn.1674-1366.2025.03.001

专家笔谈

鼻咽癌放疗前的口腔准备
欧阳凯彤1, 李静远1, 杜宇1,()   
  1. 1. 中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广东省口腔疾病临床医学研究中心,广州 510055
  • 收稿日期:2025-02-23 出版日期:2025-06-01
  • 通信作者: 杜宇

Pre - radiotherapy oral preparation of nasopharyngeal carcinoma

Kaitong Ouyang1, Jingyuan Li1, Yu Du1,()   

  1. 1. Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangdong Provincial Clinical Research Center of Oral Diseases,Guangzhou 510055,China
  • Received:2025-02-23 Published:2025-06-01
  • Corresponding author: Yu Du
引用本文:

欧阳凯彤, 李静远, 杜宇. 鼻咽癌放疗前的口腔准备[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(03): 145-152.

Kaitong Ouyang, Jingyuan Li, Yu Du. Pre - radiotherapy oral preparation of nasopharyngeal carcinoma[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(03): 145-152.

鼻咽癌(NPC)是我国发病率较高的一类口腔-颌面头颈部恶性肿瘤。放疗是NPC 的根治手段,可能引起放射性颌骨坏死、黏膜炎、口干症和放射性龋坏等口腔不良反应。NPC 放疗前如未进行合理规范的口腔准备,不仅严重影响患者的口腔健康,继而降低生活质量,还会增加后续口腔治疗的复杂性和难度,难以达到理想疗效。NPC 放疗前完善的口腔准备对医患双方均具有积极意义,然而现阶段多数口腔医师对NPC放疗前口腔准备的涵盖内容和治疗时机均不清楚。本文针对NPC 放疗常见的口腔不良反应,NPC 放疗前口腔准备的意义与目标,以及放疗前的口腔准备措施进行了梳理和总结,旨在为临床提供参考依据。

Nasopharyngeal carcinoma (NPC) is a prevalent oral-maxillofacial head and neck cancer in China.Radiotherapy,the radical treatment for NPC,often causes oral adverse effects including osteoradionecrosis, mucositis,xerostomia and radiotherapy related caries. Inadequate pre -radiotherapy oral preparation not only impairs patients' oral health and subsequently reduces the quality of life,but also increases the complexity and difficulty of subsequent dental treatment,thus hindering optimal therapeutic outcome. Preradiotherapy oral preparation is of positive significance for both patients and dentists,but most dentists have limited knowledge of the content and timing of pre-radiotherapy oral preparation currently. This review summarizes common oral complications of radiotherapy,the significance,objectives and specific measures of oral preparation for NPC,aiming to provide clinical reference.

图1 鼻咽癌放疗并发症的风险因素
图2 鼻咽癌放疗前的口腔治疗方案及时机
[1]
Chen YP,Chan ATC,Le QT,et al. Nasopharyngeal carcinoma[J]. Lancet,2019,394(10192):64-80. DOI:10.1016/s0140-6736(19)30956-0.
[2]
Chow LQM.Head and neck cancer[J].N Engl J Med,2020,382(1):60-72.DOI:10.1056/NEJMra1715715.
[3]
康敏.中国鼻咽癌放射治疗指南(2022 版)[J].中华肿瘤防治杂志,2022,29(9):611-622. DOI:10.16073/j.cnki.cjcpt.2022.09.01.
[4]
International Agency for Research on Cancer. Data visualization tools for exploring the global cancer burden in 2022[EB/OL].[2025-01-10].https://gco.iarc.who.int/today/en.
[5]
Baskar R,Lee KA,Yeo R,et al. Cancer and radiation therapy:Current advances and future directions[J].Int J Med Sci,2012,9(3):193-199.DOI:10.7150/ijms.3635.
[6]
Zhang B,Mo Z,Du W,et al. Intensity-modulated radiation therapy versus 2D - RT or 3D - CRT for the treatment of nasopharyngeal carcinoma:A systematic review and Meta -analysis[J]. Oral Oncol,2015,51(11):1041-1046. DOI:10.1016/j.oraloncology.2015.08.005.
[7]
Tang LL,Chen L,Xu GQ,et al. Reduced-volume radiotherapy versus conventional - volume radiotherapy after induction chemotherapy in nasopharyngeal carcinoma:An open - label,noninferiority,multicenter,randomized phase 3 trial[J]. CA Cancer J Clin,2025,75(3):203-215.DOI:10.3322/caac.21881.
[8]
中国抗癌协会肿瘤营养专业委员会,中华医学会肠外肠内营养学分会.鼻咽癌患者的营养治疗共识[J].肿瘤代谢与营养电子杂志,2021,8(6):600-604.
[9]
Lee HM,Okuda KS,González FE,et al. Current perspectives on nasopharyngeal carcinoma[J]. Adv Exp Med Biol,2019,1164:11-34.DOI:10.1007/978-3-030-22254-3_2.
[10]
Yanaguizawa WH,Kobayashi-Velasco S,Gialain IO,et al.Endodontic treatment in patients previously subjected to head and neck radiotherapy:A literature review[J]. J Oral Diag,2019,4:e20190001.DOI:10.5935/2525-5711.20190001.
[11]
中国抗癌协会肿瘤放射防护专业委员会,中华预防医学会放射卫生专业委员会. 放射性口腔黏膜炎辐射防护专家共识[J]. 中华放射肿瘤学杂志,2024,33(4):296-306. DOI:10.3760/cma.j.cn113030-20240105-00006.
[12]
Song X,Su L,Lin Q,et al. Effect of nutritional status before radiotherapy on radiation-induced acute toxicities in patients with nasopharyngeal carcinoma[J]. Head Neck,2023,45(3):620-628.DOI:10.1002/hed.27275.
[13]
Liu Z,Huang L,Wang H,et al. Predicting nomogram for severe oral mucositis in patients with nasopharyngeal carcinoma during intensity-modulated radiation therapy:A retrospective cohort study[J]. Curr Oncol,2022,30(1):219-232. DOI:10.3390/curroncol30010017.
[14]
何悦,侯劲松,李晓光,等.下颌骨放射性骨坏死临床诊疗专家共识[J].中国口腔颌面外科杂志,2017,15(5):445-456.DOI:10.19438/j.cjoms.2017.05.015.
[15]
韩煜,何悦.放射性颌骨坏死的病因学研究进展[J].口腔医学,2020,40(4):362-365.DOI:10.13591/j.cnki.kqyx.2020.04.015.
[16]
何悦.放射性颌骨坏死诊治的昨天、今天和明天[J].中华口腔医学杂志,2021,56(5):410-414.DOI:10.3760/cma.j.cn112144-20210122-00035.
[17]
See Toh YL,Soong YL,Chim YX,et al. Dental extractions for preradiation dental clearance and incidence of osteoradionecrosis in patients with nasopharyngeal carcinoma treated with intensitymodulated radiotherapy[J]. J Investig Clin Dent,2018,9(2):e12295.DOI:10.1111/jicd.12295.
[18]
Somay E,Topkan E,Kucuk A,et al. Pre-chemoradiotherapy high platelet counts predict jaw osteoradionecrosis in locally advanced nasopharyngeal carcinoma patients[J].J Stomatol Oral Maxillofac Surg,2024,125(3s):101838.DOI:10.1016/j.jormas.2024.101838.
[19]
陈东,杨征,蒋丽.放射性口腔干燥症的评估与临床管理的研究进展[J]. 国际口腔医学杂志,2019,46(6):711-717. DOI:10.7518/gjkq.2019101.
[20]
Sim CP,Wee J,Xu Y,et al. Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients [J]. Clin Oral Investig,2015,19(5):1005-1011. DOI:10.1007/s00784-014-1318-y.
[21]
Yang K,Xie W,Zhang X,et al. A nomogram for predicting late radiation - induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era[J]. Aging(Albany NY),2021,13(14):18645-18657.DOI:10.18632/aging.203308.
[22]
王英鑫,王帅,张霓霓,等. 放射性涎腺损伤治疗的研究进展[J].临床口腔医学杂志,2017,33(11):696-699.DOI:10.3969/j.issn.1003-1634.2017.11.019.
[23]
李贤玉,陈文霞.放射性龋的发病机制及诊疗要点[J].中华口腔医学杂志,2024,59(1):30-36.DOI:10.3760/cma.j.cn112144-20231016-00199.
[24]
Yang J,Yang L,Han Q,et al. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life[J].Open Med(Wars),2023,18(1):20230673.DOI:10.1515/med-2023-0673.
[25]
Li Z,Wu Q,Meng X,et al. Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients[J]. Sci Rep,2021,11(1):12283. DOI:10.1038/s41598-021-91600-w.
[26]
Lieshout HF,Bots CP. The effect of radiotherapy on dental hard tissue:A systematic review[J]. Clin Oral Investig,2014,18(1):17-24.DOI:10.1007/s00784-013-1034-z.
[27]
Liang X,Zhang J,Peng G,et al. Radiation caries in nasopharyngeal carcinoma patients after intensity - modulated radiation therapy:A cross-sectional study[J].J Dent Sci,2016,11(1):1-7.DOI:10.1016/j.jds.2015.09.003.
[28]
Jensen SB,Vissink A,Limesand KH,et al. Salivary gland hypofunction and xerostomia in head and neck radiation patients[J]. J Natl Cancer Inst Monogr,2019(53):lzg016. DOI:10.1093/jncimonographs/lgz016.
[29]
Kielbassa AM,Hinkelbein W,Hellwig E,et al. Radiationrelated damage to dentition[J].Lancet Oncol,2006,7(4):326-335.DOI:10.1016/s1470-2045(06)70658-1.
[30]
王峥,程磊,周学东,等.放射性龋形成机制的研究进展[J].口腔疾病防治,2019,27(4):255-259.DOI:10.12016/j.issn.2096-1456.2019.04.010.
[31]
Verginadis II,Citrin DE,Ky B,et al. Radiotherapy toxicities:Mechanisms,management,and future directions[J]. Lancet,2025,405(10475):338-352. DOI:10.1016/s0140-6736(24)02319-5.
[32]
de Ruysscher D,Niedermann G,Burnet NG,et al. Radiotherapy toxicity[J].Nat Rev Dis Primers,2019,5(1):13.DOI:10.1038/s41572-019-0064-5.
[33]
中华医学会放射肿瘤治疗学分会.放射性口腔黏膜炎防治策略专家共识(2019)[J]. 中华放射肿瘤学杂志,2019,28(9):641-647.DOI:10.3760/cma.j.issn.1004-4221.2019.09.001.
[34]
Zheng Y,Han F,Xiao W,et al. Analysis of late toxicity in nasopharyngeal carcinoma patients treated with intensity modulated radiation therapy[J]. Radiat Oncol,2015,10:17.DOI:10.1186/s13014-014-0326-z.
[35]
Nadella KR,Kodali RM,Guttikonda LK,et al.Osteoradionecrosis of the Jaws:Clinico-therapeutic management:A literature review and update[J]. J Maxillofac Oral Surg,2015,14(4):891-901.DOI:10.1007/s12663-015-0762-9.
[36]
Li J,Zhu C,Zhang Y,et al. Incidence and risk factors for radiotherapy - induced oral mucositis among patients with nasopharyngeal carcinoma:A Meta-analysis[J].Asian Nurs Res(Korean Soc Nurs Sci),2023,17(2):70-82. DOI:10.1016/j.anr.2023.04.002.
[37]
吴莉玲,高清平,扶琼瑶,等.头颈部肿瘤患者放射性龋相关性因素分析[J]. 华西口腔医学杂志,2019,37(1):87-91. DOI:10.7518/hxkq.2019.01.017.
[38]
Licitra L,Keilholz U,Tahara M,et al. Evaluation of the benefit and use of multidisciplinary teams in the treatment of head and neck cancer[J]. Oral Oncol,2016,59:73-79. DOI:10.1016/j.oraloncology.2016.06.002.
[39]
中国抗癌协会放射治疗整合护理专业委员会,浙江省护理学会肿瘤专业委员会.放射性口腔干燥症护理专家共识[J].中华现代护理杂志,2024,30(34):4621-4627.DOI:10.3760/cma.j.cn115682-20240314-01356.
[40]
Warwas B,Cremers F,Gerull K,et al. Risk factors for xerostomia following radiotherapy of head-and-neck cancers[J].Anticancer Res,2022,42(5):2657-2663. DOI:10.21873/anticanres.15743.
[41]
van Dijk LV,Abusaif AA,Rigert J,et al. Normal tissue complication probability (NTCP) prediction model for osteoradionecrosis of the mandible in patients with head and neck cancer after radiation therapy:Large-scale observational cohort[J].Int J Radiat Oncol Biol Phys,2021,111(2):549-558.DOI:10.1016/j.ijrobp.2021.04.042.
[42]
MD Anderson Head and Neck Symptom Working Group.Mandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal - tissue complication probability(NTCP)model:External validation of right-censored clinico-dosimetric and competing risk application across international multi -institutional observational cohorts and online graphical user interface clinical support tool assessment[J/OL]. medRxiv(Preprint),2024:24312311.DOI:10.1101/2024.08.20.24312311.
[43]
Sharabiani M, Clementel E, Andratschke N, et al.Generalizability assessment of head and neck cancer NTCP models based on the TRIPOD criteria[J]. Radiother Oncol,2020,146:143-150.DOI:10.1016/j.radonc.2020.02.013.
[44]
Chen YJ,Chen SC,Wang CP,et al. Trismus,xerostomia and nutrition status in nasopharyngeal carcinoma survivors treated with radiation[J].Eur J Cancer Care(Engl),2016,25(3):440-448.DOI:10.1111/ecc.12270.
[45]
Wu VW,Lam YN. Radiation-induced temporo-mandibular joint disorder in post-radiotherapy nasopharyngeal carcinoma patients:Assessment and treatment[J]. J Med Radiat Sci,2016,63(2):124-132.DOI:10.1002/jmrs.145.
[46]
Bhatia KS,King AD,Paunipagar BK,et al. MRI findings in patients with severe trismus following radiotherapy for nasopharyngeal carcinoma[J].Eur Radiol,2009,19(11):2586-2593.DOI:10.1007/s00330-009-1445-z.
[47]
Buglione M,Cavagnini R,Di Rosario F,et al. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation:Xerostomia and trismus(Part 2).Literature review and consensus statement[J]. Crit Rev Oncol Hematol,2016,102:47-54. DOI:10.1016/j.critrevonc.2016.03.012.
[48]
Murdoch-Kinch CA,Zwetchkenbaum S. Dental management of the head and neck cancer patient treated with radiation therapy[J].J Mich Dent Assoc,2011,93(7):28-37.
[49]
黄涛.金属义齿对鼻咽癌放射治疗剂量分布的影响[J].医学理论与实践,2020,33(13):2137-2139. DOI:10.19381/j.issn.1001-7585.2020.13.035.
[50]
宋威,鹿红,马珺,等.金属伪影对鼻咽癌放疗危及器官自动勾画的影响[J]. 中国医学物理学杂志,2021,38(10):1185-1189.DOI:10.3969/j.issn.1005-202X.2021.10.001.
[51]
吴桐,程斌.肿瘤放化疗性口腔黏膜炎的防与治[J].中华口腔医学杂志,2022,57(4):436-440.DOI:10.3760/cma.j.cn112144-20220130-00038.
[52]
Watson E,Dorna Mojdami Z,Oladega A,et al.Clinical practice guidelines for dental management prior to radiation for head and neck cancer[J].Oral Oncol,2021,123:105604.DOI:10.1016/j.oraloncology.2021.105604.
[53]
周稚辉,郎淼杰,王彦亮.放疗后拔牙并发颌骨放射性骨坏死的预防策略[J]. 中华口腔医学杂志,2015,50(8):503-506.DOI:10.3760/cma.j.issn.1002-0098.2015.08.013.
[54]
Lee J,Hueniken K,Cuddy K,et al. Dental extractions before radiation therapy and the risk of osteoradionecrosis in patients with head and neck cancer[J]. JAMA Otolaryngol Head Neck Surg,2023,149(12):1130-1139. DOI:10.1001/jamaoto.2023.3429.
[55]
Normando AGC,Pérez-de-Oliveira ME,Guerra ENS,et al. To extract or not extract teeth prior to head and neck radiotherapy?A systematic review and Meta - analysis [J]. Support Care Cancer,2022,30(11):8745-8759. DOI:10.1007/s00520-022-07215-y.
[56]
潘亚萍.肿瘤患者牙周炎治疗方案的选择[J].中华口腔医学杂志,2017,52(2):77-80. DOI:10.3760/cma.j.issn.1002-0098.2017.02.005.
[57]
Beech N,Robinson S,Porceddu S,et al. Dental management of patients irradiated for head and neck cancer[J]. Aust Dent J,2014,59(1):20-28.DOI:10.1111/adj.12134.
[58]
Schiødt M,Hermund NU. Management of oral disease prior to radiation therapy[J].Support Care Cancer,2002,10(1):40-43.DOI:10.1007/s005200100284.
[59]
Shih YJ,Huang JY,Lai YC,et al. Tooth extraction within 2 weeks before radiotherapy and osteoradionecrosis:A nationwide cohort study[J].Oral Dis,2024,30(2):575-585.DOI:10.1111/odi.14349.
[60]
Goh EZ,Beech N,Johnson NR,et al. The dental management of patients irradiated for head and neck cancer[J]. Br Dent J,2023,234(11):800-804.DOI:10.1038/s41415-023-5864-z.
[61]
Aktemur Türker S,Kaşıkçı S,Uzunoğlu Özyürek E,et al. The effect of radiotherapy delivery time and obturation materials on the fracture resistance of mandibular premolars[J]. Clin Oral Investig,2021,25(3):901-905. DOI:10.1007/s00784-020-03378-2.
[62]
Davies AN,Thompson J. Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy[J].Cochrane Database Syst Rev,2015(10):CD003782. DOI:10.1002/14651858.CD003782.pub3.
[63]
孙方方,黄蓉,孟佳丽,等.数字化头颈部放疗口腔定位支架临床应用的初步评价[J]. 中华口腔医学杂志,2023,57(10):1022-1028.DOI:10.3760/cma.j.cn112144-20220701-00360.
[64]
Alves LDB,Menezes ACS,Pereira DL,et al. Benefits of intraoral stents in patients with head and neck cancer undergoing radiotherapy:Systematic review[J]. Head Neck,2021,43(5):1652-1663.DOI:10.1002/hed.26620.
[65]
索万奎.义齿软衬材料表面白色念珠菌粘附的研究进展[J].国外医学口腔医学分册,2004,31(S1):137-139. DOI:10.3969/j.issn.1008-8199.2012.04.027.
[66]
朱炳震,李碧榕,苏屹坤,等.义齿软衬材料抗菌改性的研究进展[J].口腔医学,2022,42(8):759-763.DOI:10.13591/j.cnki.kqyx.2022.08.017.
[67]
Peterson DE,Boers-Doets CB,Bensadoun RJ,et al. Management of oral and gastrointestinal mucosal injury:ESMO Clinical Practice Guidelines for diagnosis,treatment,and follow-up[J].Ann Ooncol,2015,26(Suppl 5):v139-v151. DOI:10.1093/annonc/mdv202.
[68]
Zhang L,Wang L,Wu Y,et al. Assessment and management of radiation - induced trismus in patients with nasopharyngeal carcinoma:A best practice implementation project[J]. JBI Evid Implement,2023,21(3):208-217. DOI:10.1097/xeb.00000000 00000355.
[69]
Şahan MH,Gökçe B. The evaluation of TheraBite and wooden tongue depressor in the treatment of trismus and health-related quality of life[J]. Eur Rev Med Pharmacol Sci,2023,27(4 Suppl):66-75.DOI:10.26355/eurrev_202306_32746.
[70]
Zhen Z,Yang Y,Feng C,et al.From data to decisions:Big data and AI are shaping the future of radiotherapy and individualized treatment of nasopharyngeal carcinoma[J]. Intelligent Oncology,2025,1(1):52-60.DOI:10.1016/j.intonc.2024.09.001.
[71]
张睿,金路,陈谦明,等.尺度不变特征增强深度学习在口腔黏膜病灶分割中应用的研究[J]. 中华口腔医学杂志,2025,60(3):239-247.DOI:10.3760/cma.j.cn112144-20241210-00467.
[72]
柴桢,李晔,游民黎,等.基于人工智能的多模态融合诊断——牙周炎精准诊断新进展[J].中华口腔医学杂志,2025,60(5):558-566.DOI:10.3760/cma.j.cn112144-20250110-00009.
[73]
de Araujo Faria V,Azimbagirad M,Viani Arruda G,et al.Prediction of radiation-related dental caries through PyRadiomics features and artificial neural network on panoramic radiography[J]. J Digit Imaging,2021,34(5):1237-1248. DOI:10.1007/s10278-021-00487-6.
[74]
Islam MRR,Islam R,Ferdous S,et al. Teledentistry as an effective tool for the communication improvement between dentists and patients:An overview[J]. Healthcare(Basel),2022,10(8):1586.DOI:10.3390/healthcare10081586.
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