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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 200 -205. doi: 10.3877/cma.j.issn.1674-1366.2024.03.010

综述

口腔钛种植体成骨性能的研究进展
陈天1, 李歆2, 刘开政3, 邓永强4,†()   
  1. 1. 深圳大学总医院口腔科，深圳　518055；杭州师范大学口腔医学院，杭州　311121
    2. 深圳大学总医院口腔科，深圳　518055；深圳大学口腔医学研究所，深圳　518055
    3. 中国科学院深圳先进技术研究院人体组织与器官退行性研究中心，深圳　518055
    4. 深圳大学总医院口腔科，深圳　518055；杭州师范大学口腔医学院，杭州　311121；深圳大学口腔医学研究所，深圳　518055
  • 收稿日期:2024-02-24 出版日期:2024-06-01
  • 通信作者: 邓永强

Research progress in bone osseointegration for implant dentistry

Tian Chen1, Xin Li2, Kaizheng Liu3, Yongqiang Deng4,†()   

  1. 1. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; Institute of Stomatological Research, Shenzhen University, Shenzhen 518055, China
    2. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; School of Stomatology, Hangzhou Normal University, Hangzhou 311121, China
    3. Research Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    4. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; School of Stomatology, Hangzhou Normal University, Hangzhou 311121, China; Institute of Stomatological Research, Shenzhen University, Shenzhen 518055, China
  • Received:2024-02-24 Published:2024-06-01
  • Corresponding author: Yongqiang Deng
  • Supported by:
    National Natural Science Foundation of China(81901058); Science Technology and Innovation Committee of Shenzhen Municipality(20220810163811002)
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陈天, 李歆, 刘开政, 邓永强. 口腔钛种植体成骨性能的研究进展[J]. 中华口腔医学研究杂志(电子版), 2024, 18(03): 200-205.

Tian Chen, Xin Li, Kaizheng Liu, Yongqiang Deng. Research progress in bone osseointegration for implant dentistry[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(03): 200-205.

钛种植体因具有良好的骨整合能力，在口腔种植手术中得到了广泛的发展和应用。然而，钛种植体的骨整合能力受到表面特性、宿主状态和手术操作等多种因素的影响，可能导致种植体周围炎、无菌性松动等术后并发症。这给口腔种植手术的可靠性和稳定性带来了挑战。为了解决这一问题，目前的主要策略是深入研究骨整合的生物学机制，并开发具有动态响应功能的表面改性方法。因此，本文总结了骨-钛种植体界面的交互作用方式和钛种植体表面改性方法的最新进展，为进一步推动口腔种植手术发展和维护患者身心健康做出展望。

关键词: 钛种植体, 骨整合, 骨免疫调节, 表面改性

Titanium implants have been widely developed and utilized in oral implant surgery due to their excellent osseointegration capabilities. However, the osseointegration ability of titanium implants is influenced by various factors such as surface properties, host status, and surgical procedures, which may lead to postoperative complications such as peri-implantitis and aseptic loosening. This poses challenges to the reliability and stability of oral implant surgery. To solve this problem, the current main strategy is to deeply investigate the biological mechanisms of osseointegration and develop surface modification methods with dynamic responsive functions. Therefore, this paper summarized the interaction modes between bone and titanium implant interfaces and the latest advances in surface modification methods for titanium implants, providing prospects for further promoting the development of oral implant surgery and maintaining the physical and mental health of patients.

Key words: Titanium implants, Osseointegration, Osteoimmunomodulation, Surface modification
图1 骨整合相关生物事件序列的示意图
[1]
Buser D，Sennerby L，de Bruyn H. Modern implant dentistry based on osseointegration：50 years of progress，current trends and open questions[J]. Periodontology 2000，2017，73（1）：7-21. DOI：10.1111/prd.12185.
[2]
Albrektsson T，Brånemark PI，Hansson HA，et al. Osseointegrated titanium implants. Requirements for ensuring a long-lasting，direct bone-to-implant anchorage in man[J]. Acta Orthop Scand，1981，52（2）：155-170. DOI：10.3109/17453678108991776.
[3]
Shah FA，Thomsen P，Palmquist A. Osseointegration and current interpretations of the bone-implant interface[J]. Acta Biomaterialia，2019，84：1-15. DOI：10.1016/j.actbio.2018.11.018.
[4]
Guglielmotti MB，Olmedo DG，Cabrini RL. Research on implants and osseointegration[J]. Periodontol 2000，2019，79（1）：178-189. DOI：10.1111/prd.12254.
[5]
Williams DF. Biocompatibility pathways：Biomaterials-Induced sterile inflammation，mechanotransduction，and principles of biocompatibility control[J]. ACS Biomater Sci Eng，2017，3（1）：2-35. DOI：10.1021/acsbiomaterials.6b00607.
[6]
Williams DF. On the mechanisms of biocompatibility[J]. Biomaterials，2008，29（20）：2941-2953. DOI：10.1016/j.biomaterials.2008.04.023.
[7]
Jiang P，Zhang Y，Hu R，et al. Advanced surface engineering of titanium materials for biomedical applications：From static modification to dynamic responsive regulation[J]. Bioact Mater，2023，27：15-57. DOI：10.1016/j.bioactmat.2023.03.006.
[8]
Li JJ，Zreiqat H. Tissue response to biomaterials[M]//Narayan R. Encyclopedia of biomedical engineering. Elsevier Inc，2019：270-277. DOI：10.1016/B978-0-12-801238-3.99880-5.
[9]
Esposito M，Ardebili Y，Worthington HV. WITHDRAWN：Interventions for replacing missing teeth：Different types of dental implants[J]. Cochrane Database Syst Rev，2019，10（10）：CD003815. DOI：10.1002/14651858.CD003815.pub5.
[10]
Williams DF. Biocompatibility pathways and mechanisms for bioactive materials：The bioactivity zone[J]. Bioact Mater，2022，10：306-322. DOI：10.1016/j.bioactmat.2021.08.014.
[11]
Reis RL. 2nd Consensus conference on definitions on biomaterials science[J]. J Tissue Eng Regen Med，2020，14（4）：561-562. DOI：10.1002/term.3016.
[12]
Boudin E，van Hul W. Mechanisms in endocrinology：Genetics of human bone formation[J]. Eur J Endocrinol，2017，177（2）：R69-R83. DOI：10.1530/EJE-16-0990.
[13]
Schwarz F，Derks J，Monje A，et al. Peri-implantitis[J]. J Periodontol，2018，89（Suppl 1）：S267-S290. DOI：10.1002/jper.16-0350.
[14]
Insua A，Galindo-Moreno P，Miron RJ，et al. Emerging factors affecting peri-implant bone metabolism[J]. Periodontol 2000，2023. DOI：10.1111/prd.12532.
[15]
Alghamdi HS，Jansen JA. The development and future of dental implants[J]. Dent Mater J，2020，39（2）：167-172. DOI：10.4012/dmj.2019-140.
[16]
Chen X，Giles J，Yao Y，et al. The path to healthy ageing in China：A Peking University-Lancet Commission[J]. Lancet，2022，400（10367）：1967-2006. DOI：10.1016/s0140-6736(22)01546-x.
[17]
Darby I. Risk factors for periodontitis & peri-implantitis[J]. Periodontol 2000，2022，90（1）：9-12. DOI：10.1111/prd.12447.
[18]
Guo J，Yao H，Li X，et al. Advanced Hydrogel systems for mandibular reconstruction[J]. Bioact Mater，2023，21：175-193. DOI：10.1016/j.bioactmat.2022.08.001.
[19]
Leucht P，Kim JB，Amasha R，et al. Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration[J]. Development，2008，135（17）：2845-2854. DOI：10.1242/dev.023788.
[20]
Achilleos A，Trainor PA. Neural crest stem cells：Discovery，properties and potential for therapy[J]. Cell Res，2012，22（2）：288-304. DOI：10.1038/cr.2012.11.
[21]
Palmquist A，Omar OM，Esposito M，et al. Titanium oral implants：Surface characteristics，interface biology and clinical outcome[J]. J R Soc Interface，2010，7（Suppl 5）：S515-S527. DOI：10.1098/rsif.2010.0118.focus.
[22]
Colnot C，Romero DM，Huang S，et al. Molecular analysis of healing at a bone-implant interface[J]. J Dent Res，2007，86（9）：862-867. DOI：10.1177/154405910708600911.
[23]
Pandey C，Rokaya D，Bhattarai BP. Contemporary concepts in osseointegration of dental implants：A review[J]. Biomed Res Int，2022：6170452. DOI：10.1155/2022/6170452.
[24]
Wu B，Tang Y，Wang K，et al. Nanostructured titanium implant surface facilitating osseointegration from protein adsorption to osteogenesis：The example of TiO2 NTAs[J]. Int J Nanomedicine，2022，17：1865-1879. DOI：10.2147/ijn.S362720.
[25]
Lin DJ，Fuh LJ，Chen WC. Nano-morphology，crystallinity and surface potential of anatase on micro-arc oxidized titanium affect its protein adsorption，cell proliferation and cell differentiation [J]. Mater Sci Eng C Mater Biol Appl，2020，107：110204. DOI：10.1016/j.msec.2019.110204.
[26]
Visalakshan RM，MacGregor MN，Sasidharan S，et al. Biomaterial surface hydrophobicity-mediated serum protein adsorption and immune responses[J]. ACS Appl Mater Interfaces，2019，11（31）：27615-27623. DOI：10.1021/acsami.9b09900.
[27]
Bai L，Zhao Y，Chen P，et al. Targeting early healing phase with titania nanotube arrays on tunable diameters to accelerate bone regeneration and osseointegration[J]. Small，2021，17（4）：e2006287. DOI：10.1002/smll.202006287.
[28]
Zhang L，Liao X，Fok A，et al. Effect of crystalline phase changes in titania（TiO2）nanotube coatings on platelet adhesion and activation[J]. Mater Sci Eng C Mater Biol Appl，2018，82：91-101. DOI：10.1016/j.msec.2017.08.024.
[29]
Chen Z，Klein T，Murray RZ，et al. Osteoimmunomodulation for the development of advanced bone biomaterials[J]. Materials Today，2016，19（6）：304-321. DOI：10.1016/j.mattod.2015.11.004.
[30]
Wang X，Li Y，Feng Y，et al. The role of macrophages in osseointegration of dental implants：An experimental study in vivo[J]. J Biomed Mater Res A，2020，108（11）：2206-2216. DOI：10.1002/jbm.a.36978.
[31]
Davies LC，Jenkins SJ，Allen JE，et al. Tissue-resident macrophages[J]. Nat Immunol，2013，14（10）：986-995. DOI：10.1038/ni.2705.
[32]
Williams DF. The plasticity of biocompatibility[J]. Biomaterials，2023，296：122077. DOI：10.1016/j.biomaterials.2023.122077.
[33]
杨帮成，周学东，于海洋，等.钛种植体表面改性方法[J].华西口腔医学杂志，2019，37（2）：124-129. DOI：10.7518/hxkq.2019.02.002.
[34]
Barth KA，Waterfield JD，Brunette DM. The effect of surface roughness on RAW 264.7 macrophage phenotype[J]. J Biomed Mater Res A，2013，101（9）：2679-2688. DOI：10.1002/jbm.a.34562.
[35]
Qi H，Shi M，Ni Y，et al. Size-confined effects of nanostructures on fibronectin-induced macrophage inflammation on titanium implants[J]. Adv Healthc Mater，2021，10（20）：e2100994. DOI：10.1002/adhm.202100994.
[36]
He Y，Luo J，Zhang Y，et al. The unique regulation of implant surface nanostructure on macrophages M1 polarization[J]. Mater Sci Eng C Mater Biol Appl，2020，106：110221. DOI：10.1016/j.msec.2019.110221.
[37]
Hotchkiss KM，Clark NM，Olivares-Navarrete R. Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations[J]. Biomaterials，2018，182：202-215. DOI：10.1016/j.biomaterials.2018.08.029.
[38]
车振家，朱正清，朱礼伟，等.钛植入物表面生物化学改性对骨整合的影响[J].中国组织工程研究，2022，26（16）：2576-2583.
[39]
Fernandes KR，Zhang Y，Magri AMP，et al. Biomaterial property effects on platelets and macrophages：An in vitro study [J]. ACS Biomater Sci Eng，2017，3（12）：3318-3327. DOI：10.1021/acsbiomaterials.7b00679.
[40]
Quan H，Kim Y，Park HC，et al. Effects of phosphatidylserine-containing supported lipid bilayers on the polarization of macrophages[J]. J Biomed Mater Res A，2018，106（10）：2625-2633. DOI：10.1002/jbm.a.36454.
[41]
Qiao W，Wong KHM，Shen J，et al. TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration[J]. Nat Commun，2021，12（1）：2885. DOI：10.1038/s41467-021-23005-2.
[42]
Sun AR，Sun Q，Wang Y，et al. Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation[J]. Biomater Res，2023，27（1）：21. DOI：10.1186/s40824-023-00361-2.
[43]
Shirazi S，Ravindran S，Cooper LF. Topography-mediated immunomodulation in osseointegration；Ally or Enemy[J]. Biomaterials，2022，291：121903. DOI：10.1016/j.biomaterials.2022.121903.
[44]
Bosshardt DD，Chappuis V，Buser D. Osseointegration of titanium，titanium alloy and zirconia dental implants：current knowledge and open questions[J]. Periodontol 2000，2017，73（1）：22-40. DOI：10.1111/prd.12179.
[45]
Kim WJ，Cho YD，Ku Y，et al. The worldwide patent landscape of dental implant technology[J]. Biomater Res，2022，26（1）：59. DOI：10.1186/s40824-022-00307-0.
[46]
Wang L，He H，Yang X，et al. Bimetallic ions regulated PEEK of bone implantation for antibacterial and osteogenic activities [J]. Materials Today Advances，2021，12：100162. DOI：10.1016/j.mtadv.2021.100162.
[47]
Xiao R，Zhou G，Wen Y，et al. Recent advances on stimuli-responsive biopolymer-based nanocomposites for drug delivery [J]. Composites Part B：Engineering，2023，266：111018. DOI：10.1016/j.compositesb.2023.111018.
[48]
Guo Q，Zhou C，Ma Z，et al. Fundamentals of TiO2 Photocatalysis：Concepts，Mechanisms，and Challenges[J]. Adv Mater，2019，31（50）：e1901997. DOI：10.1002/adma.201901997.
[49]
Fu J，Liu X，Tan L，et al. Photoelectric-responsive extracellular matrix for bone engineering[J]. ACS Nano，2019，13（11）：13581-13594. DOI：10.1021/acsnano.9b08115.
[50]
Zhao J，Xu J，Jian X，et al. NIR light-driven photocatalysis on amphiphilic TiO2 nanotubes for controllable drug release[J]. ACS Appl Mater Interfaces，2020，12（20）：23606-23616. DOI：10.1021/acsami.0c04260.
[51]
Yu YL，Wu JJ，Lin CC，et al. Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration[J]. Mil Med Res，2023，10（1）：21. DOI：10.1186/s40779-023-00454-y.
[52]
Uzair U，Benza D，Behrend CJ，et al. Noninvasively imaging pH at the surface of implanted orthopedic devices with X-ray excited luminescence chemical imaging[J]. ACS Sens，2019，4（9）：2367-2374. DOI：10.1021/acssensors.9b00962.
[53]
Mazare A，Park J，Simons S，et al. Black TiO2 nanotubes：Efficient electrodes for triggering electric field-induced stimulation of stem cell growth[J]. Acta Biomater，2019，97：681-688. DOI：10.1016/j.actbio.2019.08.021.
[54]
Wu C，He X，Zhu Y，et al. Electrochemical deposition of Ppy/Dex/ECM coatings and their regulation on cellular responses through electrical controlled drug release[J]. Colloids Surf B Biointerfaces，2023，222：113016. DOI：10.1016/j.colsurfb.2022.113016.
[55]
Liu W，Li X，Jiao Y，et al. Biological effects of a three-dimensionally printed Ti6Al4V scaffold coated with piezoelectric BaTiO3 nanoparticles on bone formation[J]. ACS Appl Mater Interfaces，2020，12（46）：51885-51903. DOI：10.1021/acsami.0c10957.
[56]
Wu H，Dong H，Tang Z，et al. Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promotes anti-inflammatory polarization of macrophages and bone repair via MAPK/JNK inhibition and OXPHOS activation[J]. Biomaterials，2023，293：121990. DOI：10.1016/j.biomaterials.2022.121990.
[57]
Seetharaman S，Etienne-Manneville S. Cytoskeletal crosstalk in cell migration[J]. Trends Cell Biol，2020，30（9）：720-735. DOI：10.1016/j.tcb.2020.06.004.
[58]
Chen J，Li J，Hu F，et al. Effect of microarc oxidation-treated Ti6Al4V scaffold following low-intensity pulsed ultrasound stimulation on osteogenic cells in vitro[J]. ACS Biomater Sci Eng，2019，5（2）：572-581. DOI：10.1021/acsbiomaterials.8b01000.
[59]
Lin S，Li J，Shao J，et al. Anisotropic magneto-mechanical stimulation on collagen coatings to accelerate osteogenesis[J]. Colloids Surf B Biointerfaces，2022，210：112227. DOI：10.1016/j.colsurfb.2021.112227.
[60]
Lv X，Zhang J，Yang D，et al. Recent advances in pH-responsive nanomaterials for anti-infective therapy[J]. J Mater Chem B，2020，8（47）：10700-10711. DOI：10.1039/d0tb02177f.
[61]
Zhang L，Yang Y，Xiong YH，et al. Infection-responsive long-term antibacterial bone plates for open fracture therapy[J]. Bioact Mater，2023，25：1-12. DOI：10.1016/j.bioactmat.2023.01.002.
[62]
Zhou W，Bai T，Wang L，et al. Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration[J]. Bioact Mater，2023，20：64-80. DOI：10.1016/j.bioactmat.2022.05.015.
[63]
Yu Y，Ran Q，Shen X，et al. Enzyme responsive titanium substrates with antibacterial property and osteo/angio-genic differentiation potentials[J]. Colloids Surf B Biointerfaces，2020，185：110592. DOI：10.1016/j.colsurfb.2019.110592.
[64]
Zhang Y，Hu K，Xing X，et al. Smart titanium coating composed of antibiotic conjugated peptides as an infection-responsive antibacterial agent[J]. Macromol Biosci，2021，21（1）：e2000194. DOI：10.1002/mabi.202000194.
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