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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 200 -205. doi: 10.3877/cma.j.issn.1674-1366.2024.03.010

综述

口腔钛种植体成骨性能的研究进展
陈天1, 李歆2, 刘开政3, 邓永强4,†()   
  1. 1. 深圳大学总医院口腔科，深圳　518055；杭州师范大学口腔医学院，杭州　311121
    2. 深圳大学总医院口腔科，深圳　518055；深圳大学口腔医学研究所，深圳　518055
    3. 中国科学院深圳先进技术研究院人体组织与器官退行性研究中心，深圳　518055
    4. 深圳大学总医院口腔科，深圳　518055；杭州师范大学口腔医学院，杭州　311121；深圳大学口腔医学研究所，深圳　518055
  • 收稿日期:2024-02-24 出版日期:2024-06-01
  • 通信作者: 邓永强

Research progress in bone osseointegration for implant dentistry

Tian Chen1, Xin Li2, Kaizheng Liu3, Yongqiang Deng4,†()   

  1. 1. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; Institute of Stomatological Research, Shenzhen University, Shenzhen 518055, China
    2. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; School of Stomatology, Hangzhou Normal University, Hangzhou 311121, China
    3. Research Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    4. Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, China; School of Stomatology, Hangzhou Normal University, Hangzhou 311121, China; Institute of Stomatological Research, Shenzhen University, Shenzhen 518055, China
  • Received:2024-02-24 Published:2024-06-01
  • Corresponding author: Yongqiang Deng
  • Supported by:
    National Natural Science Foundation of China(81901058); Science Technology and Innovation Committee of Shenzhen Municipality(20220810163811002)
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陈天, 李歆, 刘开政, 邓永强. 口腔钛种植体成骨性能的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(03): 200-205.

Tian Chen, Xin Li, Kaizheng Liu, Yongqiang Deng. Research progress in bone osseointegration for implant dentistry[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(03): 200-205.

钛种植体因具有良好的骨整合能力，在口腔种植手术中得到了广泛的发展和应用。然而，钛种植体的骨整合能力受到表面特性、宿主状态和手术操作等多种因素的影响，可能导致种植体周围炎、无菌性松动等术后并发症。这给口腔种植手术的可靠性和稳定性带来了挑战。为了解决这一问题，目前的主要策略是深入研究骨整合的生物学机制，并开发具有动态响应功能的表面改性方法。因此，本文总结了骨-钛种植体界面的交互作用方式和钛种植体表面改性方法的最新进展，为进一步推动口腔种植手术发展和维护患者身心健康做出展望。

关键词: 钛种植体, 骨整合, 骨免疫调节, 表面改性

Titanium implants have been widely developed and utilized in oral implant surgery due to their excellent osseointegration capabilities. However, the osseointegration ability of titanium implants is influenced by various factors such as surface properties, host status, and surgical procedures, which may lead to postoperative complications such as peri-implantitis and aseptic loosening. This poses challenges to the reliability and stability of oral implant surgery. To solve this problem, the current main strategy is to deeply investigate the biological mechanisms of osseointegration and develop surface modification methods with dynamic responsive functions. Therefore, this paper summarized the interaction modes between bone and titanium implant interfaces and the latest advances in surface modification methods for titanium implants, providing prospects for further promoting the development of oral implant surgery and maintaining the physical and mental health of patients.

Key words: Titanium implants, Osseointegration, Osteoimmunomodulation, Surface modification
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