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中华口腔医学研究杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 130 -136. doi: 10.3877/cma.j.issn.1674-1366.2022.02.011

综述

半导体激光在牙周病领域的应用进展
周明莉1, 高琪1,†(), 王芳1   
  1. 1. 河北医科大学第二医院口腔科，石家庄　050000
  • 收稿日期:2021-12-25 出版日期:2022-04-01
  • 通信作者: 高琪

Research progress of semiconductor laser in periodontal disease

Mingli Zhou1, Qi Gao1,†(), Fang Wang1   

  1. 1. Department of Stomatology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2021-12-25 Published:2022-04-01
  • Corresponding author: Qi Gao
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引用本文：

周明莉, 高琪, 王芳. 半导体激光在牙周病领域的应用进展[J]. 中华口腔医学研究杂志(电子版), 2022, 16(02): 130-136.

Mingli Zhou, Qi Gao, Fang Wang. Research progress of semiconductor laser in periodontal disease[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(02): 130-136.

牙周炎是指破坏牙龈、牙周膜、牙骨质和牙槽骨等牙周附着组织的常见慢性感染性疾病，是成年人牙齿丧失的主要原因之一，严重影响患者身心健康。传统的龈下刮治和根面平整（SRP）是临床应用较多且有效的治疗方法，但同时也具有局限性，随着现代诊疗技术和激光水平的发展，半导体激光开始应用于牙周炎的治疗，在牙周非手术治疗和手术治疗方面具有突出的表现，本文将对半导体激光在牙周炎治疗方面的研究现状作一综述。

关键词: 半导体激光, 牙周炎, 牙周指标, 微生物, 炎症因子, 牙周手术

Periodontitis is a common chronic infectious disease that damages gingiva, periodontal ligament, cementum, alveolar bone and other periodontal attachment tissues. It is one of the main causes of tooth loss for adults, which seriously affects patients′ physical and mental health. It is believed that traditional scaling and root planning (SRP) are widely applied in periodontal treatment with limitations. With the development of new technologies assisted in modern diagnosis and treatment, Semiconductor Laser has been proved to be very efficient in non-surgical and surgical periodontal treatment. This paper reviews the research results concerning semiconductor laser in periodontitis treatment in recent years.

Key words: Semiconductor laser, Periodontitis, Periodontal index, Microorganism, Inflammatory factors, Periodontal surgery
[1]
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global，regional，and national incidence，prevalence，and years lived with disability for 354 diseases and injuries for 195 countries and territories，1990—2017：A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet，2018，392（10159）：1789-1858. DOI：10.1016/S0140-6736(18)32279-7.
[2]
John MT，Michalowicz BS，Kotsakis GA，et al. Network meta-analysis of studies included in the Clinical Practice Guideline on the nonsurgical treatment of chronic periodontitis[J]. J Clin Periodontol，2017，44（6）：603-611. DOI：10.1111/jcpe.12726.
[3]
Jia L，Jia J，Xie M，et al. Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis：A network meta-analysis of randomized controlled clinical trials[J]. Lasers Med Sci，2020，35（2）：473-485. DOI：10.1007/s10103-019-02875-5.
[4]
Yadwad KJ，Veena HR，Patil SR，et al. Diode laser therapy in the management of chronic periodontitis：A clinico-microbiological study[J]. Interv Med Appl Sci，2017，9（4）：191-198. DOI：10.1556/1646.9.2017.38.
[5]
Aykol G，Baser U，Maden I，et al. The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment[J]. J Periodontol，2011，82（3）：481-488. DOI：10.1902/jop.2010.100195.
[6]
Cobb CM，Low SB，Coluzzi DJ. Lasers and the treatment of chronic periodontitis[J]. Dent Clin North Am，2010，54（1）：35-53. DOI：10.1016/j.cden.2009.08.007.
[7]
陶玉飞，郭凤芹.半导体激光辅助重度慢性牙周炎牙周非手术治疗的临床研究[J].口腔医学研究，2018，34（10）：1085-1088. DOI：10.13701/j.cnki.kqyxyj.2018.10.013.
[8]
Chambrone L，Ramos UD，Reynolds MA. Infrared lasers for the treatment of moderate to severe periodontitis：An American Academy of Periodontology best evidence review[J]. J Periodontol，2018，89（7）：743-765. DOI：10.1902/jop.2017.160504.
[9]
Gutiérrez-Corrales A，Rizcala-Orlando Y，Montero-Miralles P，et al. Comparison of diode laser—Oral tissue interaction to different wavelengths. In vitro study of porcine periodontal pockets and oral mucosa[J]. Med Oral Patol Oral Cir Bucal，2020，25（2）：e224-e232. DOI：10.4317/medoral.23317.
[10]
Parker S. Lasers and soft tissue：Periodontal therapy[J]. Br Dent J，2007，202（6）：309-315. DOI：10.1038/bdj.2007.224.
[11]
Theodoro LH，Marcantonio RAC，Wainwright M，et al. LASER in periodontal treatment：Is it an effective treatment or science fiction？[J]. Braz Oral Res，2021，35（Supp 2）：e99. DOI：10.1590/1807-3107bor-2021.vol35.0099.
[12]
Dukić W，Bago I，Aurer A，et al. Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment：A randomized clinical study[J]. J Periodontol，2013，84（8）：1111-1117. DOI：10.1902/jop.2012.110708.
[13]
张丽娟，石晶，郭杰华，等.半导体激光辅助治疗慢性牙周炎的临床效果[J].实用口腔医学杂志，2018，34（3）：404-406. DOI：10.3969/j.issn.1001-3733.2018.03.026.
[14]
Ishikawa I，Aoki A，Takasaki AA，et al. Application of lasers in periodontics：True innovation or myth？[J]. Periodontol 2000，2009，50：90-126. DOI：10.1111/j.1600-0757.2008.00283.x.
[15]
Barbosa FI，Araújo PV，Machado LJC，et al. Effect of photodynamic therapy as an adjuvant to non-surgical periodontal therapy：Periodontal and metabolic evaluation in patients with type 2 diabetes mellitus[J]. Photodiagnosis Photodyn Ther，2018，22：245-250. DOI：10.1016/j.pdpdt.2018.04.013.
[16]
Franco T，Dos SA，Canabarro A. The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets：A systematic review[J]. Lasers Med Sci，2019，34（5）：855-863. DOI：10.1007/s10103-018-02703-2.
[17]
Matarese G，Ramaglia L，Cicciù M，et al. The effects of diode laser therapy as an adjunct to scaling and root planing in the treatment of aggressive periodontitis：A 1-year randomized controlled clinical trial[J]. Photomed Laser Surg，2017，35（12）：702-709. DOI：10.1089/pho.2017.4288.
[18]
Goh EX，Tan KS，Chan YH，et al. Effects of root debridement and adjunctive photodynamic therapy in residual pockets of patients on supportive periodontal therapy：A randomized split-mouth trial[J]. Photodiagnosis Photodyn Ther，2017，18：342-348. DOI：10.1016/j.pdpdt.2017.03.017.
[19]
李淑华，周永敏，丁红忠.老年慢性牙周炎患者半导体激光治疗的有效性及对患者PD CAL SBI的影响[J].河北医学，2021，27（8）：1308-1312. DOI：10.3969/j.issn.1006-6233.2021.08.016.
[20]
申林，于淑玲，赵娜，等.半导体激光辅助治疗慢性牙周炎的疗效及其对牙周学指标的影响研究[J].中国医学装备，2021，18（6）：116-119. DOI：10.3969/J.ISSN.1672-8270.2021.06.030.
[21]
Cobb CM. Commentary：Is there clinical benefit from using a diode or neodymium：Yttrium-Aluminum-Garnet laser in the treatment of periodontitis？[J]. J Periodontol，2016，87（10）：1117-1131. DOI：10.1902/jop.2016.160134.
[22]
Mombelli A. Microbial colonization of the periodontal pocket and its significance for periodontal therapy[J]. Periodontol 2000，2018，76（1）：85-96. DOI：10.1111/prd.12147.
[23]
Fischer RG，Junior LR，Retamal-Valdes B，et al. Periodontal disease and its impact on general health in Latin America. Section V：Treatment of periodontitis[J]. Braz Oral Res，2020，34（supp1 1）：e026. DOI：10.1590/1807-3107bor-2020.vol34.0026.
[24]
Mahalakshmi MR，Leela RP，Yadalam PK，et al. Estimation of red-complex bacteria in diode laser treated chronic periodontitis patients：A clinical and microbiological study[J]. J Pharm Bioallied Sci，2020，12（Suppl 1）：S140-S145. DOI：10.4103/jpbs.JPBS_45_20.
[25]
Moritz A，Schoop U，Goharkhay K，et al. Treatment of periodontal pockets with a diode laser[J]. Lasers Surg Med，1998，22（5）：302-311. DOI：10.1002/(sici)1096-9101(1998)22:5<302::aid-lsm7>3.0.co;2-t.
[26]
Slots J，Genco RJ. Black-pigmented Bacteroides species，Capnocytophaga species，and Actinobacillus actinomycetemcomitans in human periodontal disease：Virulence factors in colonization，survival，and tissue destruction[J]. J Dent Res，1984，63（3）：412-421. DOI：10.1177/00220345840630031101.
[27]
Meseli SE，Kuru B，Kuru L. Effects of 810-nanometer diode laser as an adjunct to mechanical periodontal treatment on clinical periodontal parameters and gingival crevicular fluid volume of residual periodontal pockets[J]. Niger J Clin Pract，2017，20（4）：427-432. DOI：10.4103/1119-3077.181382.
[28]
Chen M，Cai W，Zhao S，et al. Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis：A systematic review and meta-analysis[J]. J Clin Periodontol，2019，46（6）：608-622. DOI：10.1111/jcpe.13112.
[29]
Baima G，Corana M，Iaderosa G，et al. Metabolomics of gingival crevicular fluid to identify biomarkers for periodontitis：A systematic review with meta-analysis[J]. J Periodontal Res，2021，56（4）：633-645. DOI：10.1111/jre.12872.
[30]
Gursoy UK，Könönen E. Understanding the roles of gingival beta-defensins[J]. J Oral Microbiol，2012，4：15127. DOI：10.3402/jom.v4i0.15127.
[31]
Offenbacher S，Jiao Y，Kim SJ，et al. GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation[J]. Nat Commun，2018，9（1）：3686. DOI：10.1038/s41467-018-05940-9.
[32]
Loo WT，Wang M，Jin LJ，et al. Association of matrix metalloproteinase（MMP-1，MMP-3 and MMP-9）and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis[J]. Arch Oral Biol，2011，56（10）：1081-1090. DOI：10.1016/j.archoralbio.2011.03.011.
[33]
Saglam M，Kantarci A，Dundar N，et al. Clinical and biochemical effects of diode laser as an adjunct to nonsurgical treatment of chronic periodontitis：A randomized，controlled clinical trial[J]. Lasers Med Sci，2014，29（1）：37-46. DOI：10.1007/s10103-012-1230-0.
[34]
Giannopoulou C，Cappuyns I，Cancela J，et al. Effect of photodynamic therapy，diode laser，and deep scaling on cytokine and acute-phase protein levels in gingival crevicular fluid of residual periodontal pockets[J]. J Periodontol，2012，83（8）：1018-1027. DOI：10.1902/jop.2011.110281.
[35]
Caruso U，Nastri L，Piccolomini R，et al. Use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. A randomized controlled clinical trial[J]. New Microbiol，2008，31（4）：513-518.
[36]
Bozkurt SB，Hakki EE，Kayis SA，et al. Biostimulation with diode laser positively regulates cementoblast functions，in vitro[J]. Lasers Med Sci，2017，32（4）：911-919. DOI：10.1007/s10103-017-2192-z.
[37]
Pai BSJ，Krishnan NR，Walveker A，et al. Comparative evaluation of sclerostin levels in gingival crevicular fluid in the treatment of chronic periodontitis patients using diode laser as an adjunct to scaling and root planing：A clinico-biochemical study[J]. Contemp Clin Dent，2021，12（3）：276-281. DOI：10.4103/ccd.ccd_19_20.
[38]
Pawelczyk-Madalinska M，Benedicenti S，S？l？gean T，et al. Impact of adjunctive diode laser application to non-surgical periodontal therapy on clinical，microbiological and immunological outcomes in management of chronic periodontitis：A systematic review of human randomized controlled clinical trials[J]. J Inflamm Res，2021，14：2515-2545. DOI：10.2147/JIR.S304946.
[39]
宦泓，梅幼敏，曹盈，等.双波长激光应用于牙周手术的临床评价[J].南通大学学报（医学版），2018，38（4）：309-311. DOI：10.16424/j.cnki.cn32-1807/r.2018.04.025.
[40]
Khan F，Chopra R，Sharma N，et al. Comparative evaluation of the efficacy of diode laser as an adjunct to modified Widman flap surgery for the treatment of chronic periodontitis：A randomized split-mouth clinical trial[J]. J Indian Soc Periodontol，2021，25（3）：213-219. DOI：10.4103/jisp.jisp_252_20.
[41]
Karthikeyan J，Vijayalakshmi R，Mahendra J，et al. Diode laser as an adjunct to kirkland flap surgery：A randomized split-mouth clinical and microbiological study[J]. Photobiomodul Photomed Laser Surg，2019，37（2）：99-109. DOI：10.1089/photob.2018.4519.
[42]
Dalvi S，Khetal N，Ansari S，et al. Utilization of 810 nm diode laser treatment in periodontitis as an alternative to surgical debridement approach[J]. Photochem Photobiol，2021，97（3）：566-573. DOI：10.1111/php.13417.
[43]
Heidari M，Paknejad M，Jamali R，et al. Effect of laser photobiomodulation on wound healing and postoperative pain following free gingival graft：A split-mouth triple-blind randomized controlled clinical trial[J]. J Photochem Photobiol B，2017，172：109-114. DOI：10.1016/j.jphotobiol.2017.05.022.
[44]
Lobo TM，Pol DG. Evaluation of the use of a 940 nm diode laser as an adjunct in flap surgery for treatment of chronic periodontitis[J]. J Indian Soc Periodontol，2015，19（1）：43-48. DOI：10.4103/0972-124X.145808.
[45]
Ozcelik O，Seydaoglu G，Haytac CM. Diode laser for harvesting de-epithelialized palatal graft in the treatment of gingival recession defects：A randomized clinical trial[J]. J Clin Periodontol，2016，43（1）：63-71. DOI：10.1111/jcpe.12487.
[46]
Dalvi SA，Hanna R，Gattani DR. Utilisation of antimicrobial photodynamic therapy as an adjunctive tool for open flap debridement in the management of chronic periodontitis：A randomized controlled clinical trial[J]. Photodiagnosis Photodyn Ther，2019，25：440-447. DOI：10.1016/j.pdpdt.2019.01.023.
[47]
Jonnalagadda BD，Gottumukkala S，Dwarakanath CD，et al. Effect of diode laser-assisted flap surgery on postoperative healing and clinical parameters：A randomized controlled clinical trial[J]. Contemp Clin Dent，2018，9（2）：205-212. DOI：10.4103/ccd.ccd_810_17.
[48]
Moro MG，de Carvalho VF，Godoy-Miranda BA，et al. Efficacy of antimicrobial photodynamic therapy（aPDT）for nonsurgical treatment of periodontal disease：A systematic review[J]. Lasers Med Sci，2021，36（8）：1573-1590. DOI：10.1007/s10103-020-03238-1.
[49]
Pourhajibagher M，Kazemian H，Chiniforush N，et al. Exploring different photosensitizers to optimize elimination of planktonic and biofilm forms of Enterococcus faecalis from infected root canal during antimicrobial photodynamic therapy[J]. Photodiagnosis Photodyn Ther，2018，24：206-211. DOI：10.1016/j.pdpdt.2018.09.014.
[50]
Derikvand N，Ghasemi SS，Safiaghdam H，et al. Antimicrobial photodynamic therapy with diode laser and methylene blue as an adjunct to scaling and root planning：A clinical trial[J]. Photodiagnosis Photodyn Ther，2020，31：101818. DOI：10.1016/j.pdpdt.2020.101818.
[51]
Mallineni S，Nagarakanti S，Gunupati S，et al. Clinical and microbiological effects of adjunctive photodynamic diode laser therapy in the treatment of chronic periodontitis：A randomized clinical trial[J]. J Dent Res Dent Clin Dent Prospects，2020，14（3）：191-197. DOI：10.34172/joddd.2020.030.
[52]
Xue D，Zhao Y. Clinical effectiveness of adjunctive antimicrobial photodynamic therapy for residual pockets during supportive periodontal therapy：A systematic review and meta-analysis[J]. Photodiagnosis Photodyn Ther，2017，17：127-133. DOI：10.1016/j.pdpdt.2016.11.011.
[53]
Monzavi A，Chinipardaz Z，Mousavi M，et al. Antimicrobial photodynamic therapy using diode laser activated indocyanine green as an adjunct in the treatment of chronic periodontitis：A randomized clinical trial[J]. Photodiagnosis Photodyn Ther，2016，14：93-97. DOI：10.1016/j.pdpdt.2016.02.007.
[54]
Katsikanis F，Strakas D，Vouros I. The application of antimicrobial photodynamic therapy（aPDT，670 nm）and diode laser（940 nm）as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease：A randomized controlled split-mouth clinical trial[J]. Clin Oral Investig，2020，24（5）：1821-1827. DOI：10.1007/s00784-019-03045-1.
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