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中华口腔医学研究杂志(电子版) ›› 2016, Vol. 10 ›› Issue (01) : 68 -71. doi: 10.3877/cma.j.issn.1674-1366.2016.06.013

所属专题: 口腔医学 文献

综述

Fibulin-7对牙齿发育调控作用的研究进展
欧阳宁鹃1, 代杰文1, 沈国芳1,()   
  1. 1. 200011 上海交通大学医学院附属第九人民医院口腔颅颌面科,上海市口腔医学重点实验室
  • 收稿日期:2015-10-10 出版日期:2016-02-01
  • 通信作者: 沈国芳
  • 基金资助:
    国家自然科学基金(81300842、81570947)

The progress on the regulation effect of Fibulin-7 in dental development

Ningjuan Ou-Yang1, Jiewen Dai1, Guofang Shen1,()   

  1. 1. Department of Crania & Oral Maxillofacial Science, Shanghai Ninth People′s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2015-10-10 Published:2016-02-01
  • Corresponding author: Guofang Shen
  • About author:
    Corresponding author: Shen Guofang, Email:
引用本文:

欧阳宁鹃, 代杰文, 沈国芳. Fibulin-7对牙齿发育调控作用的研究进展[J]. 中华口腔医学研究杂志(电子版), 2016, 10(01): 68-71.

Ningjuan Ou-Yang, Jiewen Dai, Guofang Shen. The progress on the regulation effect of Fibulin-7 in dental development[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2016, 10(01): 68-71.

Fibulin-7又称TM14,是Fibulin蛋白家族的成员之一,相对分子质量约为48 000,由440个氨基酸组成,最早通过牙胚cDNA基因芯片差异杂交方法鉴定得出。Fibulin蛋白家族广泛分布于基底膜、弹性纤维及疏松结缔组织中,与细胞外基质等组分相互作用,作用于器官发生及血管生成过程,在细胞外基质的形成及稳定中发挥了重要作用。Fibulin-7 mRNA在牙齿、毛囊及软骨中高表达;也在胎盘的海绵滋养层细胞及胚胎外组织中表达。在牙本质发育过程中,Fibulin-7与Fibulin-1、纤连蛋白及牙本质涎磷蛋白相互作用,对牙源性间充质细胞和成牙本质细胞具有黏附作用。Fibulin-7位于人染色体的2q13段,将其敲除后,在斑马鱼体内可引起先天性的心脏病及颅颌面发育的异常。本文就Fibulin-7对牙齿发育调控作用的研究进展作一综述。

Fibulin-7, known as TM14, has been identified as a new member of the Fibulin family proteins, and was firstly constructed and screened by differential hybridization using cDNA microarrays of dental germs. It is a 440-amino acid protein that has a calculated molecular weight of 48 000. As the Fibulin family proteins are expressed in basement membranes, elastic fibers and other matrices, they had been found in association with ECM and can play important parts in angiogenesis and organ development, which are involved in the process of forming and stabilizing the organization of ECM structures. Fibulin-7 mRNA is expressed not only in developing teeth, hair follicles and cartilage, but also in spongiotrophoblast cells of embryo, and extraembryonic tissues of the placenta. During odontoblast differentiation, Fibulin-7 interacts with Fibulin-1, fibronectin, and dentin sialophosphoprotein, and may serve as a cell adhesion molecule to anchor dental mesenchymal cells and odontoblasts in the dentin matrix. Fibulin-7 gene is located in human chromosome 2q13, and its deletion in zebrafish leads to congenital heart defects and craniofacial malformations. The purpose of this review is to summarize the effect of Fibulin-7 in dental development.

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