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中华口腔医学研究杂志(电子版)

中华口腔医学研究杂志(电子版) ›› 2018, Vol. 12 ›› Issue (04) : 255 -259. doi: 10.3877/cma.j.issn.1674-1366.2018.04.010

所属专题： 口腔医学； 文献；

综述

DKK1与牙齿发育和口腔疾病关系的研究进展
刘君杰1, 全宏志2, 张建3, 黄俊辉1,†()   
  1. 1. 410078　长沙，中南大学湘雅口腔医院病理科
    2. 410078　长沙，中南大学湘雅口腔医院口腔颌面外科
    3. 410078　长沙，湖南省紫百合义齿科技有限公司
  • 收稿日期:2018-03-28 出版日期:2018-08-01
  • 通信作者: 黄俊辉
  • 基金资助:
    湖南省科技计划(2017GK2265); 长沙市科技计划(Kq1701174)

Research progress on the relationship between DKK1 and dental development and oral diseases

Junjie Liu1, Hongzhi Quan2, Jian Zhang3, Junhui Huang1,†()   

  1. 1. Department of Pathology, Xiangya Stomatological Hopital, Central South University, Changsha 410078, China
    2. Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hopital, Central South University, Changsha 410078, China
    3. Z-Best Dental Science and Technology Company Limited, Changsha 410078, China
  • Received:2018-03-28 Published:2018-08-01
  • Corresponding author: Junhui Huang
  • About author:
    Corresponding author: Huang Junhui, Email:
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刘君杰, 全宏志, 张建, 黄俊辉. DKK1与牙齿发育和口腔疾病关系的研究进展[J]. 中华口腔医学研究杂志(电子版), 2018, 12(04): 255-259.

Junjie Liu, Hongzhi Quan, Jian Zhang, Junhui Huang. Research progress on the relationship between DKK1 and dental development and oral diseases[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2018, 12(04): 255-259.

Dickkopf家族（DKK）是进化中高度保守的古老体系，通过抑制Wnt通路的信号传导来发挥调节作用。DKK1作为DKK家族的重要成员具有广泛的生物学功能，可以通过调节细胞生长、迁移、分化来控制机体发育和疾病发展，在胚胎发育和肿瘤形成等方面研究较为成熟。随着近年来人们对口腔健康的重视和一些口腔疾病发病率逐年上涨，学者们对疾病的分子机制领域研究逐渐深入，DKK1通过调节Wnt通路这一重要机制在口腔医学领域也逐渐得到重视，并被认为是一个潜在的肿瘤治疗靶点。本文通过综述近年来国内外学者对DKK1在牙齿发育和口腔的常见疾病如口腔肿瘤、口腔黏膜下纤维化等方面的研究成果，分析其中可能的分子机制，为学者们未来进一步研究牙齿形态发育的精密调控机制和口腔疾病的防治提供理论参考与思路。

关键词: 牙齿发育, 口腔疾病, Dickkopf家族

The Dickkopf family (DKK) is a highly conserved ancient system during evolution, which has effects of regulation on inhibiting the signal transduction of the Wnt pathway. As a key member of the DKK family, DKK1 has a wide range of biological functions. It controls the growth and the progress of disease through regulating cell proliferation, migration and differentiation. There were wide range of studies on the embryonic development and tumorigenesis. With an increasing awareness of the importance of oral health and an increase in the incidence of some oral diseases, the molecular mechanisms of diseases have been investigated gradually. The fact that DKK1 regulates Wnt pathway has gradually gained attention in oral medicine, and it is thought to be a potential cancer treatment target. In recent years, scholars have discovered that DKK1 attracts attention by regulating cell growth, migration, and differentiation to affect the development of oral organs and the occurrence of oral diseases. In this paper, we reviewed the recent studies on the effects of DKK1 on tooth development and common oral diseases such as oral tumor and oral submucous fibrosis, and also analyzed the possible molecular mechanism. This review would provide a theoretical basis for the further investigation of the regulatory mechanism of tooth development and DKK1-targeting therapeutic strategies for oral diseases.

Key words: Tooth, developmental, Mouth diseases, Dickkopf family
图1 没有Wnt通路激活的情况下，β-catenin与APC、Axin形成的复合物被CKI、GSK3β磷酸化，进而被β-Trcp泛素化，最后降解
图2 在Wnt信号分子激活的情况下，Dsh蛋白激活，抑制AXIN/APC/GSK3β/CKI复合物形成，使β-catenin游离出来，进入细胞核并激活下游信号因子，影响靶基因的表达
图3 DKK1能与LRP6特异性结合或者通过Kremen受体以胞吞的方式降解LRP6，阻断Wnt信号通路的传导，最终β-catenin降解
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