目的

观察脉管畸形神经丝（neuofilament，NF）的表达，探讨感觉神经分布与脉管畸形中脉管扩张的关系。

方法

脉管畸形病例来自术后，选取107 例病变行免疫组织化学SP 法，NF单抗检测脉管畸形组织中感觉神经的分布。

结果

脉管畸形无规则扩张的血管和淋巴管周围感觉神经分布较少，混合脉管畸形，静脉畸形和淋巴管畸形之间比较差异无显著性（P ＞0.05），其中混合脉管畸形各年龄段神经分布差异无显著性， 而微静脉畸形扩张血管周围NF 几乎无表达（P ＜0.01）。

结论

感觉神经分布减少可能与脉管畸形的形成有关。

Objective

To investigate the expression of neurofilament （NF）in the malformations of tongue，and relation between nerves distribution and ectatic vessels.

Methods

107 postoperative vascular malformation cases were chosen for this study. All samples were stained with anti-NF monoclonal antibody to detect the distribution of sensory nerves by immunohistochemistry （SP method）.

Results

In the vascular malformations， few NF was seen around the ectatic vessels. Among venous malformations， lymphatic malformations and mixed malformations， there was no significant difference between each two of them（P ＞0.05）. And among the different ages， there was no obvious change in the mixed vascular malformation. But the expression of NF was almost negative in the venule malformations （P ＜0.01）.

Conclusion

The formation of vascular malformations may be associated with the decrease of sensory nerves.