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中华口腔医学研究杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 279 -284. doi: 10.3877/cma.j.issn.1674-1366.2025.04.008

综述

牙周炎与上消化道肿瘤的相关性研究进展
钟汪积, 周婕妤, 赵蕾()   
  1. 口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科,成都 610041
  • 收稿日期:2025-04-16 出版日期:2025-08-01
  • 通信作者: 赵蕾

Research progress on the correlation between periodontitis and upper gastrointestinal tract cancers

Wangji Zhong, Jieyu Zhou, Lei Zhao()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2025-04-16 Published:2025-08-01
  • Corresponding author: Lei Zhao
  • Supported by:
    National Natural Science Foundation of China(81970944, 82301089)
引用本文:

钟汪积, 周婕妤, 赵蕾. 牙周炎与上消化道肿瘤的相关性研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(04): 279-284.

Wangji Zhong, Jieyu Zhou, Lei Zhao. Research progress on the correlation between periodontitis and upper gastrointestinal tract cancers[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(04): 279-284.

牙周炎是一种菌斑生物膜为始动因子的口腔慢性炎症性疾病,可导致牙周支持组织破坏,危害口腔健康并降低患者生活质量。口腔是消化道的门户,牙周致病微生物易随唾液吞咽转移至上消化道,口腔可能是消化道疾病的潜在源头。有研究表明,牙周炎与上消化道肿瘤(食管癌与胃癌)存在潜在相关性,但其因果联系及具体机制仍不明晰。本文就牙周炎与上消化道肿瘤的最新研究进展加以综述,以期为后续深入研究两种疾病之间的关联机制提供参考。

Periodontitis is an oral chronic inflammatory disease initiated by plaque biofilm, which can lead to the destruction of periodontal supporting tissues, compromise oral health, and decrease the quality of life of patients. As the gateway to the gastrointestinal tract, oral pathogens can easily be transferred to the upper gastrointestinal tract through saliva swallowing, suggesting that the oral cavity may be a potential source of gastrointestinal tract diseases. Recent studies have indicated a potential correlation between periodontitis and upper gastrointestinal cancers (esophageal and gastric cancers). However, the causal relationship and specific mechanisms remain unclear. This article reviews the latest research progress on the relationship between periodontitis and upper gastrointestinal cancers, aiming to provide a reference for further investigation into the mechanisms underlying the association between these two diseases.

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