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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 150 -155. doi: 10.3877/cma.j.issn.1674-1366.2024.03.002

青年编委专栏

根尖周病中程序性细胞死亡的研究进展
廖泽楷1, 梁爱琳1, 龚启梅1,()   
  1. 1. 中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广东省口腔疾病临床医学研究中心,广州 510055
  • 收稿日期:2024-01-29 出版日期:2024-06-01
  • 通信作者: 龚启梅

Research progress on programmed cell death in periapical periodontitis

Zekai Liao1, Ailin Liang1, Qimei Gong1,()   

  1. 1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangdong Provincial Clinical Research Center of Oral Diseases, Guangzhou 510055, China
  • Received:2024-01-29 Published:2024-06-01
  • Corresponding author: Qimei Gong
  • Supported by:
    National Natural Science Foundation of China(81870750); Basic and Applied Basic Research Foundation of Guangdong Province(2023A1515010722)
引用本文:

廖泽楷, 梁爱琳, 龚启梅. 根尖周病中程序性细胞死亡的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(03): 150-155.

Zekai Liao, Ailin Liang, Qimei Gong. Research progress on programmed cell death in periapical periodontitis[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(03): 150-155.

程序性细胞死亡(PCD)是由基因决定的细胞主动、有序的死亡方式,其与根尖周病的进展密切相关。目前在根尖周病灶中发现的PCD途径有细胞凋亡、自噬、坏死性凋亡、细胞焦亡和铁死亡等。这些途径能被内源性和外源性刺激激活,在维持机体稳态和炎症调节中发挥重要作用。本文针对各种PCD途径在根尖周病中的作用进行综述,以期探究根尖周病的发病机制和靶向调控分子,从而为防治根尖周病提供新思路。

Programmed cell death (PCD) is a genetically determined, active, and orderly way of cell death, closely associated with the progression of periapical diseases. Various PCD pathways have been identified in periapical lesions, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis. These pathways can be activated by both endogenous and exogenous stimuli, playing crucial roles in maintaining homeostasis and regulating inflammation. This article provided a comprehensive review of the roles of different PCD pathways in periapical diseases, aiming to explore the pathogenesis and target regulatory molecules of periapical diseases, thereby offering new insights into their prevention and treatment.

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