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中华口腔医学研究杂志(电子版) ›› 2017, Vol. 11 ›› Issue (01) : 31 -35. doi: 10.3877/cma.j.issn.1674-1366.2017.01.006

所属专题: 文献

临床研究

慢性牙周炎与脑卒中关系的Meta分析
吕宗凯1, 郑杨灿2,(), 杜胜男1, 杨映阳1, 冯辉1, 邓礼辉1   
  1. 1. 637000 南充市中心医院口腔科,川北医学院第二临床医学院
    2. 637000 南充市中心医院泌尿外科
  • 收稿日期:2016-08-07 出版日期:2017-02-01
  • 通信作者: 郑杨灿

Relationship between chronic periodontitis and stroke: a Meta analysis

Zongkai Lyu1, Yangcan Zheng2,(), Shengnan Du1, Yingyang Yang1, Hui Feng1, Lihui Deng1   

  1. 1. Department of Stomatology, Nan Chong Central Hospital, Second Clinical Medical College of CHUAN BEI Medical College, Nanchong 637000, China
    2. Department of Urology Surgery, Nan Chong Central Hospital, Second Clinical Medical College of CHUAN BEI Medical College, Nanchong 637000, China
  • Received:2016-08-07 Published:2017-02-01
  • Corresponding author: Yangcan Zheng
  • About author:
    Corresponding author: Zheng Yangcan, Email:
引用本文:

吕宗凯, 郑杨灿, 杜胜男, 杨映阳, 冯辉, 邓礼辉. 慢性牙周炎与脑卒中关系的Meta分析[J/OL]. 中华口腔医学研究杂志(电子版), 2017, 11(01): 31-35.

Zongkai Lyu, Yangcan Zheng, Shengnan Du, Yingyang Yang, Hui Feng, Lihui Deng. Relationship between chronic periodontitis and stroke: a Meta analysis[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2017, 11(01): 31-35.

目的

探究慢性牙周炎与脑卒中之间的病因学联系。

方法

电子检索CBM数据库(1978—2016年)、维普、CNKI、Medline(OVID,1950—2016年)和荷兰医学文摘(EMBASE,1984—2016年)、Cochrane图书馆临床随机对照试验库(CENTRAL,2016年第9期)等中英文期刊数据库并手检中文口腔期刊,收集有关慢性牙周炎与脑卒中相关性的文献。两位研究者独立进行文献筛选、质量评价和数据提取(牙周炎患病率、临床附着丧失量、菌斑指数和血清C反应蛋白)并用Revman 5.3.3软件进行Meta分析。

结果

最终纳入12篇文献(2篇中文、10篇英文),纳入研究对象2835例,其中脑卒中患者1396例。Meta分析结果显示,脑卒中患者牙周炎患病率明显高于对照组[OR= 2.89,95% CI=(2.00,4.17),P<0.001],脑卒中患者的牙周炎较对照组更为严重[OR= 1.25,95% CI= (0.50,2.00),P= 0.001]且其口腔卫生更差[OR= 0.32,95% CI=(0.11,0.54),P= 0.004],脑卒中患者血清炎症因子C反应蛋白水平明显升高[OR= 5.38,95% CI=(4.78,5.97),P<0.001]。

结论

慢性牙周炎与脑卒中之间可能存在一定的相关性。

Objective

To evaluate the etiology relationship between chronic periodontitis and stroke.

Methods

Electronic search was conducted to find out the association between chronic periodontitis and stroke in CBM (1978—2016) , VIP chinese database, CNKI, Medline (OVID, 1950—2016) , EMBASE (1984—2016) and CENTRAL (2016, Issue 9) . Hand search was applied to the Chinese journals in oral research. Two investigators performed reference screening, quality evaluation and data collection (including incidence of periodontitis, CAL, PI and levels of CRP) . Revman 5.3.3 was applied for Meta-analysis of the data.

Results

Twelve referen met the inclusion criteria (2 Chinese researches and 10 English researches) , including 2835 participants, 1396 of them with stroke. The result of Meta-analysis showed that the patients with stroke were more likely with chronic periodontitis[OR= 2.89, 95% CI= (2.00, 4.17) , P<0.001], more severe periodontitis[OR= 1.25, 95% CI= (0.50, 2.00) , P= 0.001] and poorer oral hygiene[OR= 0.32, 95% CI= (0.11, 0.54) , P= 0.004]. The levels of CRP increased obviously [OR= 5.38, 95% CI= (4.78, 5.97) , P<0.001].

Conclusion

Chronic periodontitis and stroke have a possible correlation.

图1 10篇入选研究牙周炎患病率Meta分析漏斗图
图2 10篇入选研究牙周炎患病率Meta分析森林图
图3 4篇入选研究临床附着丧失量的Meta分析森林图
图4 4篇入选研究牙菌斑指数的Meta分析森林图
图5 4篇入选研究血清C反应蛋白的Meta分析森林图
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