颞下颌关节骨关节病（TMJOA）是一种多因素疾病，其致病机制复杂，涉及滑膜炎性反应、软骨退变和髁突骨质破坏等多个方面。TMJOA传统治疗（如药物、物理和手术等方法）存在明显局限性，仅能缓解临床症状，无法促进组织的修复再生，目前尚无根治方法。富血小板血浆（PRP）作为一种生物制剂，富含生长因子等成分，通过促进细胞增殖、抑制炎症和调控局部微环境等作用，在组织再生和修复领域展现出巨大潜力。本文阐述TMJOA的病理过程，解析PRP的生物活性成分及其作用机制，总结其在骨关节病中的应用研究，分析其治疗TMJOA的可行性和临床效果，旨在为PRP在该领域的深入研究提供参考。

Temporomandibular joint osteoarthrosis is a multifactorial disease with complex pathogenic mechanisms, involving synovial inflammatory response, cartilage degeneration, and condylar bone destruction. Traditional treatments for this disease, such as medication, physical therapy, and surgery, have obvious limitations. They can only relieve clinical symptoms but fail to promote tissue repair and regeneration, and there is currently no radical cure. As a biological agent, platelet-rich plasma is rich in growth factors and other components. It has shown great potential in the field of tissue regeneration and repair through promoting cell proliferation, inhibiting inflammation, and regulating the local microenvironment, and has attracted much attention in the treatment of osteoarthrosis in recent years. This article elaborates on the pathological process of temporomandibular joint osteoarthrosis, analyzes the bioactive components of platelet-rich plasma and its mechanism of action, summarizes its application research in osteoarthrosis, and analyzes the feasibility and clinical effects of its treatment for temporomandibular joint osteoarthrosis, aiming to provide a reference for in-depth research on platelet-rich plasma in this field.