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中华口腔医学研究杂志(电子版) ›› 2025, Vol. 19 ›› Issue (06) : 405 -409. doi: 10.3877/cma.j.issn.1674-1366.2025.06.009

病例分析

下颌下腺分泌性癌1例并文献复习
汤伟伟, 徐丽娟, 李金, 绳兰兰()   
  1. 十堰市人民医院(湖北医药学院附属人民医院)口腔科,十堰 442000
  • 收稿日期:2025-04-02 出版日期:2025-12-01
  • 通信作者: 绳兰兰

Secretory carcinoma of the submandibular gland: A case report and literature review

Weiwei Tang, Lijuan Xu, Jin Li, Lanlan Sheng()   

  1. Department of Stomatology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China
  • Received:2025-04-02 Published:2025-12-01
  • Corresponding author: Lanlan Sheng
引用本文:

汤伟伟, 徐丽娟, 李金, 绳兰兰. 下颌下腺分泌性癌1例并文献复习[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(06): 405-409.

Weiwei Tang, Lijuan Xu, Jin Li, Lanlan Sheng. Secretory carcinoma of the submandibular gland: A case report and literature review[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(06): 405-409.

唾液腺分泌性癌(SSC)是2017年世界卫生组织第四版头颈部肿瘤分类中新增的一种唾液腺低级别恶性肿瘤,其临床罕见,好发于腮腺,其次为下颌下腺。目前,关于下颌下腺分泌性癌的病例报道极为有限。本文报道1例发生于下颌下腺分泌性癌病例,并进行文献复习。

Salivary secretory carcinoma (SSC) is a low-grade malignant tumor of the salivary gland, newly introduced in the fourth edition of the World Health Organization′s classification of head and neck tumors (2017). It is relatively rare in clinical practice, with very few reported cases involving the submandibular gland. This article reported one case of secretory carcinoma occurring in the submandibular gland and reviews related literature.

图1 左侧下颌下腺分泌性癌患者术前颈部计算机体层摄影术(CT)影像学图像 左侧胸锁乳突肌内见1个大小约6 cm × 3 cm软组织肿块影(箭头所示),密度均匀,边缘光滑;A:横断面;B:冠状面;C:矢状面。
图2 左侧下颌下腺分泌性癌患者术后组织病理学图像 A:排列呈囊性、腺管状和微囊状(苏木精-伊红 低倍放大);B:局部呈乳头状(苏木精-伊红 中倍放大);C:部分形态似甲状腺滤泡,肿瘤细胞呈立方形或多边形,胞浆丰富嗜酸性,异型性不明显(苏木精-伊红 高倍放大);D:过碘酸希夫反应(PAS)特殊染色(中倍放大)。
图3 左侧下颌下腺分泌性癌患者术后免疫组织化学染色结果(EnVision法 中倍放大) A:中枢神经特异性蛋白100(S-100)弥漫阳性表达;B:乳腺珠蛋白(mammaglobin)弥漫阳性表达;C:神经嵴转录因子10(Sox-10)阳性表达;D:胃肠道间质瘤免疫表型抗原蛋白1(Dog-1)阴性表达。
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