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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 54 -60. doi: 10.3877/cma.j.issn.1674-1366.2024.01.009

综述

机械敏感离子通道在牙源性细胞中作用的研究进展
徐志清, 杜宇†()   
  1. 中山大学附属口腔医院，光华口腔医学院，广东省口腔医学重点实验室，广东省口腔疾病临床医学研究中心，广州　510055
  • 收稿日期:2023-07-20 出版日期:2024-02-01
  • 通信作者: 杜宇

Research advances on the role of mechanosensitive ion channels in odontogenic cells

Zhiqing Xu, Yu Du†()   

  1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangdong Provincial Clinical Research Center of Oral Diseases, Guangzhou 510055, China
  • Received:2023-07-20 Published:2024-02-01
  • Corresponding author: Yu Du
  • Supported by:
    Natural Science Foundation of Guangdong Province(2021A1515010845); Medical Scientific Research Foundation of Guangdong Province(A2022126)
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引用本文：

徐志清, 杜宇. 机械敏感离子通道在牙源性细胞中作用的研究进展[J]. 中华口腔医学研究杂志(电子版), 2024, 18(01): 54-60.

Zhiqing Xu, Yu Du. Research advances on the role of mechanosensitive ion channels in odontogenic cells[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(01): 54-60.

机械敏感离子通道（MS离子通道）是一类能感知机械应力的重要蛋白，将细胞外机械刺激信号转化为电化学信号，导致离子跨膜流通，继而传递至胞内调控下游靶基因。牙源性细胞胞膜表面有多种MS离子通道表达，但其如何调控细胞功能和具体机制仍不明确。本文就MS离子通道的分类及其在牙源性细胞的表达和功能作一综述。

关键词: 机械敏感通道, 牙再生, 压电离子通道, 瞬时受体电位离子通道

As crucial proteins in sensing mechanical stress, mechanosensitive (MS) ion channels could transform external mechanical stimuli into electrochemical signals, enabling ion transmembrane movement. This movement signals the intracellular regulation of target genes. While various MS ion channels are present in odontogenic cell membranes, their roles in the cellular regulation and the exact mechanisms are still not fully understood. This review focused on the classification, expression, and functionality of MS ion channels in odontogenic cells.

Key words: Mechanosensitive channels, Tooth regeneration, PIEZO, TRP channels
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