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中华口腔医学研究杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 309 -313. doi: 10.3877/cma.j.issn.1674-1366.2021.05.010

综述

内质网应激在骨代谢及其稳态中的作用
林锐钿1, 李子涵1, 古丽莎1,†()   
  1. 1. 中山大学附属口腔医院，光华口腔医学院，广东省口腔医学重点实验室，广州　510055
  • 收稿日期:2020-11-16 出版日期:2021-10-01
  • 通信作者: 古丽莎

Endoplasmic reticulum stress in skeletal development and bone homostasis

Ruitian Lin1, Zihan Li1, Lisha Gu1,†()   

  1. 1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2020-11-16 Published:2021-10-01
  • Corresponding author: Lisha Gu
  • Supported by:
    National Natural Science Foundation of China(81873712); Science and Technology Planning Project of Guangzhou(201904010057)
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林锐钿, 李子涵, 古丽莎. 内质网应激在骨代谢及其稳态中的作用[J]. 中华口腔医学研究杂志(电子版), 2021, 15(05): 309-313.

Ruitian Lin, Zihan Li, Lisha Gu. Endoplasmic reticulum stress in skeletal development and bone homostasis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(05): 309-313.

骨稳态是破骨细胞和成骨细胞共同作用的过程。骨组织中存在大量的细胞外基质蛋白。在蛋白合成过程中，未折叠及错误折叠蛋白增多导致内质网应激，诱发肌醇必需酶1α（IRE1α）、内质网膜蛋白激酶（PERK）和活化转录因子6（ATF6）家族介导的非折叠蛋白应答。当过度应激时将造成软骨发育不良、骨关节炎和牙周炎骨吸收等疾病。本文就近年内质网应激在骨代谢中作用的研究进展做一综述，有助于进一步了解内质网应激在骨代谢及治疗相关疾病中的作用及意义。

关键词: 内质网应激, 非折叠蛋白应答, 细胞凋亡, 骨代谢

Bone homeostasis is a process of interaction between osteoclasts and osteoblasts, with abundant extracellular matrix proteins existing in bone tissue. During protein synthesis, the increase of unfolded and misfolded proteins lead to endoplasmic reticulum stress, which induce the unfolded protein responses mediated by IRE1α, PERK and ATF6 family. Excessive stress leads to chondrodysplasia, osteoarthritis and periodontitis bone resorption. This review focuses on the role of endoplasmic reticulum stress in bone metabolism and it is of great significance for our further understanding of bone metabolism and treatment of related diseases.

Key words: Endoplasmic reticulum stress, Unfolded protein response, Apoptosis, Bone metabolism
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