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中华口腔医学研究杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 300 -304. doi: 10.3877/cma.j.issn.1674-1366.2021.05.008

病例分析

下颌下腺多形性腺瘤复发伴双侧多发肺转移一例
寇鹏1, 李志萍2,(), 李迎梅1, 孟箭2   
  1. 1. 蚌埠医学院口腔医学院 233000
    2. 徐州市中心医院口腔科 221000
  • 收稿日期:2021-07-17 出版日期:2021-10-01
  • 通信作者: 李志萍

Recurrent pleomorphic adenoma of submandibular gland with bilateral multiple pulmonary metastasis: A case report

Peng Kou1, Zhiping Li2,(), Yingmei Li1, Jian Meng2   

  1. 1. School of Stomatology, Bengbu Medical College, Bengbu 233000, China
    2. Department of Stomatology, the Central Hospital of Xuzhou, Xuzhou 221000, China
  • Received:2021-07-17 Published:2021-10-01
  • Corresponding author: Zhiping Li
引用本文:

寇鹏, 李志萍, 李迎梅, 孟箭. 下颌下腺多形性腺瘤复发伴双侧多发肺转移一例[J]. 中华口腔医学研究杂志(电子版), 2021, 15(05): 300-304.

Peng Kou, Zhiping Li, Yingmei Li, Jian Meng. Recurrent pleomorphic adenoma of submandibular gland with bilateral multiple pulmonary metastasis: A case report[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(05): 300-304.

多形性腺瘤是唾液腺肿瘤中最为常见的良性肿瘤,极少发生转移,临床及组织病理学将远处转移者称为转移性多形性腺瘤(MPA)。本文报道一例罕见的原发于下颌下腺的多形性腺瘤,术后复发伴双肺多发转移。给予患者下颌下腺区及肺部肿物联合手术切除术。现通过文献复习,分析该类疾病的临床病理特征、转移特点及治疗的策略要点。

Pleomorphic adenoma is the most common benign tumor in salivary gland and its metastasis rarely occurs. The local or distant metastatic tumor of benign pleomorphic adenoma is clinically and histopathologically called metastatic pleomorphic adenoma (MPA) . A rare case of pleomorphic adenoma was reported in this article. This patient suffered from a pleomorphic adenoma originally in the left submandibular gland, which was treated by surgical removal two years ago. Subsequently, a local recurrence of the pleomorphic adenoma with multiple bilateral pulmonary metastasis was found, so that the submaxillary area and lung masses were surgically exenterated. Upon the review of literature, the clinicopathological and metastatic features, as well as the key therapeutic strategies of this disease were discussed in this article.

图1 肺转移性多形性腺瘤患者术前照片及影像学检查情况 A:复发术前侧面像;B:2019年手术前颌下区计算机体层摄影术(CT)显示左侧下颌下肿物与下颌下腺关系密切;C:2019年术前胸部正位片未见异常;D:2021年颌下区CT提示左侧颌下囊性占位;E:2021年胸部CT见两肺内多发大小不等结节;F~H:2021年正电子发射计算机体层显像仪(PET/CT)提示左侧颌下及肺部FDG高代谢信号
图3 肺部肿瘤镜下表现(苏木精-伊红)3A为低倍放大;3B为中倍放大;3C为高倍放大;由上皮和间充质细胞组成的肿瘤细胞排列呈腺管样,见大量黏液软骨样组织,周围可见肺泡组织
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