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中华口腔医学研究杂志(电子版) ›› 2020, Vol. 14 ›› Issue (04) : 201 -206. doi: 10.3877/cma.j.issn.1674-1366.2020.04.001

所属专题： 口腔医学； 文献；

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m6A RNA甲基化修饰参与干细胞多向分化调控的研究进展
张旭1, 秦文1, 刘佳1, 金作林1,†()   
  1. 1. 军事口腔医学国家重点实验室，国家口腔疾病临床医学研究中心，陕西省口腔疾病临床医学研究中心，第四军医大学口腔医院正畸科，西安　710032
  • 收稿日期:2020-02-25 出版日期:2020-08-01
  • 通信作者: 金作林

Research progress of m6A RNA methylation modification involved in the regulation of stem cell multidirectional differentiation

Xu Zhang1, Wen Qin1, Jia Liu1, Zuolin Jin1,†()   

  1. 1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China
  • Received:2020-02-25 Published:2020-08-01
  • Corresponding author: Zuolin Jin
  • About author:
    Corresponding author: Jin Zuolin, Email:
  • Supported by:
    National Natural Science Foundation of China(81701002)
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张旭, 秦文, 刘佳, 金作林. m6A RNA甲基化修饰参与干细胞多向分化调控的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2020, 14(04): 201-206.

Xu Zhang, Wen Qin, Jia Liu, Zuolin Jin. Research progress of m6A RNA methylation modification involved in the regulation of stem cell multidirectional differentiation[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2020, 14(04): 201-206.

m6A修饰是RNA中普遍存在的甲基化修饰方式之一，属于转录后水平的表观遗传调控。m6A RNA甲基化修饰包括编写、擦除和读取过程，通过参与干细胞多向分化，从而影响多种生物学功能。近年来研究发现，无论在生理或者病理状态下，m6A修饰均可以通过调控干细胞的自我更新和分化，从而改变干细胞的复制能力和分化方向，进而影响组织成熟过程和疾病的发生与进展。本文对m6A在RNA中的修饰机制进行阐述，重点对m6A修饰参与几种干细胞的自我更新和多向分化调控展开论述。

关键词: m6A修饰, 干细胞, RNA甲基化

m6A modification is one of the most pervasive methylation modifications in RNA, which belongs to the epigenetic regulation at the post-transcriptional level. m6A RNA methylation modification includes the process of writing, erasing and reading, which affects a variety of biological functions by participating in the multidirectional differentiation of stem cells. In recent years, it has been found that whether in physiological or pathological state, m6A modification can change the replication ability and differentiation direction of stem cells by regulating the self-renewal and differentiation of stem cells, and subsequently affect the process of tissue maturation and disease progression. This article described the modification mechanism of m6A in RNA, and focused on the role of m6A modification in the regulation of self-renewal and multidirectional differentiation of several kinds of stem cells.

Key words: m6A modification, Stem cells, RNA methylation
图1 m6A mRNA修饰的编写、擦除与读取过程[11]
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