| [1] |
Gao L, Xu T, Huang G，et al. Oral microbiomes：more and more importance in oral cavity and whole body[J]. Protein Cell，2018，9(5): 488-500. DOI: 10.1007/s13238-018-0548-1. |
| [2] |
Krishnan K, Chen T, Paster BJ. A practical guide to the oral microbiome and its relation to health and disease[J]. Oral Dis，2017，23(3): 276-286. DOI: 10.1111/odi.12509. |
| [3] |
|
| [4] |
Belibasakis GN, Meier A, Guggenheim B，et al. The ranklopg system is differentially regulated by supragingival and subgingival biofilm supernatants[J]. Cytokine，2011，55(1): 98-103. DOI: 10.1016/j.cyto.2011.03.009. |
| [5] |
Donos N, Park JC, Vajgel A，et al. Description of the periodontal pocket in preclinical models：Limitations and considerations[J]. Periodontol 2000，2018，76(1): 16-34. DOI: 10.1111/prd.12155. |
| [6] |
Fawzy El-Sayed KM, Dorfer CE. Animal models for periodontal tissue engineering：A knowledge-generating process[J]. Tissue Eng Part C Methods，2017，23(12): 900-925. DOI: 10.1089/ten.TEC.2017.0130. |
| [7] |
Janus MM, Keijser BJ, Bikker FJ，et al. In vitro phenotypic differentiation towards commensal and pathogenic oral biofilms [J]. Biofouling，2015，31(6): 503-510. DOI: 10.1080/08927014.2015.1067887. |
| [8] |
Hajishengallis G, Lamont RJ, Graves DT. The enduring importance of animal models in understanding periodontal disease[J]. Virulence，2015，6(3): 229-235. DOI: 10.4161/21505594.2014.990806. |
| [9] |
Alfonso-Rodríguez CA, González-Andrades E, Jaimes-Parra BD，et al. Ex vivo and in vivo modulatory effects of umbilical cord wharton′s jelly stem cells on human oral mucosa stroma substitutes[J]. Histol Histopathol，2015，30(11): 1321-1332. DOI: 10.14670hh-11-628. |
| [10] |
Dave JR, Tomar GB. Dental tissue-derived mesenchymal stem cells and their applications in tissue engineering[J]. Crit Rev Biomed Eng，2018，46(5): 429-468. DOI: 10.1615/CritRevBiomedEng.2018027342. |
| [11] |
Buskermolen JK, Reijnders CM, Spiekstra SW，et al. Development of a full-thickness human gingiva equivalent constructed from immortalized keratinocytes and fibroblasts[J]. Tissue Eng Part C Methods，2016，22(8): 781-791. DOI: 10.1089/ten.tec.2016.0066. |
| [12] |
Basso FG, Hebling J, Marcelo CL，et al. Development of an oral mucosa equivalent using a porcine dermal matrix[J]. Br J Oral Maxillofac Surg，2017，55(3): 308-311. DOI: 10.1016/j.bjoms.2016.09.019. |
| [13] |
Kuo S, Kim HM, Wang Z，et al. Comparison of two decellularized dermal equivalents[J]. J Tissue Eng Regen Med，2018，12(4): 983-990. DOI: 10.1002/term.2530. |
| [14] |
Conway JRW, Vennin C, Cazet AS，et al. Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology[J]. Sci Rep，2017，7(1): 16887. DOI: 10.1038/s41598-017-17177-5. |
| [15] |
Dang JM, Leong KW. Natural polymers for gene delivery and tissue engineering[J]. Adv Drug Deliv Rev，2006，58(4): 487-499. DOI: 10.1016/j.addr.2006.03.001. |
| [16] |
Gunatillake PA, Adhikari R. Biodegradable synthetic polymers for tissue engineering[J]. Eur Cell Mater，2003，5: 1-16；discussion 16. DOI: 10.0000/PMID14562275. |
| [17] |
Kinikoglu B, Rodriguez-Cabello JC, Damour O，et al. A smart bilayer scaffold of elastin-like recombinamer and collagen for soft tissue engineering[J]. J Mater Sci Mater Med，2011，22(6): 1541-1554. DOI: 10.1007/s10856-011-4315-6. |
| [18] |
Almela T, Brook IM, Moharamzadeh K. Development of three-dimensional tissue engineered bone-oral mucosal composite models[J]. J Mater Sci Mater Med，2016，27(4): 65. DOI: 10.1007/s10856-016-5676-7. |
| [19] |
Chai WL, Moharamzadeh K, Brook IM，et al. Development of a novel model for the investigation of implant-soft tissue interface [J]. J Periodontol，2010，81(8): 1187-1195. DOI: 10.1902/jop.2010.090648. |
| [20] |
Liu X, Zhang Z, Pan S，et al. Interaction between the wnt/β-catenin signaling pathway and the emmprin/mmp-2，9 route in periodontitis[J]. J Periodontal Res，2018，53(5): 842-852. DOI: 10.1111/jre.12574. |
| [21] |
Xiao L, Okamura H, Kumazawa Y. Three-dimensional inflammatory human tissue equivalents of gingiva[J]. J Vis Exp，2018(134): e57157. DOI: 10.3791/57157. |
| [22] |
Oscarsson J, Claesson R, Lindholm M，et al. Tools of aggregatibacter actinomycetemcomitans to evade the host response[J]. J Clin Med，2019，8(7): E1079. DOI: 10.3390/jcm8071079. |
| [23] |
Bedran TB, Mayer MP, Spolidorio DP，et al. Synergistic anti-inflammatory activity of the antimicrobial peptides human beta-defensin-3（hbd-3）and cathelicidin（ll-37）in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts[J]. PloS one，2014，9(9): e106766. DOI: 10.1371/journal.pone.0106766. |
| [24] |
de Carvalho Dias K, de Sousa DL, Barbugli PA，et al. Development and characterization of a 3d oral mucosa model as a tool for host-pathogen interactions[J]. J Microbiol Methods，2018，152: 52-60. DOI: 10.1016/j.mimet.2018.07.004. |
| [25] |
Gursoy UK, Pöllänen M, Könönen E，et al. Biofilm formation enhances the oxygen tolerance and invasiveness of Fusobacterium nucleatum in an oral mucosa culture model[J]. J Periodontol，2010，81(7): 1084-1091. DOI: 10.1902/jop.2010.090664. |
| [26] |
Guggenheim B, Giertsen E, Schupbach P，et al. Validation of an in vitro biofilm model of supragingival plaque[J]. J Dent Res，2001，80(1): 363-370. DOI: 10.1177/00220345010800011201. |
| [27] |
Buskermolen JK, Janus MM, Roffel S，et al. Saliva-derived commensal and pathogenic biofilms in a human gingiva model [J]. J Dent Res，2018，97(2): 201-208. DOI: 10.1177/0022034517729998. |
| [28] |
Bao K, Papadimitropoulos A, Akgul B，et al. Establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system[J]. Virulence，2015，6(3): 265-273. DOI: 10.4161/21505594.2014.978721. |
| [29] |
Shaddox LM, Wiedey J, Calderon NL，et al. Local inflammatory markers and systemic endotoxin in aggressive periodontitis[J]. J Dent Res，2011，90(9): 1140-1144. DOI: 10.1177/0022034511413928. |
| [30] |
Bao K, Belibasakis GN, Selevsek N，et al. Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket[J]. Sci Rep，2015，5: 15999. DOI: 10.1038/srep15999. |
| [31] |
Gursoy UK, Pöllänen M, Könönen E，et al. A novel organotypic dento-epithelial culture model：effect of Fusobacterium nucleatum biofilm on B-defensin-2，-3，and LL-37 expression [J]. J Periodontol，2012，83(2): 242-247. DOI: 10.1902/jop.2011.110177. |
| [32] |
Pöllänen MT, Gursoy UK, Könönen E，et al. Fusobacterium nucleatum biofilm induces epithelial migration in an organotypic model of dento-gingival junction[J]. J Periodontol，2012，83(10): 1329-1335. DOI: 10.1902/jop.2012.110535. |
| [33] |
Ingendoh-Tsakmakidis A, Mikolai C, Winkel A，et al. Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model[J]. Cell Microbiol，2019，21(10): e13078. DOI: 10.1111/cmi.13078. |
| [34] |
Shang L, Deng D, Buskermolen JK，et al. Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function[J]. Sci Rep，2018，8(1): 16061. DOI: 10.1038/s41598-018-34390-y. |
| [35] |
Morin MP, Grenier D. Regulation of matrix metalloproteinase secretion by green tea catechins in a three-dimensional co-culture model of macrophages and gingival fibroblasts[J]. Arch Oral Biol，2017，75: 89-99. DOI: 10.1016/j.archoralbio.2016.10.035. |
| [36] |
Meier F, Freyer N, Brzeszczynska J，et al. Hepatic differentiation of human ipscs in different 3d models：A comparative study[J]. Int J Mol Med，2017，40(6): 1759-1771. DOI: 10.3892/ijmm.2017.3190. |