切换至 "中华医学电子期刊资源库"

中华口腔医学研究杂志(电子版) ›› 2019, Vol. 13 ›› Issue (01) : 13 -18. doi: 10.3877/cma.j.issn.1674-1366.2019.01.003

所属专题: 文献

基础研究

保留颊侧部分牙根对牙槽窝改建影响的动物研究
邓衍铭1, 董豫1, 许若谷1, 胡修城1, 邓飞龙1,()   
  1. 1. 中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室,广州 510055
  • 收稿日期:2018-09-12 出版日期:2019-02-01
  • 通信作者: 邓飞龙

The influence of buccal partial root on socket alteration: an animal study

Yanming Deng1, Yu Dong1, Ruogu Xu1, Xiucheng Hu1, Feilong Deng1,()   

  1. 1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2018-09-12 Published:2019-02-01
  • Corresponding author: Feilong Deng
  • About author:
    Corresponding author: Deng Feilong, Email:
  • Supported by:
    Science and Technology Major Project of Guangdong Province(2017B090912004)
引用本文:

邓衍铭, 董豫, 许若谷, 胡修城, 邓飞龙. 保留颊侧部分牙根对牙槽窝改建影响的动物研究[J/OL]. 中华口腔医学研究杂志(电子版), 2019, 13(01): 13-18.

Yanming Deng, Yu Dong, Ruogu Xu, Xiucheng Hu, Feilong Deng. The influence of buccal partial root on socket alteration: an animal study[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2019, 13(01): 13-18.

目的

研究牙槽窝内保留颊侧部分牙根,对牙槽窝颊侧骨板高度及牙槽窝骨愈合速度的影响。

方法

选择4只成年Beagle犬双侧下颌及第二、三、四前磨牙的远中根作为实验位点。采用平行对照随机分为以下3组:(1)血液充盈组:拔除前磨牙远中根,血液充盈后关闭创口;(2)Bio-Oss Collagen组:拔除前磨牙远中根,牙槽窝内植入Bio-Oss Collagen,牙槽窝表面覆盖Bio-Gide,严密关闭创口;(3)部分牙根+血液充盈组:去除前磨牙远中根牙冠及牙根的舌侧部分,保留颊侧部分牙根,血液充盈牙槽窝后关闭创口。术后12周拍摄Beagle犬下颌锥形束CT(CBCT),比较颊侧骨板高度变化以及牙槽窝内的成骨情况。采用SPSS 21.0统计软件对颊侧骨板高度吸收量进行秩和检验,检验水准α = 0.05。

结果

术后12周,血液充盈组颊侧骨板高度降低(1.63 ± 0.67)mm,Bio-Oss Collagen组颊侧骨板高度降低(0.77 ± 0.58)mm,部分牙根+血液充盈组颊侧骨板高度降低(0.06 ± 0.10)mm。Bio-Oss Collagen组牙槽窝颊侧骨板吸收量小于血液充盈组,差异具有统计学意义(Z=-2.205,P = 0.027),部分牙根+血液充盈组颊侧骨板吸收量小于血液充盈组,差异具有统计学意义(Z=-3.361,P= 0.001),部分牙根+血液充盈组颊侧骨板吸收量小于Bio-Oss Collagen组,差异具有统计学意义(Z=-2.260,P= 0.024)。术后12周血液充盈组牙槽窝中间区域显示低密影,Bio-Oss Collagen组牙槽窝高密影,形态与牙根轮廓相似,部分牙根+血液充盈组可见较多地松质骨影像。

结论

牙槽窝内保留颊侧部分牙根,相比牙槽窝内植入Bio-Oss Collagen,能更好地保存颊侧骨板高度。保留颊侧部分牙根具有促进牙槽窝内骨生成,加快牙槽窝骨愈合速度的作用。

Objective

To observe the buccal bone plate height and socket alteration with a buccal partial root in a tooth socket.

Methods

Four adult male Beagle dogs were used. Bilateral mandible the 2nd to 4th premolar distal roots were randomly divided into three groups, i.e., the group of blood filling (the root was extracted and the wound was sutured after blood filling) , the group of Bio-Oss Collagen (the root was extracted and the wound was filled with Bio-Oss Collagen and covered with Bio-Gide before suturing) and the group of buccal partial root combined with blood filling (the lingual partial root was removed while the buccal partial root was kept; the wound was sutured after blood filling) . CBCT analysis was carried out on the first day and 12th week post operation. Vertical buccal bone plate alteration and osteogenesis effect in sockets were observed with the 12th week CBCT images. Statistical analysis was carried out with SPSS 21.0 and the significance level was 0.05.

Results

The buccal bone plate height in the group of blood filling reduced (1.63 ± 0.67) mm, while that of the group of Bio-Oss Collagen and the group of buccal partial root combined with blood filling was (0.77 ± 0.58) mm and (0.06 ± 0.10) mm, respectively. The vertical height alteration of buccal bone plate was much less in the group of Bio-Oss Collagen than the group of blood filling (Z=-2.205, P= 0.027) . So was the group of buccal partial root combined with blood filling compared with the group of blood filling (Z=-3.361, P= 0.001) and the group of buccal partial root combined with blood filling compared with the group of Bio-Oss Collagen (Z=-2.260, P= 0.024) . The sockets were comparatively empty in the group of blood filling. High density bone graft substitute was observed in the group of Bio-Oss Collagen. Cancellous bone was observed in the group of buccal partial root combined with blood filling.

Conclusions

A buccal partial root resided in the tooth socket seems have a better ability to maintain the height of the buccal bone plate than Bio-Oss Collagen. A buccal partial root may accelerate new bone formation and be in favor of tooth socket healing.

表1 不同处理方法12周后Beagle犬牙槽窝颊侧骨板高度的变化( ± s,mm)
图1 血液充盈组牙槽窝骨愈合的锥形束CT图像 A:冠状面;B:矢状面(层厚:2 mm)
图2 Bio-Oss Collagen组牙槽窝骨愈合的锥形束CT图像 A:冠状面;B:矢状面(层厚:2 mm)
图3 部分牙根+血液充盈组牙槽窝骨愈合的锥形束CT图像 A:冠状面;B:矢状面(层厚:2 mm)
[1]
Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog[J]. J Clin Periodontol,2005,32(2):212-218. DOI:10.1111/j.1600-051X.2005.00642.x.
[2]
Schropp L, Wenzel A, Kostopoulos L,et al. Bone healing and soft tissue contour changes following single-tooth extraction:a clinical and radiographic 12-month prospective study[J]. Int J Periodontics Restorative Dent,2003,23(4):313-323. DOI:10.1054/ijom.2002.0384.
[3]
Araújo MG, Silva CO, Misawa M,et al. Alveolar socket healing:what can we learn?[J]. Periodontology 2000,2015,68(1):122-134. DOI:10.1111/prd.12082.
[4]
Sharma A, Oberoi SS, Saxena S. Submergence of vital roots for the preservation of residual ridge:a clinical study[J]. Oral Health Prev Dent,2012,10(3):259-265. DOI:10.4047/jap.2012.4.4.259.
[5]
Salama M, Ishikawa T, Salama H,et al. Advantages of the root submergence technique for pontic site development in esthetic implant therapy[J]. Int J Periodontics Restorative Dent,2007,27(6):521-527.
[6]
Wong KM, Chneh CM, Ang CW. Modified root submergence technique for multiple implant-supported maxillary anterior restorations in a patient with thin gingival biotype:a clinical report[J]. J Prosthet Dent,2012,107(6):349-352. DOI:10.1016/S0022-3913(12)00071-6.
[7]
Araújo MG, Sukekava F, Wennström JL,et al. Ridge alterations following implant placement in fresh extraction sockets:an experimental study in the dog[J]. J Clin Periodontol,2005,32(6):645-652. DOI:10.1111/j.1600-051X.2005.00726.x.
[8]
Hürzeler MB, Zuhr O, Schupbach P,et al. The socket-shield technique:a proof-of-principle report[J]. J Clin Periodontol,2010,37(9):855-862. DOI:10.1111/j.1600-051X.2010.01595.x.
[9]
Cherel F, Etienne D. Papilla preservation between two implants:a modified socket-shield technique to maintain the scalloped anatomy?A case report[J]. Quintessence Int,2014,45(1):23-30. DOI:10.3290/j.qi.a30765.
[10]
Barone A, Aldini NN, Fini M,et al. Xenograft versus extraction alone for ridge preservation after tooth removal:a clinical and histomorphometric study[J]. J Periodontol,2008,79(8):1370-1377. DOI:10.1902/jop.2008.070628.
[11]
Araújo MG, da Silva JCC, de Mendonça AF,et al. Ridge alterations following grafting of fresh extraction sockets in man. A randomized clinical trial[J]. Clin Oral Implants Res,2015,26(4):407-412. DOI:10.1111/clr.12366.
[12]
Bäumer D, Zuhr O, Rebele S,et al. The socket-shield technique:first histological,clinical,and volumetrical observations after separation of the buccal tooth segment - a pilot study[J]. Clin Implant Dent Relat Res,2015,17(1):71-82. DOI:10.1111/cid.12076.
[13]
Araújo M, Linder E, Lindhe J. Effect of a xenograft on early bone formation in extraction sockets:an experimental study in dog[J]. Clin Oral Implants Res,2009,20(1):1-6. DOI:10.1111/j.1600-0501.2008.01606.x.
[14]
Antunes AA, Oliveira Neto P, de Santis E,et al. Comparisons between Bio-Oss® and Straumann® Bone Ceramic in immediate and staged implant placement in dogs mandible bone defects[J]. Clin Oral Implants Res,2013,24(2):135-142. DOI:10.1111/j.1600-0501.2011.02385.x.
[15]
Tsukiboshi M, Tsukiboshi T. Bone morphology after delayed tooth replantation - case series[J]. Dent Traumatol,2014,30(6):477-483. DOI:10.1111/edt.12111.
[16]
Kan JY, Rungcharassaeng K. Proximal socket shield for interimplant papilla preservation in the esthetic zone[J]. Int J Periodontics Restorative Dent,2013,33(1):e24-e31. DOI:10.11607/prd.1346.
[1] 杨琳, 尹如铁. 外阴白色病变病因研究及治疗现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(02): 157-165.
[2] 宋勤琴, 李双汝, 李林, 杜鹃, 刘继松. 间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 550-553.
[3] 彭玲, 吴红, 宛仕勇, 陈斓, 叶子青, 周静. 胶原酶软膏联合水胶体敷料应用于深Ⅱ度烧伤创面治疗的效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 511-516.
[4] 程宇欣, 张伟, 孔维诗, 孙瑜. 胶原蛋白敷料在创面修复中应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 73-77.
[5] 张洁宇, 朱文君, 高伟, 王新昇, 贺贝贝, 吴世乐. 青海地区不同海拔男性腹股沟疝患者腹壁组织Ⅰ、Ⅲ型胶原纤维表达的研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 383-389.
[6] 赛甫丁·艾比布拉, 买买提·依斯热依力, 李义亮, 王永康, 王志, 克力木·阿不都热依木. 不同材质补片修补对腹壁疝大鼠腹横筋膜组织转化生长因子-β1及Collagen合成代谢的作用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(02): 161-167.
[7] 张升敏, 黄健斌, 陈亮, 马克强. Ⅰ、Ⅲ型胶原蛋白在成人腹股沟斜疝及直疝患者腹横筋膜和疝囊的表达[J/OL]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 516-521.
[8] 陈惠燕, 吴瑶, 黄宗炫, 卜歆, 王庆惠, 纪辉涛, 陈银珍, 赵虎. 肾间质纤维化中胶原/DDR2 信号活化对肾成纤维细胞增殖和迁移功能影响的实验研究[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 294-302.
[9] 梅杰, 徐瑞, 蔡芸, 朱一超. 纤维化对肿瘤浸润免疫细胞的影响——“硬冷肿瘤”的形成[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 257-263.
[10] 周敏, 徐阳, 胡莹, 黄先凤. 维持性血液透析患者血清β-CTX、N-MID 和PICP 与冠状动脉钙化的关系及其诊断价值[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 256-260.
[11] 马萍, 鲁静, 兰长骏. 跨上皮和去上皮快速角膜交联术治疗进展期圆锥角膜的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 206-211.
[12] 徐静, 申笛, 孙西宇, 周堃, 王亚妮, 韦伟. 去上皮与跨上皮快速角膜胶原交联术治疗圆锥角膜长期疗效的临床观察[J/OL]. 中华眼科医学杂志(电子版), 2023, 13(06): 332-337.
[13] 秦维, 王丹, 孙玉, 霍玉玲, 祝素平, 郑艳丽, 薛瑞. 血清层粘连蛋白、Ⅳ型胶原蛋白对代偿期肝硬化食管胃静脉曲张出血的预测价值[J/OL]. 中华消化病与影像杂志(电子版), 2023, 13(06): 447-451.
[14] 刘世航, 周帅, 秦士吉, 程晓东, 丁凯, 王海程, 李超, 卢军丽, 吕红芝. 矿化胶原在骨缺损治疗中应用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2023, 17(12): 1320-1324.
[15] 姜晓宇, 付迪, 陈雪英, 申程, 甘立军. 胶原在心肌梗死后心脏重构中的研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(01): 25-30.
阅读次数
全文


摘要