| [1] |
Krzyściak W，Jurczak A，Kościelniak D，et al. The virulence of Streptococcus mutans and the ability to form biofilms[J]. Eur J Clin Microbiol Infect Dis，2014，33（4）：499-515.
|
| [2] |
Lemos JA，Quivey RG Jr，Koo H，et al. Streptococcus mutans：a new Gram-positive paradigm？[J]. Microbiology，2013，159（Pt 3）：436-445.
|
| [3] |
Lemos JA，Abranches J，Burne RA. Responses of cariogenic streptococci to environmental stresses[J]. Curr Issues Mol Biol，2005，7（1）：95-107.
|
| [4] |
Frees D，Savijoki K，Varmanen P，et al. Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC，Gram-positive bacteria[J]. Mol Microbiol，2007，63（5）：1285-1295.
|
| [5] |
Gottesman S，Squires C，Pichersky E，et al. Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes[J]. Proc Natl Acad Sci U S A，1990，87（9）：3513-3517.
|
| [6] |
Lemos JA，Burne RA. Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans[J]. J Bacteriol，2002，184（22）：6357-6366.
|
| [7] |
Kirstein J，Molière N，Dougan DA，et al. Adapting the machine：adaptor proteins for Hsp100/Clp and AAA+ proteases[J]. Nat Rev Microbiol，2009，7（8）：589-599.
|
| [8] |
Olivares AO，Baker TA，Sauer RT. Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines[J]. Nat Rev Microbiol，2016，14（1）：33-44.
|
| [9] |
Rosenzweig R，Farber P，Velyvis A，et al. ClpB N-terminal domain plays a regulatory role in protein disaggregation[J]. Proc Natl Acad Sci U S A，2015，112（50）：E6872-E6881.
|
| [10] |
Trentini DB，Suskiewicz MJ，Heuck A，et al. Arginine phosphorylation marks proteins for degradation by a Clp protease [J]. Nature，2016，539（7627）：48-53.
|
| [11] |
Kajfasz JK，Abranches J，Lemos JA. Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans[J]. Microbiology，2011，157（10）：2880-2890.
|
| [12] |
Zhang J，Banerjee A，Biswas I. Transcription of clpP is enhanced by a unique tandem repeat sequence in Streptococcus mutans [J]. J Bacteriol，2009，191（3）：1056-1065.
|
| [13] |
Len AC，Harty DW，Jacques NA. Stress-responsive proteins are upregulated in Streptococcus mutans during acid tolerance[J]. Microbiology，2004，150（5）：1339-1351.
|
| [14] |
Tao L，Chattoraj P，Biswas I. CtsR regulation in mcsAB-deficient Gram-positive bacteria[J]. J Bacteriol，2012，194（6）：1361-1368.
|
| [15] |
Tao L，Biswas I. ClpL is required for folding of CtsR in Streptococcus mutans[J]. J Bacteriol，2013，195（3）：576-584.
|
| [16] |
Niu G，Okinaga T，Qi F，et al. The Streptococcus mutans IrvR repressor is a CI-like regulator that functions through autocleav-age and Clp-dependent proteolysis[J]. J Bacteriol，2010，192（6）：1586-1595.
|
| [17] |
Levchenko I，Seidel M，Sauer RT，et al. A specificity-enhancing factor for the ClpXP degradation machine[J]. Science，2000，289（5488）：2354-2356
|
| [18] |
Tao L，Biswas I. Degradation of SsrA-tagged proteins in streptococci[J]. Microbiology，2015，161（Pt 4）：884-894.
|
| [19] |
Huang YH，Guan HH，Chen CJ，et al. Staphylococcus aureus single-stranded DNA-binding protein SsbA can bind but cannot stimulate PriA helicase[J]. PLoS ONE，2017，12（7）：e0182060.
|
| [20] |
Jana B，Tao L，Biswas I. Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in Streptococcus mutans [J]. mSphere，2016，1（6）：e00287-16.
|
| [21] |
Kajfasz JK，Rivera-Ramos I，Abranches J，et al. Two Spx proteins modulate stress tolerance，survival，and virulence in Streptococcus mutans[J]. J Bacteriol，2010，192（10）：2546-2556.
|
| [22] |
Pamp SJ，Frees D，Engelmann S，et al. Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococ-cus aureus[J]. J Bacteriol，2006，188（13）：4861-4870.
|
| [23] |
Kajfasz JK，Martinez AR，Rivera-Ramos I，et al. Role of Clp proteins in expression of virulence properties of Streptococcus mutans[J]. J Bacteriol，2009，191（7）：2060-2068.
|
| [24] |
Elsholz AKW，Hempel K，Michalik S，et al. Activity Control of the ClpC Adaptor McsB in Bacillus subtilis[J]. J Bacteriol，2011，193（15）：3887-3893.
|
| [25] |
Dong G，Tian XL，Gomez ZA，et al. Regulated proteolysis of the alternative sigma factor SigX in Streptococcus mutans：implica-tion in the escape from competence[J]. BMC Microbiol，2014（14）：183.
|
| [26] |
Hou XH，Zhang JQ，Song XY，et al. Contribution of ClpP to stress tolerance and virulence properties of Streptococcus mutans [J]. J Basic Microbiol，2014，54（11）：1222-1232.
|
| [27] |
Zhang JQ，Hou XH，Song XY，et al. ClpP affects biofilm formation of Streptococcus mutans differently in the presence of cariogenic carbohydrates through regulating gtfBC and ftf[J]. Curr Microbiol，2015，70（5）：716-723.
|
| [28] |
王拓，于丹妮.酪蛋白裂解酶P对变异链球菌致龋性的影响[J].国际口腔医学杂志，2012，39（2）：226-229.
|
| [29] |
Deng DM，Ten CJ，Crielaard W. The adaptive response of Streptococcus mutans towards oral care products：involvement of the ClpP serine protease[J]. Eur J Oral Sci，2007，115（5）：363-370.
|
| [30] |
Chattoraj P，Banerjee A，Biswas S，et al. ClpP of Streptococcus mutans differentially regulates expression of genomic islands，mutacin production，and antibiotic tolerance[J]. J Bacteriol，2010，192（5）：1312-1323.
|
| [31] |
Vasudevan D，Rao SP，Noble CG. Structural basis of mycobacte-rial inhibition by cyclomarin A[J]. J Biol Chem，2013，288（43）：30883-30891.
|
| [32] |
McGillivray SM，Tran DN，Ramadoss NS，et al. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics[J]. Antimicrob Agents Chemother，2012，56（4）：1854-1861.
|
| [33] |
Malik IT，Brötz-Oesterhelt H. Conformational control of the bacterial Clp protease by natural product antibiotics[J]. Nat Prod Rep，2017，34（7）：815-831.
|
| [34] |
Famulla K，Sass P，Malik I，et al. Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease[J]. Mol Microbiol，2016，101（2）：194-209.
|