| [1] |
Zhou J, Schmid T, Schnitzer S，et al. Tumor hypoxia and cancer progression[J]. Cancer Lett，2006，237(1):10-21.
|
| [2] |
Höckel M, Vaupel P. Tumor hypoxia：definitions and current clinical，biologic，and molecular aspects[J]. J Natl Cancer Inst，2001，93(4):266-276.
|
| [3] |
Rohwer N, Cramer T. Hypoxia-mediated drug resistance：novel insights on the functional interaction of HIFs and cell death pathways[J]. Drug Resist Updat，2011，14(3):191-201.
|
| [4] |
Zheng Y, Ni Y, Huang X，et al. Overexpression of HIF-1α indicates a poor prognosis in tongue carcinoma and may be associated with tumour metastasis[J]. Oncol Lett，2013，5(4):1285-1289.
|
| [5] |
Chi YH, Paeng SK, Kim MJ，et al. Redox-dependent functional switching of plant proteins accompanying with their structural changes[J]. Front Plant Sci，2013(4):277.
|
| [6] |
Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism[J]. Nat Rev Cancer，2011，11(2):85-95.
|
| [7] |
Powis G, Kirkpatrick DL. Thioredoxin signaling as a target for cancer therapy[J]. Curr Opin Pharmacol，2007，7(4):392-397.
|
| [8] |
Sahaf B, Söderberg A, Spyrou G，et al. Thioredoxin expression and localization in human cell lines：detection of full-length and truncated species[J]. Exp Cell Res，1997，236(1):181-192.
|
| [9] |
Noike T, Miwa S, Soeda J，et al. Increased expression of thioredoxin-1，vascular endothelial growth factor，and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer[J]. Hum Pathol，2008，39(2):201-208.
|
| [10] |
Li C, Thompson MA, Tamayo AT，et al. Over-expression of Thioredoxin-1 mediates growth，survival，and chemoresistance and is a druggable target in diffuse large B-cell lymphoma[J]. Oncotarget，2012，3(3):314-326.
|
| [11] |
You BR, Shin HR, Han BR，et al. PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner[J]. Tumour Biol，2015，36(3):2087-2095.
|
| [12] |
Li GZ, Liang HF, Liao B，et al. PX-12 inhibits the growth of hepatocelluar carcinoma by inducing S-phase arrest，ROS-dependent apoptosis and enhances 5-FU cytotoxicity[J]. Am J Transl Res，2015，7(9):1528-1540.
|
| [13] |
Lin PY, Yu CH, Wang JT，et al. Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan[J]. J Oral Pathol Med，2008，37(1):18-25.
|
| [14] |
DE Lima PO, Jorge CC, Oliveira DT，et al. Hypoxic condition and prognosis in oral squamous cell carcinoma[J]. Anticancer Res，2014，34(2):605-612.
|
| [15] |
Zhu X, Huang C, Peng B. Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue[J]. Oral Oncol，2011，47(7):609-614.
|
| [16] |
Kakolyris S, Giatromanolaki A, Koukourakis M，et al. Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer[J]. Clin Cancer Res，2001，7(10):3087-3091.
|
| [17] |
Welsh SJ, Bellamy WT, Briehl MM，et al. The redox protein thioredoxin-1（Trx-1）increases hypoxia-inducible factor 1alpha protein expression：Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis[J]. Cancer Res，2002，62(17):5089-5095.
|
| [18] |
Farina AR, Cappabianca L, DeSantis G，et al. Thioredoxin stimulates MMP-9 expression，de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells[J]. FEBS Lett，2011，585(20):3328-3336.
|