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中华口腔医学研究杂志(电子版) ›› 2016, Vol. 10 ›› Issue (05) : 356 -359. doi: 10.3877/cma.j.issn.1674-1366.2016.05.011

所属专题: 口腔医学 文献

综述

miR-221/222在肿瘤中的研究进展
周李杰1, 余东升1,()   
  1. 1. 510055 广州,中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室
  • 收稿日期:2016-01-29 出版日期:2016-10-01
  • 通信作者: 余东升
  • 基金资助:
    国家自然科学基金(81272554、81472526); 广东省科技计划(2016A020216007)

Role of miR-221/222 in tumor and their research progress in oral squamous cell carcinoma

Lijie Zhou1, Dongsheng Yu1,()   

  1. 1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2016-01-29 Published:2016-10-01
  • Corresponding author: Dongsheng Yu
  • About author:
    Corresponding author: Yu Dongsheng, Email:
引用本文:

周李杰, 余东升. miR-221/222在肿瘤中的研究进展[J]. 中华口腔医学研究杂志(电子版), 2016, 10(05): 356-359.

Lijie Zhou, Dongsheng Yu. Role of miR-221/222 in tumor and their research progress in oral squamous cell carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2016, 10(05): 356-359.

微小RNA(miR)-221和miR-222为位于X染色体上具有相同种子序列的miRNA。研究表明其在多种肿瘤中起促癌或抑癌作用,参与信号激活、细胞增殖、分化、凋亡、血管生成以及侵袭迁移等生物进程。本文就miR-221/222在肿瘤中的作用进行综述,并对其在口腔鳞状细胞癌中的研究进展做一介绍。

MiR-221 and miR-222 (miR-221/222) are microRNAs, located on the X chromosome and have the same seed sequence. Studies have shown that miR-221/222 function as oncogenes or suppressor genes in lots of advanced cancers. MiR-221/222 play an important role in tumor development, such as signal activation, cell proliferation, differentiation, apoptosis, angiogenesis, invasion, migration and other biological processes. This article reviews the role of miR-221/222 in tumor development and their research progress in oral squamous cell carcinoma.

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