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中华口腔医学研究杂志(电子版) ›› 2016, Vol. 10 ›› Issue (04) : 293 -295. doi: 10.3877/cma.j.issn.1674-1366.2016.04.013

所属专题: 口腔医学 文献

综述

抗菌十肽KSL的抗菌能力及其在口腔医学中的应用
谭易1, 古丽莎1,()   
  1. 1. 510055 广州,中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室
  • 收稿日期:2015-12-09 出版日期:2016-08-01
  • 通信作者: 古丽莎
  • 基金资助:
    国家自然科学基金(81200776); 广州市科技计划珠江新星专项(2014J2200099); 中央高校基本科研业务费中山大学青年教师培育项目(12ykpy63)

The anti-microbial activity and applications in oral medicine of KSL

Yi Tan1, Lisa Gu1,()   

  1. 1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2015-12-09 Published:2016-08-01
  • Corresponding author: Lisa Gu
  • About author:
    Corresponding author: Gu Lisa, Email:
引用本文:

谭易, 古丽莎. 抗菌十肽KSL的抗菌能力及其在口腔医学中的应用[J]. 中华口腔医学研究杂志(电子版), 2016, 10(04): 293-295.

Yi Tan, Lisa Gu. The anti-microbial activity and applications in oral medicine of KSL[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2016, 10(04): 293-295.

耐药细菌作为病原体的感染问题日益严重。抗菌肽作为一种广泛存在于生物体内的两亲性阳离子多肽,在机体免疫防御过程中有不可忽视的作用。它具有抗菌谱广、抗菌作用强且迅速、不易产生耐药性等优点。抗菌十肽KSL(KKVVFKVKFK-NH2)及其类似物是人工合成的新型小分子多肽,与天然抗菌肽相比,抗菌活性更强,组织毒性更小,具备应用于口腔抗菌材料防止继发龋的潜能。本文就KSL及其类似物抗菌性能和在口腔医学中的应用作一综述。

In recent years, owing to the abuse of antibiotics, the infection of resistant bacteria is more and more serious. Antimicrobial peptide (AMP) , a kind of common cationic amphiphilic peptides in the biological body, plays an importance role in organism immune defense. AMP has many advantages such as broad antimicrobial spectrum, highly antibacterial activities, fast working and low drug-resistance effect. Decapeptide KSL and its analogues are kinds of new synthetic antibacterial 10 peptides, which have highly antibacterial activities and less toxic compared to natural AMP, and thereby are considered to be applied in the prevention of the secondary caries. In this view, we focus on the antimicrobial characteristics and applications in oral medicine of KSL and its analogs.

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