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中华口腔医学研究杂志(电子版) ›› 2015, Vol. 09 ›› Issue (03) : 247 -251. doi: 10.3877/cma.j.issn.1674-1366.2015.03.014

所属专题: 口腔医学 文献

综述

三磷酸腺苷结合盒外排子对变异链球菌毒力因子影响的研究进展
曾荟荟1, 凌均棨1,()   
  1. 1. 510055 广州,中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室
  • 收稿日期:2015-02-09 出版日期:2015-06-01
  • 通信作者: 凌均棨

Effects of ATP-binding cassette exporters on virulence factors in Streptococcus mutans

Huihui Zeng1, Junqi Ling1,()   

  1. 1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2015-02-09 Published:2015-06-01
  • Corresponding author: Junqi Ling
  • About author:
    Corresponding author: Ling Junqi, Email:
引用本文:

曾荟荟, 凌均棨. 三磷酸腺苷结合盒外排子对变异链球菌毒力因子影响的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2015, 09(03): 247-251.

Huihui Zeng, Junqi Ling. Effects of ATP-binding cassette exporters on virulence factors in Streptococcus mutans[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2015, 09(03): 247-251.

三磷酸腺苷结合盒(ABC)转运子是膜蛋白的一部分,透过细胞膜转运各种生物分子,参与多种生理功能。在变异链球菌中,ABC外排子与基因感受态、四(五)磷酸鸟苷[(p)ppGpp]累积、细菌素分泌与免疫密切相关。本文就变异链球菌ABC外排子的结构、生理功能、作用机制和抑制剂作一综述。

ABC transporters have been proved to be integral membrane proteins that actively transported a diverse range of substrates across cell membranes. ABC transporters had varied functions, and took part in gene competence, (p) ppGpp accumulation, bacteriocin secretion and immunity in Streptococcus mutans. The structures, functions, mechanisms and inhibitors of the known ABC exporters in Streptococcus mutans were summarized.

图1 ABC外排子的三维结构[13]
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