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中华口腔医学研究杂志(电子版) ›› 2015, Vol. 09 ›› Issue (01) : 81 -84. doi: 10.3877/cma.j.issn.1674-1366.2015.01.014

所属专题: 口腔医学 文献

综述

牙源性间充质干细胞及其在牙周组织再生治疗中的应用
刘开蕾1, 刘学恒1,()   
  1. 1. 518036 北京大学深圳医院口腔科
  • 收稿日期:2014-12-28 出版日期:2015-02-01
  • 通信作者: 刘学恒

Dental-derived mesenchymal stem cells and their potential value in periodontal regeneration

Kailei Liu1, Xueheng Liu1,()   

  1. 1. Department of Stomatology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2014-12-28 Published:2015-02-01
  • Corresponding author: Xueheng Liu
  • About author:
    Corresponding author: Liu Xueheng, Email:
引用本文:

刘开蕾, 刘学恒. 牙源性间充质干细胞及其在牙周组织再生治疗中的应用[J]. 中华口腔医学研究杂志(电子版), 2015, 09(01): 81-84.

Kailei Liu, Xueheng Liu. Dental-derived mesenchymal stem cells and their potential value in periodontal regeneration[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2015, 09(01): 81-84.

牙周病是以牙周支持组织的炎症和破坏为特征的感染性疾病。牙周病基础治疗是通过去除牙菌斑以达到控制炎症的目的。但是,牙周治疗的最终目的在于修复并重建牙周组织的结构和功能,包括牙槽骨、牙周韧带、牙骨质等牙周支持组织的再生。组织工程技术的出现为牙周组织再生治疗提供了新的思路和方法,其中具有增殖分化潜能的种子细胞是目前研究热点之一。间充质干细胞属于成体干细胞,是来源于发育早期中胚层的具有高度自我更新能力和多向分化潜能的干细胞,是理想的种子细胞之一。牙源性间充质干细胞具有再生和分化潜力好、免疫原性低的特点,因而成为牙周组织再生的种子细胞。本文将针对目前研究发现的牙源性间充质干细胞的特性及在牙周组织再生中的应用作一综述。

Periodontitis is a chronic infective disease, which characterized as inflammation and destruction of the supporting tissues of the teeth. Traditional treatment strategies focus on the removal of dental plaque and the long-term control of dental plaque accumulation. However, the ultimate object of periodontal therapy is to restore the structure and function of the periodontium, which means regeneration of the supporting tissues, including alveolar bone, periodontal ligament and cementum, over a previously diseased root surface. The development of tissue engineering provides a new thought to periodontal regeneration therapy. Mesemchymal stem cells, with highly proliferation and differentiation potential, are ideal adult stem cells developed from mesoderm. With the identification of mesenchymal stem cells in oral cavity, tissue engineering using mesenchymal stem cells has become a most interesting therapeutic option. The aim of this article was to describe the main sources of dental-derived mesenchymal stem cells and their potential in regenerative therapy.

[1]
Hynes K, Menicanin D, Gronthos S,et al. Clinical utility of stem cells for periodontal regeneration[J]. Periodontol 2000,2012,59(1):203-227.
[2]
Gronthos S, Mankani M, Brahim J,et al. Postnatal human dental pulp stem cells(DPSCs)in vitro and in vivo[J]. Proc Natl Acad Sci U S A,2000,97(25):13625-13630.
[3]
Gronthos S, Brahim J, Li W,et al. Stem cell properties of human dental pulp stem cells[J]. J Dent Res,2002,81(8):531-535.
[4]
Huang GT, Yamaza T, Shea LD,et al. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model[J]. Tissue Eng Part A,2010,16(2):605-615.
[5]
毛丽霞,刘加强,赵晶蕾,等.人牙髓干细胞体外成骨向分化的实验研究[J].口腔颌面修复学杂志,2014,15(4):193-198.
[6]
Riccio M, Maraldi T, Pisciotta A,et al. Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells[J]. Tissue Eng Part A,2012,18(9-10):1006-1013.
[7]
d′Aquino R, Graziano A, Sampaolesi M,et al. Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes:a pivotal synergy leading to adult bone tissue formation[J]. Cell Death Differ,2007,14(6):1162-1171.
[8]
Sun HH, Chen B, Zhu QL,et al. Investigation of dental pulp stem cells isolated from discarded human teeth extracted due to aggressive periodontitis[J]. Biomaterials,2014,35(35):9459-9472.
[9]
Miura M, Gronthos S, Zhao M,et al. SHED:stem cells from human exfoliated deciduous teeth[J]. Proc Natl Acad Sci U S A,2003,100(10):5807-5812.
[10]
Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources:their biology and role in regenerative medicine[J]. J Dent Res,2009,88(9):792-806.
[11]
Pivoriuūnas A, Surovas A, Borutinskaite V,et al. Proteomicanalysis of stromal cells derived from the dental pulp of human exfoliated deciduous teeth[J]. Stem Cells Dev,2010,19(7):1081-1093.
[12]
王立媛,刘大勇,贾智.人脱落乳牙干细胞骨向分化相关分子Runx2的动态表达[J].中国组织工程研究,2014,18(15):2345-2350.
[13]
Sakai VT, Zhang Z, Dong Z,et al. SHED differentiate into functional odontoblasts and endothelium[J]. J Dent Res,2010,89(8):791-796.
[14]
Behnia A, Haghighat A, Talebi A,et al. Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect[J]. World J Stem Cells,2014,6(4):505-510.
[15]
Seo BM, Miura M, Gronthos S,et al. Investigation of multipotent postnatal stem cells from human periodontal ligament[J]. Lancet,2004,364(9429):149-155.
[16]
Ma Z, Li S, Song Y,et al. The biological effect of dentin noncollagenous proteins(DNCPs)on the human periodontal ligament stem cells(HPDLSCs)in vitro and in vivo[J]. Tissue Eng Part A,2008,14(12):2059-2068.
[17]
Liu Y, Zheng Y, Ding G,et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine[J]. Stem Cells,2008,26(4):1065-1073.
[18]
Ding G, Liu Y, Wang W,et al. Allogeneic periodontal ligament stem cell therapy for periodontitis in swine[J]. Stem Cells,2010,28(10):1829-1838.
[19]
Morsczeck C, Götz W, Schierholz J,et al. Isolation of precursor cells(PCs)from human dental follicle of wisdom teeth[J]. Matrix Biol,2005,24(2):155-165.
[20]
Xu LL, Liu HC, Wang DS,et al. Effects of BMP-2 and dexamethasone on osteogenic differentiation of rat dental follicle progenitor cells seeded on three-dimensional beta-TCP[J]. Biomed Mater,2009,4(6):065010.
[21]
Sonoyama W, Liu Y, Yamaza T,et al. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth:a pilot study[J]. J Endod,2008,34(2):166-171.
[22]
Ding G, Liu Y, An Y,et al. Suppression of T cell proliferation by root apical papilla stem cells in vitro[J]. Cells Tissues Organs,2010,191(5):357-364.
[23]
Guo L, Li J, Qiao X,et al. Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells[J]. PLoS One,2013,8(4):e62332.
[24]
Yagyuu T, Ikeda E, Ohgushi H,et al. Hard tissue-forming potential of stem/progenitor cells in human dental follicle and dental papilla[J]. Arch Oral Biol,2010,55(1):68-76.
[25]
Huang GT, Sonoyama W, Liu Y,et al. The hidden treasure in apical papilla:the potential role in pulp/dentin regeneration and bioroot engineering[J]. J Endod,2008,34(6):645-651.
[26]
Mitrano TI, Grob MS, Carrión F,et al. Culture and characterization of mesenchymal stem cells from human gingival tissue[J]. J Periodontol,2010,81(6):917-925.
[27]
Zhang Q, Shi S, Liu Y,et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis[J]. J Immunol,2009,183(12):7787-7798.
[28]
Tang L, Li N, Xie H,et al. Characterization of mesenchymal stem cells from human normal and hyperplastic gingiva[J]. J Cell Physiol,2011,226(3):832-842.
[29]
Wang F, Yu M, Yan X,et al. Gingival-derived mesenchymal stem cell-mediated therapeutic approach for bone tissue regeneration[J]. Stem Cells Dev,2011,20(12):2093-2102.
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