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中华口腔医学研究杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 124 -128. doi: 10.3877/cma.j.issn.1674-1366.2019.02.011

所属专题: 口腔医学 文献

综述

富血小板纤维蛋白对软组织修复与再生影响的研究进展
唐一月1, 余占海1,()   
  1. 1. 兰州大学口腔医学院(医院)口腔种植科 730000
  • 收稿日期:2019-01-22 出版日期:2019-04-01
  • 通信作者: 余占海

Research progress on the effects of platelet-rich fibrin on soft tissue repair and regeneration

Yiyue Tang1, Zhanhai Yu1,()   

  1. 1. Department of Oral Implantology, School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, China
  • Received:2019-01-22 Published:2019-04-01
  • Corresponding author: Zhanhai Yu
  • About author:
    Corresponding author: Yu Zhanhai, Email:
引用本文:

唐一月, 余占海. 富血小板纤维蛋白对软组织修复与再生影响的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2019, 13(02): 124-128.

Yiyue Tang, Zhanhai Yu. Research progress on the effects of platelet-rich fibrin on soft tissue repair and regeneration[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2019, 13(02): 124-128.

近年来随着组织工程的不断发展,关于损伤组织修复与再生的研究层出不穷,其中富血小板纤维蛋白(PRF)用于软组织修复及再生的问题成为研究热点。PRF是一种自体血来源的富含细胞生长因子的新型生物材料,被誉为第二代血小板浓缩物。本文就PRF对软组织修复及再生影响的体内研究,体外研究及临床研究作一综述。

In recent years, with the development of tissue engineering, researches on the repair and regeneration of defected tissue have emerged in an endless stream. The issue of platelet-rich fibrin (PRF) for soft tissue repair and regeneration is a hot topic. PRF is a new biological material derived from autologous blood cells and rich in cell growth factors, which is known as the second generation of platelet concentrates. This article reviews the in vivo, in vitro and clinical studies of the effects of PRF on soft tissue repair and regeneration.

[1]
Guo SA, DiPietro LA. Factors affecting wound healing[J]. J Dent Res,2010,89(3):219-229. DOI:10.1177/0022034509359125.
[2]
Nurden AT. Platelets,inflammation and tissue regeneration[J]. Thromb Haemost,2011(105 Suppl 1):S13-S33. DOI:10.1160/THS10-11-0720.
[3]
Peerbooms JC, van Laar W, Faber F,et al. Use of platelet rich plasma to treat plantar fasciitis:design of a multi centre randomized controlled trial[J]. BMC Musculoskelet Disord,2010(11):69-70. DOI:10.1186/1471-2474-11-69.
[4]
Rozman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries[J]. Acta Dermatovenerol Alp Panonica Adriat,2007,16(4):156-165.
[5]
Alsousou J, Thompson M, Hulley P,et al. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery:a review of the literature[J]. J Bone Joint Surg Br,2009,91(8):987-996. DOI:10.1302/0301-620X.91B8.22546.
[6]
Davis VL, Abukabda AB, Radio NM,et al. Platelet-rich preparations to improve healing. Part Ⅰ:workable options for every size practice[J]. J Oral Implantol,2014,40(4):500-510. DOI:10.1563/AAID-JOI-D-12-00104.
[7]
De Pascale MR, Sommese L, Casamassimi A,et al. Platelet derivatives in regenerative medicine:an update[J]. Transfus Med Rev,2015,29(1):52-61. DOI:10.1016/j.tmrv.2014.11.001.
[8]
Grambart ST. Sports medicine and platelet-rich plasma:nonsurgical therapy[J]. Clin Podiatr Med Surg,2015,32(1):99-107. DOI:10.1016/j.cpm.2014.09.006.
[9]
Choukroun J, Diss A, Simonpieri A,et al. Platelet-rich fibrin (PRF):a second generation platelet concentrate. PartⅣ:clinical effects on tissue healing[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e56-e60. DOI:10.1016/j.tripleo.2005.07.011.
[10]
Dohan DM, Choukroun J, Diss A,et al. Platelet-rich fibrin(PRF):a second generation platelet concentrate. Part Ⅰ:technological concepts and evolution[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e37-e44. DOI:10.1016/j.tripleo.2005.07.008.
[11]
Dohan DM, Choukroun J, Diss A,et al. Platelet-rich fibrin(PRF):a second generation platelet concentrate. PartⅡ:platelet-related biologic features[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e45-e50. DOI:10.1016/j.tripleo.2005.07.009.
[12]
Dohan DM, Choukroun J, Diss A,et al. Platelet-rich fibrin(PRF):a secondgeneration platelet concentrate. Part Ⅲ:leucocyte activation:a new feature for platelet concentrates?[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(3):e51-e55. DOI:10.1016/j.tripleo.2005.07.010.
[13]
Davis VL, Abukabda AB, Radio NM,et al. Platelet-rich preparations to improve healing. Part Ⅱ:platelet activation and enrichment,leukocyte inclusion,and other selection criteria[J]. J Oral Implantol,2014,40(4):511-521. DOI:10.1563/AAID-JOI-D-12-00106.
[14]
Ghasemzadeh M, Hosseini E. Intravascular leukocyte migration through platelet thrombi:directing leukocytes to sites of vascular injury[J]. Thromb Haemost,2015,113(6):1224-1235. DOI:10.1160/TH14-08-0662.
[15]
Lundquist R, Dziegiel MH, Agren MS. Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin[J]. Wound Repair Regen,2008,16(3):356-363. DOI:10.1111/j.1524-475X.2007.00344.x.
[16]
Lundquist R, Holmstrøm K, Clausen C,et al. Characteristics of an autologous leukocyte and platelet-rich fibrin patch intended for the treatment of recalcitrant wounds[J]. Wound Repair Regen,2013,21(1):66-76. DOI:10.1111/j.1524-475X.2012.00870.x.
[17]
Clipet F, Tricot S, Alno N,et al. In vitro effects of Choukroun′s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology[J]. Implant Dent,2012,21(1):51-56. DOI:10.1097/ID.0b013e31822b9cb4.
[18]
Vahabi S, Vaziri S, Torshabi M,et al. Effects of plasma rich in growth factors and platelet-rich fibrin on proliferation and viability of human gingival fibroblasts[J]. J Dent(Tehran),2015,12(7):504-512.
[19]
Roy S, Driggs J, Elgharably H,et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation[J]. Wound Repair Regen,2011,19(6):753-766. DOI:10.1111/j.1524-475X.2011.00740.x.
[20]
Kobayashi E, Flückiger L, Fujioka-Kobayashi M,et al. Comparative release of growth factors from PRP,PRF,and advanced-PRF[J]. Clin Oral Investig,2016,20(9):2353-2360. DOI:10.1007/s00784-016-1719-1.
[21]
Ng F, Boucher S, Koh S,et al. PDGF,TGF-beta,and FGF signaling is important for differentiation and growth of mesenchymal stem cells(MSCs):transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic,chondrogenic,and osteogenic lineages[J]. Blood,2008,112(2):295-307. DOI:10.1182/blood-2007-07-103697.
[22]
Roberts AB,Flanders KC,Kondaiah P,et al. Transforming growth factor β:biochemistry and roles in embryogenesis,tissue repair and remodeling,and carcinogenesis[C]. Recent Progress in Hormone Research:Proceedings of the 1987 Laurentian Hormone Conference,1988(44):157-197. DOI:10.1016/B978-0-12-571144-9.50010-7.
[23]
Bowen T, Jenkins RH, Fraser DJ. MicroRNAs,transforming growth factor beta-1,and tissue fibrosis[J]. J Pathol,2013,229(2):274-285. DOI:10.1002/path.4119.
[24]
Shamloo A, Xu H, Heilshorn S. Mechanisms of vascular endothelial growth factor-induced pathfinding by endothelial sprouts in biomaterials[J]. Tissue Eng Part A,2012,18(3-4):320-330. DOI:10.1089/ten.TEA.2011.0323.
[25]
Giannobile WV, Hernandez RA, Finkelman RD,et al. Comparative effects of plateletderived growth factor-BB and insulin-like growth factor-I,individually and in combination,on periodontal regeneration in Macaca fascicularis[J]. J Periodontal Res,1996,31(5):301-312. DOI:10.1111/j.1600-0765.1996.tb00497.x.
[26]
Bayer A, Lammel J, Rademacher F,et al. Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes[J]. Exp Dermatol,2016,25(6):460-465. DOI:10.1111/exd.12966.
[27]
Suzuki S, Morimoto N, Ikada Y. Gelatin gel as a carrier of platelet-derived growth factors[J]. J Biomater Appl,2013,28(4):595-606. DOI:10.1177/0885328212468183.
[28]
Li Q, Pan S, Dangaria SJ,et al. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation[J]. Biomed Res Int,2013(2013):638043. DOI:10.1155/2013/638043.
[29]
Horii K, Kanayama T, Miyamoto H,et al. Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters[J]. Oral Surg Oral Med Oral Pathol Oral Radiol,2014,117(4):445-453. DOI:10.1016/j.oooo.2013.12.004.
[30]
Tunali M, Özdemir H, Küçükodacı Z,et al. In vivo evaluation of titanium-prepared platelet-rich fibrin(T-PRF):a new platelet concentrate[J]. Br J Oral Maxillofac Surg,2013,51(5):438-443. DOI:10.1016/j.bjoms.2012.08.003.
[31]
Duan X, Lin Z, Lin X,et al. Study of platelet-rich fibrin combined with rat periodontal ligament stem cells in periodontal tissue regeneration[J]. J Cell Mol Med,2018,22(2):1047-1055. DOI:10.1111/jcmm.13461.
[32]
Can ME, Çakmak HB, Dereli Can G,et al. A Novel Technique for Conjunctivoplasty in a Rabbit Model:Platelet-Rich Fibrin Membrane Grafting[J]. J Ophthalmol,2016(2016):1965720. DOI:10.1155/2016/1965720.
[33]
Choi BH, Zhu SJ, Jung JH,et al. The use of autologous fibrin glue for closing sinus membrane perforations during sinus lifts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2006,101(2):150-154. DOI:10.1016/j.tripleo.2005.04.008.
[34]
Simonpieri A, Del Corso M, Sammartino G,et al. The relevance of Choukroun′s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. PartⅠ:a new grafting protocol[J]. Implant Dent,2009,18(2):102-111. DOI:10.1097/ID.0b013e318198cf00.
[35]
Simonpieri A, Del Corso M, Sammartino G,et al. The relevance of Choukroun′s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. PartⅡ:implant surgery,prosthodontics,and survival[J]. Implant Dent,2009,18(3):220-229. DOI:10.1097/ID.0b013e31819b5e3f.
[36]
Soyer T, Ayva Ş, Boybeyi Ö,et al. The effect of platelet rich fibrin on growth factor levels in urethral repair[J]. J Pediatr Surg,2013,48(12):2545-2549. DOI:10.1016/j.jpedsurg.2013.06.020.
[37]
Sun CK, Zhen YY, Leu S,et al. Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction[J]. Int J Cardiol,2014,173(3):410-423. DOI:10.1016/j.ijcard.2014.03.015.
[38]
Chen YL, Sun CK, Tsai TH,et al. Adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin scaffolds promote angiogenesis,preserve heart function,and reduce left ventricular remodeling in rat acute myocardial infarction[J]. Am J Transl Res,2015,7(5):781-803.
[39]
Jorgensen B, Karlsmark T, Vogensen H,et al. A pilot study to evaluate the safety and clinical performance of leucopatch,an autologous,additive-free,platelet-rich fibrin for the treatment of recalcitrant chronic wounds[J]. Int J Low Extrem Wounds,2011,10(4):218-223. DOI:10.1177/1534734611426755.
[40]
Löndahl M, Tarnow L, Karlsmark T,et al. Use of an autologous leucocyte and platelet-rich fibrin patch on hard-to-heal DFUs:a pilot study[J]. J Wound Care,2015,24(4):172-174,176-178. DOI:10.12968/jowc.2015.24.4.172.
[41]
Chignon-Sicard B, Georgiou CA, Fontas E,et al. Efficacy of leukocyte- and platelet-rich fibrin in wound healing:a randomized controlled clinical trial[J]. Plast Reconstr Surg,2012,130(6):819e-829e. DOI:10.1097/PRS.0b013e31826d1711.
[42]
Danielsen PL, Agren MS, Jorgensen LN. Plateletrich fibrin versus albumin in surgical wound repair:a randomized trial with paired design[J]. Ann Surg,2010,251(5):825-831. DOI:10.1097/SLA.0b013e3181d3548c.
[43]
Sclafani AP. Safety,efficacy,and utility of platelet-rich fibrin matrix in facial plastic surgery[J]. Arch Facial Plast Surg,2011,13(4):247-251. DOI:10.1001/archfacial.2011.3.
[44]
Gorlero F, Glorio M, Lorenzi P,et al. New approach in vaginal prolapse repair:mini-invasive surgery associated with application of platelet-rich fibrin[J]. Int Urogynecol J,2012,23(6):715-722. DOI:10.1007/s00192-012-1667-5.
[45]
Zumstein MA, Rumian A, Lesbats V,et al. Increased vascularization during early healing after biologic augmentation in repair of chronic rotator cuff tears using autologous leukocyte- and platelet-rich fibrin(L-PRF):a prospective randomized controlled pilot trial[J]. J Shoulder Elbow Surg,2014,23(1):3-12. DOI:10.1016/j.jse.2013.08.017.
[46]
Habesoglu M, Oysu C, Sahin S,et al. Platelet-rich fibrin plays a role on healing of acute-traumatic ear drum perforation[J]. J Craniofac Surg,2014,25(6):2056-2058. DOI:10.1097/SCS.0000000000001140.
[47]
Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin(PRF)concentrates advances patients′ own inflammatory cells,platelets and growth factors:the first introduction to the low speed centrifugation concept[J]. Eur J Trauma Emerg S,2018,44(1):87-95. DOI:10.1007/s00068-017-0767-9.
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