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中华口腔医学研究杂志(电子版) ›› 2016, Vol. 10 ›› Issue (01) : 51 -54. doi: 10.3877/cma.j.issn.1674-1366.2016.01.009

所属专题: 文献

临床研究

右美托咪定对舌癌患者围手术期炎症因子的影响
伍俏媚1, 许庆2, 吴志1,(), 翟原生2   
  1. 1. 510055 广州,中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室
    2. 510070 广州,中山大学附属第一医院东院心血管内科
  • 收稿日期:2015-09-14 出版日期:2016-02-01
  • 通信作者: 吴志

Influence of Dexmedetomidine on inflammatory factors in patients with tongue cancer during perioperative period

Qiaomei Wu1, Qing Xu2, Zhi Wu1,(), Yuansheng Zhai2   

  1. 1. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Department of Anesthesiology, Guangzhou 510055, China
    2. Department of Cardiology, The Eastern Hospital of the First Affliated Hospital, Sun Yat-sen University, Guangzhou 510070, China
  • Received:2015-09-14 Published:2016-02-01
  • Corresponding author: Zhi Wu
  • About author:
    Corresponding author: Wu Zhi, Email:
引用本文:

伍俏媚, 许庆, 吴志, 翟原生. 右美托咪定对舌癌患者围手术期炎症因子的影响[J/OL]. 中华口腔医学研究杂志(电子版), 2016, 10(01): 51-54.

Qiaomei Wu, Qing Xu, Zhi Wu, Yuansheng Zhai. Influence of Dexmedetomidine on inflammatory factors in patients with tongue cancer during perioperative period[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2016, 10(01): 51-54.

目的

探讨右美托咪定(Dex)对接受舌癌根治术患者围手术期血清炎症因子水平的影响。

方法

将行舌癌根治术的60例患者为研究对象,根据维持麻醉所用药物不同,随机分成对照组和右美托咪定组(Dex组),每组30例。采用酶联免疫吸附剂测定(ELISA)法检测麻醉诱导前30 min、切皮前、切皮后1 h、术毕、术后6 h、术后24 h患者血清中的白细胞介素1(IL-1)、IL-6、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)水平。采用SPSS 16.0统计软件对数据进行统计分析。资料以±s表示,组内比较采用配对t检验,组间比较采用t检验。P<0.05为差异有统计学意义。

结果

两组围手术期血清中炎症因子IL-1、IL-6、hs-CRP、TNF-α水平在手术中、术毕、术后6 h、术后24 h较切皮前明显升高,差异有统计学意义(P<0.01);在术毕时达到最高峰,术后逐渐下降。与对照组相比,Dex组的血浆IL-1、IL-6、hs-CRP、TNF-α水平在手术中、术毕、术后6 h、术后24 h均显著降低,差异有统计学意义(P<0.01)。

结论

右美托咪定可降低舌癌根治术患者围手术期的炎症因子水平,从而减轻舌癌根治术后的炎症反应。

Objective

The aim of the study was to evaluate the effects of Dexmedetomidine (Dex) on plasma hs-CRP, interleukin-1 (IL-1) , IL-6, tumor necrosis factor-α (TNF-α) in patients undergoing radical resection of tongue cancer.

Methods

Sixty patients with tongue cancer undergoing surgery with general anesthesia (ASAⅠ~Ⅱ) were included. They were randomly divided into Dex group and control group with each of 30. Both group of patients were rapidly induced with pro- pofol, remifentanil and cis-atracurium and followed by sevoflu- ran, remifentanil and cis-atracurium for maintenance. In addition to sevofluran, remifentanil and cis-atracurium, the Dex group also received Dexmedetomidine for maintenance. ELISA was used to examine the plasma level of hs-CRP, IL-1, IL-6, TNF-α at 30 minutes before anesthesia induction (T0) , before skin incision (T1) , 1 hour of operation (T2) , immediately postoperation (T3) , 6 h postoperation (T4) and 24 h postoperation (T5) .

Results

Plasma hs-CRP, IL-1, IL-6, TNF-α levels were obviously higher at T2, T3, T4 and T5 than at T0 and T1 in both groups (P<0.01) , with peak level at T3 and gradually decreasing postopertation. Compared with control group, plasma hs-CRP, IL-1, IL-6, TNF-α were markedly decreased in the Dex group at T2, T3, T4 and T5 (P<0.01) .

Conclusion

Dexmedetomidine could inhibit inflammation in patients undergoing radical resection of tongue cancer.

表1 两组的一般情况、手术时间和手术血流动力学指标的比较(±s
表2 两组不同时间点炎症因子水平的比较(ng/L,±s
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