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中华口腔医学研究杂志(电子版) ›› 2014, Vol. 8 ›› Issue (04) : 274 -280. doi: 10.3877/cma.j.issn.1674-1366.2014.04.002

基础研究

粪肠球菌与难治性根尖周炎相关性的Meta 分析
杜健荣1, 张晨娇1, 彭志翔1,()   
  1. 1.510055 广州,中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室
  • 收稿日期:2014-02-23 出版日期:2014-08-01
  • 通信作者: 彭志翔

Correlation between Enterococcus faecalis and refractory periapical periodontitis:A Meta Analysis

Jianrong Du1, Chenjiao Zhang1, Zhixiang Peng1,()   

  1. 1.Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2014-02-23 Published:2014-08-01
  • Corresponding author: Zhixiang Peng
引用本文:

杜健荣, 张晨娇, 彭志翔. 粪肠球菌与难治性根尖周炎相关性的Meta 分析[J/OL]. 中华口腔医学研究杂志(电子版), 2014, 8(04): 274-280.

Jianrong Du, Chenjiao Zhang, Zhixiang Peng. Correlation between Enterococcus faecalis and refractory periapical periodontitis:A Meta Analysis[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2014, 8(04): 274-280.

目的

系统评价粪肠球菌和难治性根尖周炎之间的相关性。

方法

计算机检索PubMed、ScienceDirect、EMbase、万方数据、CNKI、维普等数据库,全面收集有关难治性根尖周炎中粪肠球菌检出率的独立队列研究、病例-对照研究以及横断面研究,并追溯所获文献的参考文献,检索时限均从建库至2013 年12 月。 按纳入和排除标准筛选文献、提取资料和评价质量后,采用Stata 12.0 软件进行统计分析。

结果

最终纳入18 项研究,共728 例难治性根尖周炎病例和748 例对照病例。 Meta 分析结果显示,难治性根尖周炎中粪肠球菌的检出率明显高于对照病例,差异有统计学意义[OR=3.559,95% CI(1.696,7.470),P <0.05]。 亚组分析和敏感性分析结果与上述结果一致。

结论

粪肠球菌与难治性根尖周炎间存在较为密切的关联,但具体机制仍待进一步研究。 受纳入研究质量和数量所限,上述结论尚需今后开展更多高质量的研究加以验证和更新。

Objective

To evaluate the correlation between Enterococcus faecalis and refractory periapical periodontitis.

Methods

Databases including PubMed, ScienceDirect, EMbase, WanFang Data, CNKI and VIP were searched from inception to December, 2013, so as to identify the independent cohort studies, case-control studies and cross-sectional studies. Moreover, the references of relevant studies were retrieved. According to the inclusion and exclusion criteria, the studies were screened, the data was extracted, and the methodological quality of the included studies was assessed. Then Metaanalysis was performed by Stata 12.0 software.

Results

A total of 18 studies were included, including 728 rafractory periapical periodontitis cases and 748 controlled cases. The results of Meta-analysis showed that the refractory periapical periodontitis group was more likely to have Enterococcus faecalis infection than the control group [OR=3.559, 95% CI(1.696,7.470),P <0.05]. The same results were found in both sub-group and sensitivity analysis.

Conclusions

Enterococcus faecalis is closely related to refractory periapical periodontitis. However, detailed pathogenesis mechanism is still unknown. Due to the limited quality and quantity of the included studies, more high-quality studies are required to prove the analysis results above.

图1 文献筛选流程及结果
表1 纳入研究的基本情况
图2 粪肠球菌感染与难治性根尖周炎关系的Meta 分析(随机效应模型)
图3 粪肠球菌感染与难治性根尖周炎相关性的亚组分析
图4 粪肠球菌感染与难治性根尖周炎相关性的漏斗图分析
图5 Egger 漏斗图
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