切换至 "中华医学电子期刊资源库"

中华口腔医学研究杂志(电子版) ›› 2011, Vol. 5 ›› Issue (06) : 652 -657. doi: 10.3877/cma.j.issn.1674-1366.2011.06.016

综述

颅神经嵴细胞的迁移及特性
卢境婷1, 王旭东1, 代杰文1, 孙昊1, 沈国芳1,()   
  1. 1.200011 上海交通大学医学院附属第九人民医院口腔颌面外科,上海市口腔医学重点实验室
  • 收稿日期:2010-05-12 出版日期:2011-12-01
  • 通信作者: 沈国芳
  • 基金资助:
    国家高技术研究计划(863 计划,SQ2009AA04ZX1485930)上海市科委重点基础项目(10JC140870)上海高校创新团队发展计划

The process and characteristic of cranial neural crest cells migration

Jing-ting LU1, Xu-dong WANG1, Jie-wen DAI1, Hao SUN1, Guo-fang SHEN1,()   

  1. 1.Department of Oral and Maxillofacial Surgery, College of Stomatology, Ninth People' s Hospital, Shanghai Jiao Tong University;Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2010-05-12 Published:2011-12-01
  • Corresponding author: Guo-fang SHEN
引用本文:

卢境婷, 王旭东, 代杰文, 孙昊, 沈国芳. 颅神经嵴细胞的迁移及特性[J/OL]. 中华口腔医学研究杂志(电子版), 2011, 5(06): 652-657.

Jing-ting LU, Xu-dong WANG, Jie-wen DAI, Hao SUN, Guo-fang SHEN. The process and characteristic of cranial neural crest cells migration[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2011, 5(06): 652-657.

颅神经嵴细胞(CNCC)是动物胚胎发育过程中出现的一个暂时性、可迁移、多潜能细胞群,它对颅颌面发育具有十分重要的意义。 起源于背侧神经管的CNCC,在多种因素的调控下,于胚胎内经过长距离的、精确的迁移,最终到达其目标区域,并进一步衍生为骨、软骨、神经、结缔组织等多种组织,构成了颅颌面大部分重要的软硬组织结构。 因此,CNCC的正确迁移,是颅颌面结构正常发育的重要基础。 本文重点介绍了CNCC 的迁移过程,以及近期研究中发现的迁移过程中的细胞特性,为进一步研究颅颌面发育以及颅颌面畸形的发病机制奠定了基础。

The cranial neural crest cells (CNCC) is a temporary migratory stem cell population specific to vertebrates that originates from the dorsal part of the developing neural tube.CNCC travel a long distance in the embryo and migrate precisely into the specific branch arches.During dorsolateral migration, CNCC may interact with and receive signals from multiple sources.CNCC contribute much of the bone, cartilage, neurons, and connective tissue that make up the developing head.The correct migration of CNCC is crucial for head development.The aim of this review is to highlight the process of CNCC migration and the characteristic of CNCC during migration.

图1 神经嵴及颅神经嵴细胞的分部
图2 菱脑原节以及鳃弓的结构
1
Chai Y, Jiang X, Ito Y, et al.Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.Development,2000,127(8):1671-1679.
2
Tobin JL, Di Franco M, Eichers E, et al.Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome.Proc Natl Acad Sci U S A, 2008,105(18):6714-6719.
3
Basch ML, Bronner-Fraser M.Neural crest inducing signals.Adv Exp Med Biol, 2006,589:24-31.
4
Trainor PA.Specification of neural crest cell formation and migration in mouse embryos.Semin Cell Dev Biol, 2005,16(6):683-693.
5
Serbedzija GN, Bronner-Fraser M, Fraser SE.Vital dye analysis of cranial neural crest cell migration in the mouse embryo.Development,1992,116(2):297-307.
6
Farlie PG, Kerr R, Thomas P, et al.A paraxial exclusion zone creates patterned cranial neural crest cell outgrowth adjacent to rhombomeres 3 and 5.Dev Biol, 1999,213(1):70-84.
7
Osumi-Yamashita N, Ninomiya Y, Doi H, et al.The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos.Dev Biol, 1994,164(2):409-419.
8
Trainor PA, Tam PP.Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches.Development, 1995,121(8):2569-2582.
9
Kulesa PM, Bailey CM, Kasemeier-Kulesa JC, et al.Cranial neural crest migration: new rules for an old road.Dev Biol, 2010,344(2):543-554.
10
Teddy JM,Kulesa PM.In vivo evidence for short- and long-range cell communication in cranial neural crest cells.Development, 2004,131(24):6141-6151.
11
Berndt JD, Clay MR, Langenberg T, et al.Rho-kinase and myosin Ⅱaffect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivo.Dev Biol, 2008, 324(2):236-244.
12
Kasemeier-Kulesa JC, Teddy JM, Postovit LM, et al.Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment.Dev Dyn, 2008,237(10):2657-2666.
13
Young HM, Bergner AJ, Anderson RB, et al.Dynamics of neural crest-derived cell migration in the embryonic mouse gut.Dev Biol,2004,270(2):455-473.
14
Druckenbrod NR, Epstein ML.Behavior of enteric neural crest-derived cells varies with respect to the migratory wavefront.Dev Dyn,2007,236(1):84-92.
15
Kulesa PM, Teddy JM, Stark DA, et al.Neural crest invasion is a spatially-ordered progression into the head with higher cell proliferation at the migratory front as revealed by the photoactivatable protein, KikGR.Dev Biol, 2008,316(2):275-287.
16
Simpson MJ,Zhang DC,Mariani M,et al.Cell proliferation drives neural crest cell invasion of the intestine.Dev Biol, 2007,302(2):553-568.
17
Trainor PA, Sobieszczuk D, Wilkinson D, et al.Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.Development, 2002,129(2):433-442.
18
Köntges G, Lumsden A.Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny.Development, 1996,122(10):3229-3242.
19
Kulesa P, Ellies DL, Trainor PA.Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.Dev Dyn, 2004,229(1):14-29.
20
Kulesa PM, Lu CC, Fraser SE.Time-lapse analysis reveals a series of events by which cranial neural crest cells reroute around physical barriers.Brain Behav Evol, 2005,66(4):255-265.
21
Creuzet S, Schuler B, Couly G, et al.Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development.Proc Natl Acad Sci U S A, 2004,101(14):4843-4847.
22
Kulesa PM, Fraser SE.In ovo time-lapse analysis of chick hindbrain neural crest cell migration shows cell interactions during migration to the branchial arches.Development, 2000,127(6):1161-1172.
23
Carmona-Fontaine C, Matthews HK, Kuriyama S, et al.Contact inhibition of locomotion in vivo controls neural crest directional migration.Nature, 2008,456(7224):957-961.
24
Tickle C, Trinkaus JP.Observations on nudging cells in culture.Nature, 1976,261(5559):413.
25
Jesuthasan S.Contact inhibition/collapse and pathfinding of neural crest cells in the zebrafish trunk.Development, 1996, 122(1):381-389.
26
Golding JP, Trainor P, Krumlauf R, et al.Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.Nat Cell Biol, 2000,2(2):103-109.
27
Coles EG, Taneyhill LA, Bronner-Fraser M.A critical role for Cadherin6B in regulating avian neural crest emigration.Dev Biol, 2007,312(2):533-544.
28
Mellott DO, Burke RD.Divergent roles for Eph and ephrin in avian cranial neural crest.BMC Dev Biol, 2008,8:56.
29
Gammill LS, Gonzalez C, Bronner-Fraser M.Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation.Dev Neurobiol, 2007,67(1):47-56.
30
Schwarz Q, Vieira JM, Howard B, et al.Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells.Development, 2008,135(9):1605-1613.
31
Eberhart JK, He X, Swartz ME, et al.MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis.Nat Genet, 2008,40(3):290-298.
32
Matthews HK, Broders-Bondon F, Thiery JP, et al.Wnt11r is required for cranial neural crest migration.Dev Dyn, 2008,237(11):3404-3409.
33
Raz E, Mahabaleshwar H.Chemokine signaling in embryonic cell migration: a fisheye view.Development, 2009,136(8):1223-1229.
34
McLennan R, Kulesa PM.In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick.Dev Biol,2007,301(1):227-239.
35
Trokovic N, Trokovic R, Partanen J.Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm.Int J Dev Biol, 2005,49(7):797-805.
[1] 舒斌, 朱君佑, 祁少海. 色素上皮衍生因子在创面中的表达变化及对人真皮微血管内皮细胞的作用与机制[J/OL]. 中华损伤与修复杂志(电子版), 2021, 16(04): 301-309.
[2] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[3] 雷震, 郭正辉, 唐晨, 彭圣萌, 任艳婷, 吴宛桦, 周杰, 陈勇明, 李凌峰, 黄海, 赖义明. ASF1B通过调控P53相关信号通路促进前列腺癌迁移和增殖的研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2022, 16(03): 262-269.
[4] 赵蒙蒙, 黄洁, 余荣环, 王葆青. 过表达小GTP酶Rab32抑制非小细胞肺癌细胞侵袭性生长[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 512-518.
[5] 张燕珍, 王锡携, 文小兰. 血清巨噬细胞迁移抑制因子对活动性肺结核分诊检测的意义[J/OL]. 中华肺部疾病杂志(电子版), 2023, 16(02): 200-202.
[6] 刘晓梅, 张露, 刘旭, 梁蝶. 巨噬细胞迁移抑制因子靶向miR-127-3p对人肾癌细胞生物学行为的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2023, 13(02): 76-83.
[7] 兰伟途, 武峰, 何建昌, 兰文达, 王万宏. miRNA-199a-5p靶向CDCA7L对胶质瘤细胞迁移及侵袭的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2021, 11(05): 272-278.
[8] 徐烨. miR-491-5p靶向调控SHOC2对食管鳞癌细胞增殖、迁移及侵袭的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2019, 09(06): 333-339.
[9] 魏志鸿, 郭娟, 江哲龙, 江艺, 吕立志. miR-4458靶向结合BZW2对肝癌细胞增殖、迁移和侵袭的影响[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(01): 108-113.
[10] 汤永昌, 袁峰, 梁豪, 钟昭众, 熊志勇, 曹明波, 任昱朋, 李宇轩, 姚志成, 邓美海. HBx对HBV相关性肝癌增殖和迁移能力的影响及其机制[J/OL]. 中华肝脏外科手术学电子杂志, 2022, 11(02): 198-202.
[11] 林国桢, 代天星, 邓铭彬, 汪国营. MTCL1在肝癌中表达及其对术后复发的影响[J/OL]. 中华肝脏外科手术学电子杂志, 2021, 10(06): 622-628.
[12] 钟昭众, 熊志勇, 梁豪, 袁峰, 曹明波, 向莎, 邓美海. 生长激素受体与肝细胞癌增殖迁移及预后的关系[J/OL]. 中华肝脏外科手术学电子杂志, 2021, 10(02): 210-214.
[13] 张晓宇, 翟天宇, 黑振宇, 周迪, 王健东. 木香烃内酯对胆囊癌的抗肿瘤活性及其机制[J/OL]. 中华肝脏外科手术学电子杂志, 2020, 09(04): 389-394.
[14] 邵文哲, 孙倩男, 王道荣. Galectin-9在结直肠癌中的表达及其临床意义[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(02): 112-120.
[15] 滕振, 闫波. 转录因子HAND1基因多态性在心血管疾病中的研究进展[J/OL]. 中华诊断学电子杂志, 2023, 11(01): 5-11.
阅读次数
全文


摘要