目的

评价数字减影血管造影术（DSA）介入舌动脉超选择靶向栓塞化疗晚期舌癌的临床治疗效果。

方法

对5 例T3、T4 期舌癌患者术前行顺铂-碘油混悬乳液股动脉插管舌动脉超选择靶向栓塞化疗，其中男2 例，女3 例；年龄42 ～54 岁，平均47.3 岁；全部病例治疗前均未接受过任何抗癌药物治疗；化疗后进行疗效评价，再施行舌颈联合根治术。

结果

1 例靶向栓塞化疗10 d 后溃疡面及肿瘤完全消失， 术后病理连续切片病灶未发现癌细胞，但发现颌下有1 个淋巴结转移、见鳞癌角化珠；4 例舌癌病灶明显缩小，颈深上有1 ～2 个转移淋巴结；靶向栓塞化疗后舌体无坏死，全身及局部无明显不良反应，术后4 ～15 个月随访，未发现肿瘤复发或转移。

结论

对中晚期舌癌患者术前进行DSA 介入舌动脉超选择靶向栓塞化疗疗效好、不良反应少，值得推广。

Objective

To evaluate the clinical therapeutic efficacy of DSA-mediated superselective arteria lingualis chemoembolization targeting the advanced tongue carcinoma.

Methods

Cisplatin- lipiodol suspend galacta was applied superselectively to arteria lingualis through femoral arterial cannula at 5 preoperative patients including 2 men and 3 women， with T3，T4 stage carcinoma of tongue. The age of the five patients were 42-54， and mean age was 47.3.All cases did not received any anticancer treatment previously. The therapeutic effect was evaluated after chemotherapy， combined with radical neck dissection.

Results

In one out of the 5 cases， the ulcer and tumor disappeared completely after 10 days of chemoembolization， and no malignant cells was found in histopathological serial sections after operation， metastasis was found in submaxillary lymph nodes and SqCa horny pearl were found. In the other 4 cases， lesion diminished significantly， and metastasis were found in 1-2 upper-deep neck lymph nodes in. No necrosis was found after chemoembolization in target area， and no adverse systemic reaction occurred. No tumour recurrence or metastasis in the follow-up 4 - 15 months after operation.

Conclusions

The therapeutic efficacy of DSA-mediated superselectively arteria lingualis chemoembolization targeting advanced stage carcinoma of tongue was satisfing， and adverse reaction was little. Therefore， the treatment is worth popularization.