中华口腔医学研究杂志(电子版) ›› 2010, Vol. 4 ›› Issue (01) : 38 -42. doi: 10.3877/cma.j.issn.1674-1366.2010.01.008 × 扫一扫
临床研究
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Bi-yao XU1, Xue-cai WANG1, Jian-gen SONG1, Fa-di Wang1, Gang Xia1, Qiang-song WU1, Ao-lin WANG1, Qing-wu JIANG1, Bo CHEN1,†()
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徐碧瑶, 王学才, 宋建根, 王法弟, 夏刚, 吴强松, 王奥琳, 姜庆五, 陈波. 镍铬烤瓷冠修复患者尿镍铬水平调查研究[J/OL]. 中华口腔医学研究杂志(电子版), 2010, 4(01): 38-42.
Bi-yao XU, Xue-cai WANG, Jian-gen SONG, Fa-di Wang, Gang Xia, Qiang-song WU, Ao-lin WANG, Qing-wu JIANG, Bo CHEN. Investigation on the urine excretion of nickel and chromium related to nickel-chromium alloy dental restoration[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2010, 4(01): 38-42.
目的
探讨佩戴镍铬烤瓷冠材料对患者尿镍铬水平的影响。
方法
对浙江某县45 例烤瓷冠修复患者进行问卷调查，其中接触组（镍铬烤瓷冠）37 例、对照组（含钛烤瓷冠）8 例，对其收集尿样并测定尿中镍、铬的水平。
结果
两样本t 检验结果显示，镍铬烤瓷冠修复患者尿镍水平（平均1.47 μg/g 肌酐）与对照组（平均1.55 μg/g 肌酐）相比差别很小，接触组尿铬水平（平均2.06 μg/g 肌酐）高于对照组（平均1.17 μg/g 肌酐），但差异均没有统计学意义。线性回归分析结果显示，在控制性别、年龄、体质指数、吸烟和饮酒等因素的影响后，所有研究对象尿镍和尿铬水平均不受佩戴烤瓷冠的类型、时间和数量的影响（P ＞0.1）。
结论
本研究结果显示，目前尚不能认为镍铬烤瓷冠材料促进镍铬经尿排泄，需进一步加大样本量进行研究。
Objective
To explore the effect of wearing dental nickel-chromium alloy porcelain-fused-to-metal （PFM） crowns on the levels of urinary nickel and chromium.
Methods
Forty-five patients wearing dental PFM crowns， including 37 nickel-chrome alloy PFM crowns as the exposed group and 8 Titanium （Ti） alloy PFM crowns as the control group.Each of the participants was required to provide a urine sample for the measurement of urinary nickel and chromium and to fill a questionnaire.
Results
The independent-samples Student t tests showed that there was no significant differences between the levels of urinary nickel in the studied group（mean： 1.47 μg/g crea） and the control group （mean： 1.55 μg/g crea）.Although the level of urinary chromium in the study group （mean： 2.06 μg/g crea） was higher than the control group（mean： 1.17 μg/g crea）， there was no statistic significance.After adjusting the potential confounders， multivariable linear regression analyses also showed that the wearing of PFM crowns（type， time and number） had no effects on the level of urinary nickel and chromium （P ＞0.1）.
Conclusions
The conclusion that dental nickel-chrome alloy restoration can increase the excretion levels of urinary nickel and chromium cannot be drawn from the results of this study yet.This conclusion needs to be proved by larger samples in future studies.